دورية أكاديمية
أعرض في EDS

NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia.

التفاصيل البيبلوغرافية
العنوان: NAMPT levels are inversely related to nitric oxide formation and positively related to soluble fms-like tyrosine kinase-1 levels in preeclampsia.
المؤلفون: Pereira DA; Graduate Program in Genetics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Sandrim VC; Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Palei ACT; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Tanus-Santos JE; Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Belo VA; Graduate Program in Genetics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Cavalli RC; Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Luizon MR; Graduate Program in Genetics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Electronic address: luizonmr@ufmg.br.
المصدر: Pregnancy hypertension [Pregnancy Hypertens] 2019 Oct; Vol. 18, pp. 137-140. Date of Electronic Publication: 2019 Oct 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101552483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2210-7797 (Electronic) Linking ISSN: 22107789 NLM ISO Abbreviation: Pregnancy Hypertens Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amtserdam : Elsevier
مواضيع طبية MeSH: Cytokines/*blood , Nicotinamide Phosphoribosyltransferase/*blood , Pre-Eclampsia/*physiopathology , Vascular Endothelial Growth Factor Receptor-1/*blood, Adult ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Nitric Oxide/blood ; Pre-Eclampsia/blood ; Pregnancy ; Young Adult
مستخلص: NAMPT is a biomarker for endothelial dysfunction, but its relationship with nitrite (marker of NO formation) and soluble fms-like tyrosine kinase-1 (sFLT-1) has not been previously evaluated in preeclampsia. Therefore, we measured plasma NAMPT and sFLT-1 levels using enzyme immunoassays and plasma nitrite concentrations using an ozone-based chemiluminescence assay. NAMPT was positively correlated to nitrite (r = 0.217; P = 0.034) and inversely related to sFLT-1 (r = -0.340; P = 0.029) in healthy pregnant women, but inversely related to nitrite (r = -0.259; P = 0.035) and positively correlated to sFLT-1 (r = 0.326; P = 0.007) in preeclamptic patients, suggesting that NAMPT inhibits NO formation and interacts with the antiangiogenic factor sFLT-1 in preeclampsia.
(Copyright © 2019 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Nicotinamide phosphorybosil transferase (NAMPT); Nitric oxide formation; Nitrite levels; Preeclampsia; Soluble fms-like tyrosine kinase-1 (sFLT-1); Visfatin/NAMPT
المشرفين على المادة: 0 (Biomarkers)
0 (Cytokines)
31C4KY9ESH (Nitric Oxide)
EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
تواريخ الأحداث: Date Created: 20191015 Date Completed: 20200514 Latest Revision: 20200514
رمز التحديث: 20231215
DOI: 10.1016/j.preghy.2019.09.022
PMID: 31610400
قاعدة البيانات: MEDLINE
الوصف
تدمد:2210-7797
DOI:10.1016/j.preghy.2019.09.022