دورية أكاديمية
أعرض في EDS

Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis.

التفاصيل البيبلوغرافية
العنوان: Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis.
المؤلفون: Kortz TB; Department of Pediatrics, University of California, San Francisco, California.; Institute of Global Health Sciences, University of California, San Francisco, California., Nyirenda J; Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.; Department of Pathology, College of Medicine, University of Malawi, Blantyre, Malawi., Tembo D; Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Elfving K; Department of Infectious Diseases, Institution for Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Baltzell K; Department of Family Health Care Nursing, University of California, San Francisco, California.; Institute of Global Health Sciences, University of California, San Francisco, California., Bandawe G; Department of Biological Sciences, Malawi University of Science and Technology, Thyolo, Malawi., Rosenthal PJ; Department of Medicine, University of California, San Francisco, California., Macfarlane SB; Department of Epidemiology and Biostatistics, University of California, San Francisco, California., Mandala W; Department of Biological Sciences, Academy of Medical Sciences, Malawi University of Science and Technology, Thyolo, Malawi.; Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Nyirenda TS; Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.; Department of Pathology, College of Medicine, University of Malawi, Blantyre, Malawi.
المصدر: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2019 Dec; Vol. 101 (6), pp. 1424-1433.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE
أسماء مطبوعة: Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene
Original Publication: Baltimore.
مواضيع طبية MeSH: Malaria, Falciparum/*complications , Malaria, Falciparum/*diagnosis , Sepsis/*diagnosis , Sepsis/*parasitology, Biomarkers/blood ; Case-Control Studies ; Child, Preschool ; Cytokines/blood ; Female ; Fever/parasitology ; Humans ; Infant ; Malawi ; Male ; ROC Curve ; Retrospective Studies
مستخلص: Presently, it is difficult to accurately diagnose sepsis, a common cause of childhood death in sub-Saharan Africa, in malaria-endemic areas, given the clinical and pathophysiological overlap between malarial and non-malarial sepsis. Host biomarkers can distinguish sepsis from uncomplicated fever, but are often abnormal in malaria in the absence of sepsis. To identify biomarkers that predict sepsis in a malaria-endemic setting, we retrospectively analyzed data and sera from a case-control study of febrile Malawian children (aged 6-60 months) with and without malaria who presented to a community health center in Blantyre (January-August 2016). We characterized biomarkers for 29 children with uncomplicated malaria without sepsis, 25 without malaria or sepsis, 17 with malaria and sepsis, and 16 without malaria but with sepsis. Sepsis was defined using systemic inflammatory response criteria; biomarkers (interleukin-6 [IL-6], tumor necrosis factor receptor-1, interleukin-1 β [IL-1β], interleukin-10 [IL-10], von Willebrand factor antigen-2, intercellular adhesion molecule-1, and angiopoietin-2 [Ang-2]) were measured with multiplex magnetic bead assays. IL-6, IL-1β, and IL-10 were elevated, and Ang-2 was decreased in children with malaria compared with non-malarial fever. Children with non-malarial sepsis had greatly increased IL-1β compared with the other subgroups. IL-1β best predicted sepsis, with an area under the receiver operating characteristic (AUROC) of 0.71 (95% CI: 0.57-0.85); a combined biomarker-clinical characteristics model improved prediction (AUROC of 0.77, 95% CI: 0.67-0.85). We identified a distinct biomarker profile for non-malarial sepsis and developed a sepsis prediction model. Additional clinical and biological data are necessary to further explore sepsis pathophysiology in malaria-endemic regions.
References: PLoS One. 2011 Feb 25;6(2):e17440. (PMID: 21364762)
Springerplus. 2016 Dec 12;5(1):2091. (PMID: 28028489)
Pediatr Crit Care Med. 2017 Feb;18(2):143-150. (PMID: 27941423)
JAMA. 1991 Sep 4;266(9):1242-5. (PMID: 1870250)
Neonatology. 2012;102(1):37-44. (PMID: 22507910)
Caspian J Intern Med. 2013 Spring;4(2):627-35. (PMID: 24009950)
PLoS Negl Trop Dis. 2015 May 08;9(5):e0003750. (PMID: 25955522)
Mediators Inflamm. 2016;2016:4286576. (PMID: 27418744)
Crit Care Med. 2016 Dec;44(12):2263-2269. (PMID: 27749314)
PLoS One. 2015 Apr 09;10(4):e0122139. (PMID: 25856341)
PLoS One. 2013;8(1):e54481. (PMID: 23349902)
Front Pediatr. 2017 Dec 22;5:278. (PMID: 29312910)
Infect Immun. 2004 Oct;72(10):5630-7. (PMID: 15385460)
PLoS One. 2016 Jan 28;11(1):e0146054. (PMID: 26821179)
Clin Vaccine Immunol. 2017 Jul 5;24(7):. (PMID: 28515136)
BMC Infect Dis. 2013 Mar 05;13:117. (PMID: 23497104)
Pediatr Crit Care Med. 2016 May;17(5):400-5. (PMID: 27043996)
Trans R Soc Trop Med Hyg. 2009 Jul;103(7):679-86. (PMID: 19409589)
PLoS One. 2015 Oct 22;10(10):e0141251. (PMID: 26492036)
Crit Care. 2010;14(3):R89. (PMID: 20482750)
Pediatrics. 2003 Oct;112(4):793-9. (PMID: 14523168)
Innate Immun. 2015 Jul;21(5):546-52. (PMID: 25466232)
Acta Trop. 2007 Apr;102(1):20-8. (PMID: 17397790)
Shock. 2013 May;39(5):427-32. (PMID: 23524845)
JAMA. 2016 Feb 23;315(8):801-10. (PMID: 26903338)
PLoS One. 2010 Oct 14;5(10):e13226. (PMID: 20976241)
Indian Pediatr. 2003 Mar;40(3):204-10. (PMID: 12657751)
Front Immunol. 2017 Oct 19;8:1329. (PMID: 29097996)
Intensive Care Med. 2018 Feb;44(2):179-188. (PMID: 29256116)
Chest. 2017 Jul;152(1):22-31. (PMID: 28109962)
PLoS One. 2015 Sep 14;10(9):e0137592. (PMID: 26366571)
Crit Care. 2007;11(2):R49. (PMID: 17448250)
Crit Care Med. 1998 May;26(5):933-8. (PMID: 9590325)
Pediatrics. 2016 Aug;138(2):. (PMID: 27382134)
Clin Appl Thromb Hemost. 2015 Jul;21(5):469-74. (PMID: 24203354)
Acta Med Iran. 2015 Jul;53(7):408-11. (PMID: 26520627)
Shock. 2010 Sep;34 Suppl 1:44-7. (PMID: 20523274)
Acad Emerg Med. 2014 Aug;21(8):853-7. (PMID: 25155163)
Malar J. 2009 Dec 15;8:295. (PMID: 20003529)
Pediatr Infect Dis J. 2018 May;37(5):387-393. (PMID: 29373477)
JAMA Pediatr. 2017 Jun 1;171(6):573-592. (PMID: 28384795)
Anal Bioanal Chem. 2009 Mar;393(5):1473-80. (PMID: 19104782)
Mediators Inflamm. 2013;2013:165974. (PMID: 23853427)
Immunity. 2014 Apr 17;40(4):463-75. (PMID: 24745331)
PLoS Med. 2017 Oct 23;14(10):e1002411. (PMID: 29059253)
Pediatr Crit Care Med. 2017 Jun;18(6):513-523. (PMID: 28410274)
BMC Pediatr. 2010 Apr 16;10:22. (PMID: 20398379)
Intensive Care Med. 2012 Apr;38(4):557-74. (PMID: 22349419)
Front Pediatr. 2018 Oct 01;6:266. (PMID: 30327759)
J Emerg Med. 2012 Jul;43(1):97-106. (PMID: 22056545)
Crit Care Med. 2013 Feb;41(2):580-637. (PMID: 23353941)
PLoS One. 2011;6(11):e25626. (PMID: 22125593)
BMJ. 2003 Feb 15;326(7385):361. (PMID: 12586667)
Crit Care. 2010;14(3):R91. (PMID: 20492647)
Health Technol Assess. 2012;16(15):1-100. (PMID: 22452986)
PLoS One. 2009;4(3):e4912. (PMID: 19300530)
PLoS One. 2015 Jun 02;10(6):e0129920. (PMID: 26034987)
PLoS One. 2010 Dec 29;5(12):e15291. (PMID: 21209923)
Pediatr Crit Care Med. 2005 Jan;6(1):2-8. (PMID: 15636651)
PLoS One. 2009 Aug 13;4(8):e6621. (PMID: 19675669)
PLoS One. 2014 Sep 25;9(9):e108461. (PMID: 25255212)
Malar J. 2017 Dec 29;16(1):499. (PMID: 29284469)
N Am J Med Sci. 2013 Jun;5(6):344-52. (PMID: 23923107)
Crit Care. 2012 Oct 01;16(5):R174. (PMID: 23025259)
Clin Vaccine Immunol. 2017 Apr 5;24(4):. (PMID: 28122790)
معلومات مُعتمدة: WT087537MA United Kingdom WT_ Wellcome Trust; 08754/Z/08/Z United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Biomarkers)
0 (Cytokines)
تواريخ الأحداث: Date Created: 20191010 Date Completed: 20200324 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6896879
DOI: 10.4269/ajtmh.18-0635
PMID: 31595873
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-1645
DOI:10.4269/ajtmh.18-0635