دورية أكاديمية
Design and evaluation of a multifunctional thermosensitive poloxamer-chitosan-hyaluronic acid gel for the treatment of skin burns.
| العنوان: | Design and evaluation of a multifunctional thermosensitive poloxamer-chitosan-hyaluronic acid gel for the treatment of skin burns. |
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| المؤلفون: | Soriano-Ruiz JL; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain., Calpena-Campmany AC; Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 27-31 Joan XXIII Ave., 08028 Barcelona, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 08028 Barcelona, Spain., Silva-Abreu M; Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 27-31 Joan XXIII Ave., 08028 Barcelona, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 08028 Barcelona, Spain., Halbout-Bellowa L; Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 27-31 Joan XXIII Ave., 08028 Barcelona, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 08028 Barcelona, Spain., Bozal-de Febrer N; Department of Biology, Healthcare and the Environment, Faculty of Pharmacy and Food Sciences, University of Barcelona, 27-31 Joan XXIII Ave., 08028 Barcelona, Spain., Rodríguez-Lagunas MJ; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 27-31 Joan XXIII Ave., 08028 Barcelona, Spain; Institute of Biomedicine, University of Barcelona, 08028 Barcelona, Spain., Clares-Naveros B; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Biosanitary Institute of Granada (ibs.GRANADA), Andalusian Health Service (SAS)-University of Granada, Granada, Spain. Electronic address: beatrizclares@ugr.es. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2020 Jan 01; Vol. 142, pp. 412-422. Date of Electronic Publication: 2019 Oct 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Chitosan/*chemistry , Gels/*chemistry , Hyaluronic Acid/*chemistry , Poloxamer/*chemistry, Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Biocompatible Materials/chemistry ; Burns/therapy ; Cell Line ; Chemical Phenomena ; Humans ; Hydrogels/chemistry ; Mice ; Rheology ; Spectrum Analysis ; Tissue Adhesions ; Wound Healing |
| مستخلص: | The main goal of this study was the design, development and characterization of a poloxamer/chitosan/hyaluronic based vehicle including three biological antioxidant molecules such as vitamins A, D and E aimed at improving the treatment of skin burns. The physical characterization of hydrogel, its mechanical and rheological properties as well as internal structure were investigated. Furthermore, biological characteristics such as ex vivo antimicrobial properties and in vivo wound healing were also accomplished and compared with a commercial reference. Results showed optimal physicochemical properties with biocompatible pH value of 4.6 ± 0.1 and zeta potential dependent on pH. The swelling rate was around 350% with optimal wettability, adhesion and leakage properties, as well as thermosensitive gelation processes. The microbiological assay demonstrated similar antimicrobial activity to that of commercial reference. In vivo tolerance study revealed no skin reactions. Finally, the wound healing efficacy of hydrogel in skin burn model showed dermal appendages and similar epidermis, dermis and stratum corneum to the commercial reference. These findings indicated that our hydrogel loading vitamins could be considered an outstanding candidate for further clinical studies. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antioxidants; Chitosan; Hyaluronic acid; Poloxamer 407; Skin burn; Vitamins |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Biocompatible Materials) 0 (Gels) 0 (Hydrogels) 106392-12-5 (Poloxamer) 9004-61-9 (Hyaluronic Acid) 9012-76-4 (Chitosan) |
| تواريخ الأحداث: | Date Created: 20191009 Date Completed: 20200608 Latest Revision: 20200608 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijbiomac.2019.09.113 |
| PMID: | 31593719 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2019.09.113 |