دورية أكاديمية
Comparative Preclinical Pharmacokinetics and Bioavailability of Antidepressant GSB-106 Tablet Form.
| العنوان: | Comparative Preclinical Pharmacokinetics and Bioavailability of Antidepressant GSB-106 Tablet Form. |
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| المؤلفون: | Kolyvanov GB; Laboratory of Pharmacokinetics, Moscow, Russia. litbiopharm@yandex.ru., Zherdev VP; Laboratory of Pharmacokinetics, Moscow, Russia., Gribakina OG; Laboratory of Pharmacokinetics, Moscow, Russia., Bochkov PO; Laboratory of Pharmacokinetics, Moscow, Russia., Shevchenko RV; Laboratory of Pharmacokinetics, Moscow, Russia., Litvin AA; Laboratory of Pharmacokinetics, Moscow, Russia., Blynskaya EV; Laboratory of Finished Dosage Forms, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia., Bueva VV; Laboratory of Finished Dosage Forms, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. |
| المصدر: | Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Sep; Vol. 167 (5), pp. 637-640. Date of Electronic Publication: 2019 Oct 17. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: New York, Consultants Bureau. |
| مواضيع طبية MeSH: | Antidepressive Agents/*pharmacokinetics , Dipeptides/*pharmacokinetics, Administration, Oral ; Animals ; Antidepressive Agents/blood ; Area Under Curve ; Biological Availability ; Dipeptides/blood ; Drug Evaluation, Preclinical ; Male ; Rabbits ; Tablets |
| مستخلص: | Pharmacokinetics and relative bioavailability of antidepressant GSB-106 (hexamethylendiamide bis-(N-monosuccinyl-L-seryl-L-lysine) were determined in rabbits after single oral administration of the pharmaceutical substance and tablet mass. GSB-106 concentrations in the blood plasma were determined by HPLC-mass spectrometry. Relative bioavailability of GSB-106 tablet form was 160.79±24.33%. |
| فهرسة مساهمة: | Keywords: GSB-106; HPLC-MS; antidepressant; preclinical pharmacokinetics |
| المشرفين على المادة: | 0 (Antidepressive Agents) 0 (Dipeptides) 0 (Tablets) 0 (bis-(N-monosuccinyl-l-seryl-l-lysine)hexamethylenediamide) |
| تواريخ الأحداث: | Date Created: 20191019 Date Completed: 20200403 Latest Revision: 20200403 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10517-019-04587-w |
| PMID: | 31625065 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-8221 |
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| DOI: | 10.1007/s10517-019-04587-w |