دورية أكاديمية
أعرض في EDS

Squamous differentiation portends poor prognosis in low and intermediate-risk endometrioid endometrial cancer.

التفاصيل البيبلوغرافية
العنوان: Squamous differentiation portends poor prognosis in low and intermediate-risk endometrioid endometrial cancer.
المؤلفون: Andrade DAP; Departament of Oncology, InORP ONCOCLÍNICAS Group (Oncology Institute of Ribeirão Preto), Ribeirão Preto, São Paulo, Brazil.; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., da Silva VD; Departament of Pathology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Matsushita GM; Departament of Pathology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., de Lima MA; Epidemiology and Biostatistics Nucleus, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Vieira MA; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Andrade CEMC; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Schmidt RL; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Dos Reis R; Department of Gynecologic Oncology, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.
المصدر: PloS one [PLoS One] 2019 Oct 10; Vol. 14 (10), pp. e0220086. Date of Electronic Publication: 2019 Oct 10 (Print Publication: 2019).
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Carcinoma, Endometrioid*/diagnosis , Carcinoma, Endometrioid*/metabolism , Carcinoma, Endometrioid*/pathology , Endometrial Neoplasms*/diagnosis , Endometrial Neoplasms*/metabolism , Endometrial Neoplasms*/pathology, Aged ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Retrospective Studies ; Risk Factors
مستخلص: Background: Endometrial cancer presents well-defined risk factors: myometrial invasion, histological subtype, tumor grade, lymphovascular space invasion (LVSI). Some low and intermediate-risk endometrioid endometrial cancer patients exhibited unexpected outcomes. This study aimed to investigate other clinical-pathological factors that might influence the recurrence rates of patients diagnosed with low and intermediate-risk endometrioid endometrial cancer.
Methods: A case-control study from a cohort retrospective of 196 patients diagnosed with low and intermediate-risk endometrioid endometrial cancer at a single institution from 2009 to 2014 was conducted. Medical records were reviewed to compare clinical (race, smoking, menopause age, body mass index) and pathological (endometrioid vs endometrioid with squamous differentiation, tumor differentiation grade, tumor location, endocervical invasion, LVSI) features of patients with recurrence (case) and without recurrence (control) of disease. Three controls for each case were matched for age and staging.
Results: Twenty-one patients with recurrence were found (10.7%), of which 14 were stage IA, and 7 were stage IB. In accordance, 63 patients without recurrence were selected as controls. There were no significant differences in any clinical characteristics between cases and controls. Among pathological variables, presence of squamous differentiation (28.6% vs. 4.8%, p = 0.007), tumor differentiation grade 2 or 3 (57.1% vs. 30.2%, p = 0.037) and presence of endocervical invasion (28.6% vs. 12.7%, p = 0.103) were associated with disease recurrence on a univariate analysis. On multivariable analysis, only squamous differentiation was a significant risk factor for recurrence (p = 0.031).
Conclusion: Our data suggest that squamous differentiation may be an adverse prognostic factor in patients with low and intermediate-risk endometrioid endometrial cancer, that showed a 5.6-fold increased risk for recurrence.
Competing Interests: The authors have declared that no competing interests exist.
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تواريخ الأحداث: Date Created: 20191011 Date Completed: 20200310 Latest Revision: 20200310
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6786591
DOI: 10.1371/journal.pone.0220086
PMID: 31600211
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0220086