دورية أكاديمية
أعرض في EDS

Interferon-gamma carrying nanoemulsion with immunomodulatory and anti-tumor activities.

التفاصيل البيبلوغرافية
العنوان: Interferon-gamma carrying nanoemulsion with immunomodulatory and anti-tumor activities.
المؤلفون: Ribeiro EB; Institute of Physics, University of Brasilia, Brasilia-DF, Brazil.; Institute of Health Science, Federal University of Mato Grosso, Sinop, MT, Brazil., de Marchi PGF; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil., Honorio-França AC; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil., França EL; Institute of Biological and Health Science, Federal University of Mato Grosso, Barra do Garças, MT, Brazil., Soler MAG; Institute of Physics, University of Brasilia, Brasilia-DF, Brazil.
المصدر: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2020 Feb; Vol. 108 (2), pp. 234-245. Date of Electronic Publication: 2019 Oct 16.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : John Wiley & Sons, c2002-
مواضيع طبية MeSH: Antineoplastic Agents/*administration & dosage , Drug Carriers/*chemistry , Emulsions/*chemistry , Immunologic Factors/*administration & dosage , Interferon-gamma/*administration & dosage, Adult ; Antineoplastic Agents/pharmacology ; Cells, Cultured ; Female ; Humans ; Immunologic Factors/pharmacology ; Interferon-gamma/pharmacology ; MCF-7 Cells ; Male ; Neoplasms/drug therapy ; Young Adult
مستخلص: The therapeutic administration of cytokines has been introduced aiming to modulate the immune response system, seeking for different approaches to face pathologies such as cancer, auto immune and infectious diseases. The objective of this study was to investigate the effects of a stable oil-in-water (O/W) nanoemulsion system carrying the cytokine Interferon gamma (IFN-γ) on the activity of phagocytes and MCF-7 human breast cancer cells. Nanoemulsions were prepared through ultra-homogenization, and they consisted of distilled water, triglycerides of capric acid/caprylic, sorbitan-oleate, polysorbate 80, and 1-butanol. IFN-γ (100 ng ml -1 ) was incorporated into two O/W nanoemulsion formulations, and these formulations were characterized in terms of their preliminary and accelerated physicochemical stability, rheological properties, droplet size, polydispersity and surface charge. We identified the most optimal IFN-γ nanoemulsion (IFN-γNE2), which remained stable under extreme temperature variations for 90 days, contained an average dose of 97 ng ml -1 of IFN-γ and exhibited a biocompatible pH and a relative stable rheological profile. Cell viability and intracellular Ca 2+ release assays conducted showed that IFN-γNE2 reduced the cell viability of MCF-7 cells without affecting the cell viability of phagocytes. Furthermore, IFN-γNE2 was able to induce cellular activity of phagocytes as evidenced by increased intracellular Ca 2+ release in these cells. Our findings on this IFN-γ nanoemulsion suggest that it can be a promising therapeutic agent for immunostimulation and cancer treatment.
(© 2019 Wiley Periodicals, Inc.)
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فهرسة مساهمة: Keywords: IFN-γ; MCF-7; blood phagocytes; cancer; cell viability; nanoemulsion
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Drug Carriers)
0 (Emulsions)
0 (Immunologic Factors)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20191007 Date Completed: 20210730 Latest Revision: 20210730
رمز التحديث: 20231215
DOI: 10.1002/jbm.a.36808
PMID: 31587469
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-4965
DOI:10.1002/jbm.a.36808