دورية أكاديمية
أعرض في EDS

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.

التفاصيل البيبلوغرافية
العنوان: Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.
المؤلفون: Walsh CM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Hill RZ; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Schwendinger-Schreck J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Deguine J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Brock EC; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Kucirek N; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Rifi Z; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Wei J; Vision Science Program, School of Optometry, University of California, Berkeley, Berkeley, United States., Gronert K; Vision Science Program, School of Optometry, University of California, Berkeley, Berkeley, United States., Brem RB; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, United States.; Buck Institute for Research on Aging, Novato, United States., Barton GM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States., Bautista DM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, United States.
المصدر: ELife [Elife] 2019 Oct 21; Vol. 8. Date of Electronic Publication: 2019 Oct 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Dermatitis, Atopic/*immunology , Neutrophils/*immunology , Pruritus/*immunology , Receptors, CXCR3/*immunology , Skin/*immunology, Animals ; Calcitriol/administration & dosage ; Calcitriol/analogs & derivatives ; Cell Line ; Chemokine CXCL10/genetics ; Chemokine CXCL10/immunology ; Chemokine CXCL10/metabolism ; Cytokines/genetics ; Cytokines/immunology ; Cytokines/metabolism ; Dermatitis, Atopic/chemically induced ; Dermatitis, Atopic/genetics ; Disease Models, Animal ; Gene Expression Profiling/methods ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Humans ; Keratinocytes/immunology ; Keratinocytes/metabolism ; Mice, Inbred C57BL ; Neutrophils/metabolism ; Pruritus/chemically induced ; Pruritus/genetics ; Receptors, CXCR3/genetics ; Receptors, CXCR3/metabolism ; Sensory Receptor Cells/immunology ; Sensory Receptor Cells/metabolism ; Skin/innervation ; Skin/metabolism
مستخلص: Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the development of itch and the acute-to-chronic itch transition remain unknown. Here, we show that skin-infiltrating neutrophils are key initiators of itch in atopic dermatitis, the most prevalent chronic itch disorder. Neutrophil depletion significantly attenuated itch-evoked scratching in a mouse model of atopic dermatitis. Neutrophils were also required for several key hallmarks of chronic itch, including skin hyperinnervation, enhanced expression of itch signaling molecules, and upregulation of inflammatory cytokines, activity-induced genes, and markers of neuropathic itch. Finally, we demonstrate that neutrophils are required for induction of CXCL10, a ligand of the CXCR3 receptor that promotes itch via activation of sensory neurons, and we find that that CXCR3 antagonism attenuates chronic itch.
Competing Interests: CW, RH, JS, JD, EB, NK, ZR, JW, KG, RB, DB, GB No competing interests declared
(© 2019, Walsh et al.)
التعليقات: Comment in: Elife. 2019 Nov 29;8:. (PMID: 31782733)
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معلومات مُعتمدة: T32 NS007224 United States NS NINDS NIH HHS; NS07224 United States NS NINDS NIH HHS; R56 NS098097 United States NS NINDS NIH HHS; R01 EY026082 United States EY NEI NIH HHS; R01 AI105184 United States AI NIAID NIH HHS; R01 AI104914 United States AI NIAID NIH HHS; AR059385 United States AR NIAMS NIH HHS; S10 OD018174 United States OD NIH HHS; NS098097 United States NS NINDS NIH HHS; AI105184 International National Institute of Allergy and Infectious Diseases; EY026082 United States EY NEI NIH HHS; LT-000081/2013-L International Human Frontier Science Program; AI063302 International National Institute of Allergy and Infectious Diseases; R01 AI072429 United States AI NIAID NIH HHS; R01 AR059385 United States AR NIAMS NIH HHS; AI104914 International National Institute of Allergy and Infectious Diseases; P01 AI063302 United States AI NIAID NIH HHS; AI072429 International National Institute of Allergy and Infectious Diseases
فهرسة مساهمة: Keywords: atopic dermatitis; chronic itch; immunology; inflammation; itch; mouse; neuroimmune; neuroscience; neutrophils; somatosensory
سلسلة جزيئية: GEO GSE132173; GSE132174
المشرفين على المادة: 0 (Chemokine CXCL10)
0 (Cytokines)
0 (Receptors, CXCR3)
143NQ3779B (calcipotriene)
FXC9231JVH (Calcitriol)
تواريخ الأحداث: Date Created: 20191022 Date Completed: 20200504 Latest Revision: 20200505
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6884397
DOI: 10.7554/eLife.48448
PMID: 31631836
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.48448