دورية أكاديمية
The Role of Complement in Organ Transplantation.
| العنوان: | The Role of Complement in Organ Transplantation. |
|---|---|
| المؤلفون: | Grafals M; Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States., Thurman JM; Department of Medicine, University of Colorado School of Medicine, Aurora, CO, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2019 Oct 04; Vol. 10, pp. 2380. Date of Electronic Publication: 2019 Oct 04 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Organ Transplantation*, Complement System Proteins/*physiology, Adaptive Immunity ; Complement Activation ; Graft Rejection/immunology ; Humans ; Receptors, Complement/physiology ; Reperfusion Injury/immunology ; Transplantation, Heterologous |
| مستخلص: | The current immunosuppressive protocols used in transplant recipients have improved short-term outcomes, but long-term allograft failure remains an important clinical problem. Greater understanding of the immunologic mechanisms that cause allograft failure are needed, as well as new treatment strategies for protecting transplanted organs. The complement cascade is an important part of the innate immune system. Studies have shown that complement activation contributes to allograft injury in several clinical settings, including ischemia/reperfusion injury and antibody mediated rejection. Furthermore, the complement system plays critical roles in modulating the responses of T cells and B cells to antigens. Therapeutic complement inhibitors, therefore, may be effective for protecting transplanted organs from several causes of inflammatory injury. Although several anti-complement drugs have shown promise in selected patients, the role of these drugs in transplantation medicine requires further study. (Copyright © 2019 Grafals and Thurman.) |
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| معلومات مُعتمدة: | R01 DK076690 United States DK NIDDK NIH HHS; R01 DK113586 United States DK NIDDK NIH HHS |
| فهرسة مساهمة: | Keywords: alloimmunity; antibody mediated allograft rejection; complement; delayed graft function; therapeutics; transplantation |
| المشرفين على المادة: | 0 (Receptors, Complement) 9007-36-7 (Complement System Proteins) |
| تواريخ الأحداث: | Date Created: 20191023 Date Completed: 20201103 Latest Revision: 20201103 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6788431 |
| DOI: | 10.3389/fimmu.2019.02380 |
| PMID: | 31636644 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2019.02380 |