دورية أكاديمية
Neoadjuvant cisplatin and paclitaxel modulate tumor-infiltrating T cells in patients with cervical cancer.
| العنوان: | Neoadjuvant cisplatin and paclitaxel modulate tumor-infiltrating T cells in patients with cervical cancer. |
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| المؤلفون: | Heeren AM; Department of Obstetrics and Gynecology, Center Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center Amsterdam, Amsterdam, The Netherlands., van Luijk IF; Department of Obstetrics and Gynecology, Center Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Lakeman J; Department of Obstetrics and Gynecology, Center Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Pocorni N; Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, VU University Medical Center Amsterdam, Amsterdam, The Netherlands., Kole J; Laboratory for Physiology, Institute for Cardiovascular Research, Amsterdam UMC, VU University Medical Center Amsterdam, Amsterdam, The Netherlands., de Menezes RX; Department of Epidemiology and Biostatistics, Amsterdam UMC, VU University Medical Center Amsterdam, Amsterdam, The Netherlands., Kenter GG; Department of Obstetrics and Gynecology, Center Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands., Bosse T; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., de Kroon CD; Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands., Jordanova ES; Department of Obstetrics and Gynecology, Center Gynecological Oncology Amsterdam (CGOA), Amsterdam UMC, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. e.jordanova@vumc.nl. |
| المصدر: | Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2019 Nov; Vol. 68 (11), pp. 1759-1767. Date of Electronic Publication: 2019 Oct 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York, NY : Springer International, c1982- |
| مواضيع طبية MeSH: | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Lymphocytes, Tumor-Infiltrating/*immunology , Neoadjuvant Therapy/*methods , T-Lymphocytes, Regulatory/*immunology , Uterine Cervical Neoplasms/*drug therapy , Uterine Cervical Neoplasms/*immunology, Adult ; Chemotherapy, Adjuvant ; Cisplatin/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Paclitaxel/administration & dosage ; Pilot Projects ; Prognosis ; Retrospective Studies ; Uterine Cervical Neoplasms/pathology ; Young Adult |
| مستخلص: | Resistance to chemotherapy is widely recognized as one of the major factors limiting therapeutic efficacy and influences clinical outcomes in patients with cancer. Many studies on various tumor types have focused on combining standard-of-care chemotherapy with immunotherapy. However, for cervical cancer, the role of neoadjuvant chemotherapy (NACT) on the local immune microenvironment is largely unexplored. We performed a pilot study on 13 primary cervical tumor samples, before and after NACT, to phenotype and enumerate tumor-infiltrating T-cell subpopulations using multiplex immunohistochemistry (CD3, CD8, FoxP3, Ki67, and Tbet) and automated co-expression analysis software. A significant decrease in proliferating (Ki67 + ) CD3 + CD8 - T cells and FoxP3 + (CD3 + CD8 - ) regulatory T cells was observed in the tumor stroma after cisplatin and paclitaxel treatment, with increased rates of cytotoxic CD8 + T cells, including activated and CD8 + Tbet + T cells. No effect was observed on the number of tumor-infiltrating T cells in the cervical tumor microenvironment after treatment with cisplatin only. Therefore, we conclude that patients treated with cisplatin and paclitaxel had more tumor-infiltrating T-cell modulation than patients treated with cisplatin monotherapy. These findings enhance our understanding of the immune-modulating effect of chemotherapy and warrant future combination of the standard-of-care therapy with immunotherapy to improve clinical outcome in patients with cervical cancer. |
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| معلومات مُعتمدة: | VU2013-6015 KWF Kankerbestrijding |
| فهرسة مساهمة: | Keywords: Cervical cancer; Cisplatin; Neoadjuvant chemotherapy; Paclitaxel; T cells; Tumor microenvironment |
| المشرفين على المادة: | P88XT4IS4D (Paclitaxel) Q20Q21Q62J (Cisplatin) |
| تواريخ الأحداث: | Date Created: 20191017 Date Completed: 20191127 Latest Revision: 20191204 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6851216 |
| DOI: | 10.1007/s00262-019-02412-x |
| PMID: | 31616965 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-0851 |
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| DOI: | 10.1007/s00262-019-02412-x |