دورية أكاديمية
Passiflora edulis Leaf Extract: Evidence of Antidiabetic and Antiplatelet Effects in Rats.
| العنوان: | Passiflora edulis Leaf Extract: Evidence of Antidiabetic and Antiplatelet Effects in Rats. |
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| المؤلفون: | Salles BCC; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas., da Silva MA; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas., Taniguthi L; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas., Ferreira JN; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas., da Rocha CQ; Department of Chemistry, Federal University of Maranhão., Vilegas W; Institute of Biosciences, State University of São Paulo, Coastal Campus of São Vicente., Dias PH; Institute of Biosciences, State University of São Paulo, Coastal Campus of São Vicente., Pennacchi PC; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, University of São Paulo., Duarte SMDS; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas., Rodrigues MR; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas., Brigagão MRPL; Institute of Biomedical Sciences, Federal University of Alfenas., Paula FBA; Department of Clinical Analysis and Toxicology, College of Pharmaceutical Sciences, Federal University of Alfenas. |
| المصدر: | Biological & pharmaceutical bulletin [Biol Pharm Bull] 2020 Jan 01; Vol. 43 (1), pp. 169-174. Date of Electronic Publication: 2019 Oct 22. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 9311984 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-5215 (Electronic) Linking ISSN: 09186158 NLM ISO Abbreviation: Biol Pharm Bull Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo : Pharmaceutical Society of Japan, c1993- |
| مواضيع طبية MeSH: | Hypoglycemic Agents/*pharmacology , Passiflora/*chemistry , Plant Extracts/*pharmacology , Plant Leaves/*chemistry , Platelet Aggregation Inhibitors/*pharmacology, Alloxan/pharmacology ; Animals ; Diabetes Complications/blood ; Diabetes Complications/drug therapy ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/drug therapy ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/therapeutic use ; Male ; Plant Extracts/isolation & purification ; Plant Extracts/therapeutic use ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/isolation & purification ; Platelet Aggregation Inhibitors/therapeutic use ; Rats, Wistar |
| مستخلص: | Different Passiflora species have been appointed as a promising herbal medicine due to antioxidant properties; however, their effect on oxidative process induced by diabetes is still controversial. We aimed to evaluate effects of hydroethanolic extract 70% from P. edulis leaf on biochemical blood markers, collagen glycation, production of oxidant species and platelet aggregation in diabetic rats. The phytochemical analysis of the extract was performed by dereplication using LC coupled to the Photodiode Array Detector and Mass Spectrometer detector. Male Wistar rats were assigned to the control group and groups treated with alloxan (150 mg/kg) intraperitoneally, extract (200 mg/kg/d, for 90 d) and combination of alloxan and extract. The phytochemical analysis suggested the presence of flavonoids C-glycosides in the extract. The diabetic animals treated with the extract presented improvement in glycaemic control, reduced glycation collagen, levels of non-high density lipoprotein (non-HDL) cholesterol, total cholesterol and creatinine, production of oxidant species and aggregation in platelet in relation to diabetic animals non-treated. Our results showed that P. edulis leaf extract presents a health benefit to the diabetic state, preventing the appearance of its complications. Its effect can be associated with flavonoids, among which is the flavonoid C-glycoside isoorientin. |
| فهرسة مساهمة: | Keywords: Passiflora edulis; biochemical marker; diabetes mellitus; isoorientin; platelet aggregation; quantification |
| المشرفين على المادة: | 0 (Hypoglycemic Agents) 0 (Plant Extracts) 0 (Platelet Aggregation Inhibitors) 6SW5YHA5NG (Alloxan) |
| تواريخ الأحداث: | Date Created: 20191025 Date Completed: 20200923 Latest Revision: 20200923 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1248/bpb.b18-00952 |
| PMID: | 31645529 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1347-5215 |
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| DOI: | 10.1248/bpb.b18-00952 |