دورية أكاديمية
أعرض في EDS

Signal Alteration of Substantia Nigra on 3.0T Susceptibility-weighted Imaging in Parkinson's Disease and Vascular Parkinsonism.

التفاصيل البيبلوغرافية
العنوان: Signal Alteration of Substantia Nigra on 3.0T Susceptibility-weighted Imaging in Parkinson's Disease and Vascular Parkinsonism.
المؤلفون: Zhao XJ; Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Niu XY; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., You HY; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Zhou M; Neurocritical Care Unit, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Ji XB; Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Liu Y; Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Wu L; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. wulei78@126.com., Ding XL; Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. merryding@163.com.
المصدر: Current medical science [Curr Med Sci] 2019 Oct; Vol. 39 (5), pp. 831-835. Date of Electronic Publication: 2019 Oct 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Huazhong University of Science and Technology Country of Publication: China NLM ID: 101729993 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2523-899X (Electronic) Linking ISSN: 2523899X NLM ISO Abbreviation: Curr Med Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Wuhan : Huazhong University of Science and Technology, [2018]-
مواضيع طبية MeSH: Dementia, Multi-Infarct/*diagnostic imaging , Magnetic Resonance Imaging/*statistics & numerical data , Parkinson Disease/*diagnostic imaging , Substantia Nigra/*diagnostic imaging, Aged ; Aged, 80 and over ; Biomarkers/analysis ; Case-Control Studies ; Dementia, Multi-Infarct/pathology ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/pathology ; Sensitivity and Specificity ; Substantia Nigra/blood supply ; Substantia Nigra/pathology
مستخلص: Recent researches have found that 7 Tesla SWI can detect the alteration of substantia nigra hyperintensity in Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). The aim of this study was to investigate whether 3 Tesla SWI (3T SWI) can visualize anatomical alterations occurring in a hyperintense structure of the substantia nigra in PD and vascular parkinsonism (VP), and whether the evaluation of abnormal signal can be used as a factor in the differential diagnosis of PD and VP. Using 3 Tesla MRI, we evaluated 38 healthy subjects, 33 patients with PD and 34 patients with VP. Two blinded readers independently assessed the images. We found that the dorsolateral nigral hyperintensity was absent in 31 of 33 patients with PD and 15 of 34 patients with VP. The dorsolateral nigral hyperintensity was present in 19 of 34 patients with VP and 35 of 38 healthy controls. Group comparisons of absence of dorsolateral nigral hyperintensity revealed significant differences between the patients with PD and those with VP (P<0.001). The sensitivity of SWI for PD was 93.9% and the specificity was 92.1%. Visual assessment of dorsolateral nigral hyperintensity on high-field SWI scans may serve as a new simple diagnostic imaging marker for PD. And our study results indicate that 3T SWI can be used as a tool to identify PD and VP.
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فهرسة مساهمة: Keywords: Parkinson’s disease; magnetic resonance imaging; substantia nigra; susceptibility-weighted imaging; vascular parkinsonism
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20191016 Date Completed: 20200219 Latest Revision: 20210720
رمز التحديث: 20231215
DOI: 10.1007/s11596-019-2113-4
PMID: 31612404
قاعدة البيانات: MEDLINE
الوصف
تدمد:2523-899X
DOI:10.1007/s11596-019-2113-4