دورية أكاديمية
Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.
العنوان: | Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. |
---|---|
المؤلفون: | Walsh CM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Hill RZ; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Schwendinger-Schreck J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Deguine J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Brock EC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Kucirek N; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Rifi Z; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Wei J; Vision Science Program, School of Optometry, University of California, Berkeley, Berkeley, United States., Gronert K; Vision Science Program, School of Optometry, University of California, Berkeley, Berkeley, United States., Brem RB; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.; Buck Institute for Research on Aging, Novato, United States., Barton GM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Bautista DM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United States. |
المصدر: | ELife [Elife] 2019 Oct 21; Vol. 8. Date of Electronic Publication: 2019 Oct 21. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
مواضيع طبية MeSH: | Dermatitis, Atopic/*immunology , Neutrophils/*immunology , Pruritus/*immunology , Receptors, CXCR3/*immunology , Skin/*immunology, Animals ; Calcitriol/administration & dosage ; Calcitriol/analogs & derivatives ; Cell Line ; Chemokine CXCL10/genetics ; Chemokine CXCL10/immunology ; Chemokine CXCL10/metabolism ; Cytokines/genetics ; Cytokines/immunology ; Cytokines/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/genetics ; Disease Models, Animal ; Gene Expression Profiling/methods ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Keratinocytes/immunology ; Keratinocytes/metabolism ; Mice, Inbred C57BL ; Neutrophils/metabolism ; Pruritus/chemically induced ; Pruritus/genetics ; Receptors, CXCR3/genetics ; Receptors, CXCR3/metabolism ; Sensory Receptor Cells/immunology ; Sensory Receptor Cells/metabolism ; Skin/innervation ; Skin/metabolism |
مستخلص: | Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the development of itch and the acute-to-chronic itch transition remain unknown. Here, we show that skin-infiltrating neutrophils are key initiators of itch in atopic dermatitis, the most prevalent chronic itch disorder. Neutrophil depletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis. Neutrophils were also required for several key hallmarks of chronic itch, including skin hyperinnervation, enhanced expression of itch signaling molecules, and upregulation of inflammatory cytokines, activity-induced genes, and markers of neuropathic itch. Finally, we demonstrate that neutrophils are required for induction of CXCL10, a ligand of the CXCR3 receptor that promotes itch via activation of sensory neurons, and we find that that CXCR3 antagonism attenuates chronic itch. Competing Interests: CW, RH, JS, JD, EB, NK, ZR, JW, KG, RB, DB, GB No competing interests declared (© 2019, Walsh et al.) |
التعليقات: | Comment in: Elife. 2019 Nov 29;8:. (PMID: 31782733) |
References: | Neuroscience. 2000;101(3):745-57. (PMID: 11113323) Arthritis Rheum. 2012 Jun;64(6):1730-9. (PMID: 22147649) Eur J Pain. 2013 May;17(5):654-63. (PMID: 23132735) JCI Insight. 2019 Jun 11;5:null. (PMID: 31184997) Dermatol Ther (Heidelb). 2016 Dec;6(4):509-517. (PMID: 27730494) Trends Immunol. 2017 Jan;38(1):5-19. (PMID: 27793571) J Invest Dermatol. 2010 Dec;130(12):2736-42. (PMID: 20703245) Cell. 2006 Mar 24;124(6):1269-82. (PMID: 16564016) J Allergy Clin Immunol. 2014 Feb;133(2):448-60. (PMID: 24373353) Immunity. 2012 Oct 19;37(4):747-58. (PMID: 23063331) J Clin Med. 2015 Apr 29;4(5):858-73. (PMID: 26239452) Brain. 2014 Feb;137(Pt 2):313-22. (PMID: 23794605) Nat Neurosci. 2018 May;21(5):707-716. (PMID: 29556030) Nat Commun. 2018 Jan 2;9(1):37. (PMID: 29295977) J Invest Dermatol. 2018 Jun;138(6):1311-1317. (PMID: 29317264) J Allergy Clin Immunol. 2013 Aug;132(2):361-70. (PMID: 23777851) J Invest Dermatol. 2009 Feb;129(2):498-502. (PMID: 18650845) J Exp Med. 2009 May 11;206(5):1135-47. (PMID: 19414552) J Invest Dermatol. 2015 Aug;135(8):2049-2057. (PMID: 25848979) Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7572-E7579. (PMID: 27821781) Genome Biol. 2009;10(3):R25. (PMID: 19261174) J Leukoc Biol. 2002 Apr;71(4):669-76. (PMID: 11927654) J Allergy Clin Immunol. 2016 Feb;137(2):482-91. (PMID: 26299987) J Invest Dermatol. 2019 May;139(5):984-990.e1. (PMID: 31010529) J Am Acad Dermatol. 2005 Dec;53(6):1027-37. (PMID: 16310064) Life Sci. 2018 Jan 15;193:282-291. (PMID: 28966134) Sci Transl Med. 2011 Feb 9;3(69):69ra12. (PMID: 21307302) J Allergy Clin Immunol. 1999 Apr;103(4):663-70. (PMID: 10200017) Acta Derm Venereol. 2011 Oct;91(6):674-9. (PMID: 21879245) Neuron. 2015 Jul 1;87(1):124-38. (PMID: 26074006) Allergy Asthma Immunol Res. 2011 Apr;3(2):67-73. (PMID: 21461244) Semin Cutan Med Surg. 2011 Jun;30(2):87-92. (PMID: 21767768) Nat Med. 2015 Aug;21(8):927-31. (PMID: 26193341) Br J Pharmacol. 2003 Jul;139(6):1135-45. (PMID: 12871832) Exp Dermatol. 2002 Feb;11(1):12-24. (PMID: 11952824) J Invest Dermatol. 2000 May;114(5):976-83. (PMID: 10771480) Cell Tissue Res. 2018 Mar;371(3):531-539. (PMID: 29383445) Cell Rep. 2016 Nov 8;17(7):1719-1727. (PMID: 27829143) Pain. 2015 Sep;156(9):1737-46. (PMID: 25932692) J Invest Dermatol. 2012 Jan;132(1):246-9. (PMID: 21850022) Nat Rev Neurosci. 2006 Jul;7(7):535-47. (PMID: 16791143) Cell Rep. 2019 Mar 26;26(13):3561-3573.e4. (PMID: 30917312) Clin Exp Allergy. 2017 Dec;47(12):1648-1660. (PMID: 28977706) Clin Exp Dermatol. 2013 Aug;38(6):665-8. (PMID: 23745989) Sci Rep. 2018 Apr 16;8(1):5988. (PMID: 29662233) J Invest Dermatol. 2017 Dec;137(12):2523-2531. (PMID: 28774591) J Allergy Clin Immunol. 2017 Feb;139(2):562-571. (PMID: 27702671) J Dermatol Sci. 2010 Jun;58(3):193-7. (PMID: 20417061) Ann N Y Acad Sci. 2006 Jun;1069:155-67. (PMID: 16855143) Annu Rev Cell Dev Biol. 2018 Oct 6;34:523-544. (PMID: 30089221) Nat Protoc. 2013 Sep;8(9):1765-86. (PMID: 23975260) Cell. 2018 May 17;173(5):1083-1097.e22. (PMID: 29754819) Eur J Immunol. 2007 Sep;37(9):2627-34. (PMID: 17668902) J Physiol Pharmacol. 2017 Jun;68(3):385-395. (PMID: 28820395) J Neurophysiol. 2017 Jul 1;118(1):619-624. (PMID: 28446581) FEBS J. 2018 Sep;285(17):3138-3151. (PMID: 29637705) J Allergy Clin Immunol. 2017 Apr;139(4S):S65-S76. (PMID: 28390479) J Immunol. 2016 Feb 1;196(3):1227-38. (PMID: 26718341) Nat Genet. 2007 May;39(5):650-4. (PMID: 17417636) J Allergy Clin Immunol. 2009 Dec;124(6):1235-1244.e58. (PMID: 20004782) Cell Host Microbe. 2014 Feb 12;15(2):203-13. (PMID: 24528866) Clin Rev Allergy Immunol. 2016 Dec;51(3):263-292. (PMID: 25931325) Lancet. 2010 Sep 25;376(9746):1094-108. (PMID: 20870100) J Immunol. 2002 Jan 15;168(2):846-52. (PMID: 11777981) J Allergy Clin Immunol. 2012 Dec;130(6):1344-54. (PMID: 22951056) Mol Immunol. 2015 Jan;63(1):38-44. (PMID: 24666768) N Engl J Med. 2016 Dec 15;375(24):2335-2348. (PMID: 27690741) Pain. 2008 Oct 31;139(3):681-7. (PMID: 18789837) J Dermatol. 2014 Mar;41(3):205-12. (PMID: 24628070) Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6808-17. (PMID: 26598697) Neurosci Bull. 2018 Feb;34(1):54-63. (PMID: 28401489) Neurosci Bull. 2012 Apr;28(2):145-54. (PMID: 22466125) Immunity. 2019 May 21;50(5):1163-1171.e5. (PMID: 31027996) Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1536-41. (PMID: 19188585) J Allergy Clin Immunol. 1987 Jul;80(1):87-93. (PMID: 3598032) J Invest Dermatol. 1976 Sep;67(3):305-12. (PMID: 965785) Mol Cell Biol. 2004 Mar;24(6):2584-92. (PMID: 14993294) Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9099-104. (PMID: 19458046) Neurosci Biobehav Rev. 2009 Jun;33(6):784-92. (PMID: 19167424) PLoS Biol. 2009 May 19;7(5):e1000067. (PMID: 19557146) Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286) J Dermatol Sci. 2007 Jun;46(3):199-210. (PMID: 17350228) Sci Transl Med. 2013 Jan 30;5(170):170ra16. (PMID: 23363980) Elife. 2018 Mar 21;7:. (PMID: 29561262) J Allergy Clin Immunol. 2018 May;141(5):1677-1689.e8. (PMID: 29427643) Nature. 2012 Oct 4;490(7418):107-11. (PMID: 22902502) Eur J Immunol. 2007 Feb;37(2):338-50. (PMID: 17274000) Nat Med. 2018 May;24(4):417-426. (PMID: 29505031) PLoS One. 2013;8(1):e55255. (PMID: 23372844) Free Radic Biol Med. 2011 Sep 1;51(5):951-66. (PMID: 21277369) J Invest Dermatol. 2015 Apr;135(4):984-991. (PMID: 25521458) Acta Derm Venereol. 2012 Sep;92(5):521-8. (PMID: 22565412) Cell. 2017 Sep 21;171(1):217-228.e13. (PMID: 28890086) Nat Neurosci. 2011 May;14(5):595-602. (PMID: 21460831) J Dermatol Sci. 2009 Jul;55(1):40-6. (PMID: 19443185) Nat Neurosci. 2015 Jan;18(1):145-53. (PMID: 25420068) Int J Cosmet Sci. 2004 Feb;26(1):1-7. (PMID: 18494919) J Allergy Clin Immunol. 2012 Dec;130(6):1335-43.e5. (PMID: 22920495) Nat Immunol. 2017 Jan;18(1):64-73. (PMID: 27869817) J Immunol. 2014 May 1;192(9):4361-9. (PMID: 24663678) Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11736-41. (PMID: 16880407) Cell Physiol Biochem. 2015;35(3):1023-33. (PMID: 25661672) Methods Mol Biol. 2017;1559:91-106. (PMID: 28063040) Biol Pharm Bull. 2013;36(8):1241-7. (PMID: 23902967) J Allergy Clin Immunol. 2010 Jun;125(6):1403-1407.e4. (PMID: 20466416) Sci Transl Med. 2019 Jul 10;11(500):null. (PMID: 31292265) J Allergy Clin Immunol. 1989 Feb;83(2 Pt 1):450-5. (PMID: 2537352) J Allergy Clin Immunol. 2003 Dec;112(6 Suppl):S118-27. (PMID: 14657842) Cell Death Dis. 2017 Apr 6;8(4):e2735. (PMID: 28383552) J Invest Dermatol. 2008 Nov;128(11):2625-30. (PMID: 18432274) J Allergy Clin Immunol. 2014 Dec;134(6):1293-1300. (PMID: 25482871) Neuron. 2018 May 2;98(3):482-494. (PMID: 29723501) Nat Genet. 2006 Apr;38(4):441-6. (PMID: 16550169) J Leukoc Biol. 2008 Jan;83(1):122-30. (PMID: 17913976) Curr Opin Immunol. 2017 Oct;48:68-73. (PMID: 28869867) Yale J Biol Med. 2017 Sep 25;90(3):389-402. (PMID: 28955179) Curr Allergy Asthma Rep. 2008 Jul;8(4):306-11. (PMID: 18606082) |
معلومات مُعتمدة: | T32 NS007224 United States NS NINDS NIH HHS; NS07224 United States NS NINDS NIH HHS; R56 NS098097 United States NS NINDS NIH HHS; R01 EY026082 United States EY NEI NIH HHS; R01 AI105184 United States AI NIAID NIH HHS; R01 AI104914 United States AI NIAID NIH HHS; AR059385 United States AR NIAMS NIH HHS; S10 OD018174 United States OD NIH HHS; NS098097 United States NS NINDS NIH HHS; AI105184 International National Institute of Allergy and Infectious Diseases; EY026082 United States EY NEI NIH HHS; LT-000081/2013-L International Human Frontier Science Program; AI063302 International National Institute of Allergy and Infectious Diseases; R01 AI072429 United States AI NIAID NIH HHS; R01 AR059385 United States AR NIAMS NIH HHS; AI104914 International National Institute of Allergy and Infectious Diseases; P01 AI063302 United States AI NIAID NIH HHS; AI072429 International National Institute of Allergy and Infectious Diseases |
فهرسة مساهمة: | Keywords: atopic dermatitis; chronic itch; immunology; inflammation; itch; mouse; neuroimmune; neuroscience; neutrophils; somatosensory |
سلسلة جزيئية: | GEO GSE132173; GSE132174 |
المشرفين على المادة: | 0 (Chemokine CXCL10) 0 (Cytokines) 0 (Receptors, CXCR3) 143NQ3779B (calcipotriene) FXC9231JVH (Calcitriol) |
تواريخ الأحداث: | Date Created: 20191022 Date Completed: 20200504 Latest Revision: 20200505 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC6884397 |
DOI: | 10.7554/eLife.48448 |
PMID: | 31631836 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2050-084X |
---|---|
DOI: | 10.7554/eLife.48448 |