دورية أكاديمية
Prenatal folate, homocysteine and vitamin B 12 levels and child brain volumes, cognitive development and psychological functioning: the Generation R Study.
| العنوان: | Prenatal folate, homocysteine and vitamin B |
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| المؤلفون: | Ars CL; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Nijs IM; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Marroun HE; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Muetzel R; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Schmidt M; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Steenweg-de Graaff J; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., van der Lugt A; Department of Radiology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Jaddoe VW; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Paediatrics, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Hofman A; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Steegers EA; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Verhulst FC; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., Tiemeier H; Generation R Study Group, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Psychiatry, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands., White T; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands.; Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam 3000 CB, The Netherlands. |
| المصدر: | The British journal of nutrition [Br J Nutr] 2019 Sep; Vol. 122 (s1), pp. S1-S9. Date of Electronic Publication: 2016 Jan 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: [Cambridge, New York] Cambridge University Press. |
| مواضيع طبية MeSH: | Brain/*growth & development , Cognition Disorders/*epidemiology , Folic Acid Deficiency/*complications , Homocysteine/*blood , Pregnancy Complications/*physiopathology , Vitamin B 12 Deficiency/*complications, Brain/diagnostic imaging ; Child ; Child Behavior Disorders/epidemiology ; Cohort Studies ; Female ; Folic Acid/blood ; Humans ; Language Development Disorders/epidemiology ; Magnetic Resonance Imaging ; Male ; Netherlands/epidemiology ; Pregnancy ; Prenatal Exposure Delayed Effects/epidemiology ; Prospective Studies ; Vitamin B 12/blood |
| مستخلص: | Previous studies have suggested that prenatal maternal folate deficiency is associated with reduced prenatal brain growth and psychological problems in offspring. However, little is known about the longer-term impact. The aims of this study were to investigate whether prenatal maternal folate insufficiency, high total homocysteine levels and low vitamin B12 levels are associated with altered brain morphology, cognitive and/or psychological problems in school-aged children. This study was embedded in Generation R, a prospective population-based cohort study. The study sample consisted of 256 Dutch children aged between 6 and 8 years from whom structural brain scans were collected using MRI. The mothers of sixty-two children had insufficient (<8 nmol/l) plasma folate concentrations in early pregnancy. Cognitive development was assessed by the Snijders-Oomen Niet-verbale intelligentietest - Revisie and the NEPSY-II-NL. Psychological problems were assessed at age 6 years using the parent report of the Child Behavior Checklist. Low prenatal folate levels were associated with a smaller total brain volume (B -33·34; 95 % CI -66·7, 0·02; P=050) and predicted poorer performance on the language (B -0·28; 95 % CI -0·52, -0·04; P=0·020) and visuo-spatial domains (B -0·27; 95 % CI -0·50, -0·04; P=0·021). High homocysteine levels (>9·1 µmol/l) predicted poorer performance on the language (B -0·31; 95 % CI -0·56, -0·06; P=0·014) and visuo-spatial domains (B -0·36; 95 % CI -0·60, -0·11; P=0·004). No associations with psychological problems were found. Our findings suggest that folate insufficiency in early pregnancy has a long-lasting, global effect on brain development and is, together with homocysteine levels, associated with poorer cognitive performance. |
| فهرسة مساهمة: | Keywords: Brain development; Children; Cognition; Epidemiology; Folic acid; Intelligence; MRI |
| المشرفين على المادة: | 0LVT1QZ0BA (Homocysteine) 935E97BOY8 (Folic Acid) P6YC3EG204 (Vitamin B 12) |
| تواريخ الأحداث: | Date Created: 20191023 Date Completed: 20200511 Latest Revision: 20200511 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1017/S0007114515002081 |
| PMID: | 31638501 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2662 |
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| DOI: | 10.1017/S0007114515002081 |