دورية أكاديمية
Hair cortisol concentrations in chronic central serous chorioretinopathy.
| العنوان: | Hair cortisol concentrations in chronic central serous chorioretinopathy. |
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| المؤلفون: | van Haalen FM; Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center, Leiden, the Netherlands., van Dijk EHC; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands., Savas M; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Brinks J; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands., Dekkers OM; Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center, Leiden, the Netherlands.; Department of Medicine, Division of Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Dijkman G; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands., van Rossum EFC; Department of Internal Medicine, Division of Endocrinology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Biermasz NR; Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center, Leiden, the Netherlands., Boon CJF; Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Ophthalmology, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Pereira AM; Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center, Leiden, the Netherlands. |
| المصدر: | Acta ophthalmologica [Acta Ophthalmol] 2020 Jun; Vol. 98 (4), pp. 390-395. Date of Electronic Publication: 2019 Oct 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101468102 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-3768 (Electronic) Linking ISSN: 1755375X NLM ISO Abbreviation: Acta Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Wiley-Blackwell Original Publication: Oxford, UK ; Malden, MA : Blackwell Munksgaard |
| مواضيع طبية MeSH: | Central Serous Chorioretinopathy/*metabolism , Glucocorticoids/*pharmacokinetics , Hair/*metabolism, Adult ; Aged ; Biomarkers/metabolism ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/drug therapy ; Chronic Disease ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prognosis ; Tomography, Optical Coherence |
| مستخلص: | Purpose: Central serous chorioretinopathy (CSC), a distinct form of macular degeneration, has been associated with glucocorticoid use and possibly also with an increased endogenous activity of the hypothalamic-pituitary-adrenal (HPA) axis. To estimate long-term glucocorticoid exposure, measurement of hair cortisol concentrations (HCC) has emerged. This cross-sectional study aimed to investigate HCC, as a reflection of chronic endogenous steroid exposure, in a cohort of patients with chronic CSC (cCSC). Methods: Hair cortisol concentrations (HCC) were determined in 48 patients with cCSC and 230 population-based controls (Lifelines cohort study), not using exogenous corticosteroids. Results: Increased HCC (defined as >10.49 pg/mg) were present in 2 (4%) patients with cCSC and 13 (6%) controls. Mean HCC values were not different between patients and controls, and no difference in HCC was found between patients with active cCSC disease and patients with inactive disease. No correlation between HCC and urinary free cortisol (UFC) levels in patients with cCSC was found. Conclusions: This study shows that HCC in patients with cCSC are not elevated compared to population-based controls, and no association between HCC and cCSC severity was found. This finding questions the previous suggestion that cCSC is associated with increased HPA axis activity. In line, HCC do not seem useful in monitoring cCSC disease activity. (© 2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.) |
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| معلومات مُعتمدة: | BlindenPenning; Landelijke Stichting voor Blinden en Slechtzienden; UitZicht; Rotterdamse Stichting Blindenbelangen; Stichting Blindenhulp; ZonMw VENI; Gisela Thier Fellowship of Leiden University; VIDI; Netherlands Organization of Scientific Research ZonMW |
| فهرسة مساهمة: | Keywords: central serous chorioretinopathy; cortisol; hair cortisol; hypercortisolism; hypothalamic-pituitary-adrenal axis |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20191015 Date Completed: 20210331 Latest Revision: 20210331 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/aos.14269 |
| PMID: | 31608607 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1755-3768 |
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| DOI: | 10.1111/aos.14269 |