دورية أكاديمية
Effect of bilateral sympathectomy in a rat model of dilated cardiomyopathy induced by doxorubicin.
| العنوان: | Effect of bilateral sympathectomy in a rat model of dilated cardiomyopathy induced by doxorubicin. |
|---|---|
| المؤلفون: | Coutinho E Silva RDS; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Zanoni FL; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Simas R; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Martins da Silva MHF; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Armstrong Junior R; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Correia CJ; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Breithaupt Faloppa AC; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Moreira LFP; Laboratório Cirúrgico de Pesquisa Cardiovascular (LIM-11), Instituto do Coração (Incor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil. Electronic address: luiz.moreira@incor.usp.br. |
| المصدر: | The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2020 Sep; Vol. 160 (3), pp. e135-e144. Date of Electronic Publication: 2019 Sep 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 0376343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-685X (Electronic) Linking ISSN: 00225223 NLM ISO Abbreviation: J Thorac Cardiovasc Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: St. Louis, MO : Mosby Original Publication: St. Louis. |
| مواضيع طبية MeSH: | Sympathectomy*, Cardiomyopathy, Dilated/*chemically induced , Cardiomyopathy, Dilated/*surgery , Doxorubicin/*toxicity, Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Disease Models, Animal ; Enalapril/administration & dosage ; Humans ; Male ; Rats ; Rats, Wistar ; Ventricular Dysfunction, Left/prevention & control ; Ventricular Remodeling |
| مستخلص: | Objective: The study objective was to evaluate the effect of bilateral sympathectomy on ventricular remodeling and function in a rat model of dilated cardiomyopathy induced by doxorubicin. Methods: Dilated cardiomyopathy was induced in male Wistar rats by weekly intraperitoneal injection of doxorubicin (2 mg/kg) for 9 weeks. Animals were divided into 4 groups: dilated cardiomyopathy; bilateral sympathectomy, submitted on day 15 of the protocol to bilateral sympathectomy; angiotensin-converting enzyme inhibitor, treated with enalapril through day 15 until the end of the experimental protocol; and sham, nonsubmitted through doxorubicin protocol, with weekly intraperitoneal injections of saline solution (0.9%). The left ventricular function was assessed, and the heart was collected for posterior analyses. Results: The dilated cardiomyopathy group presented a significant decrease in the myocardial efficiency when compared with the sham group (33.4% vs 71.2%). Only the bilateral sympathectomy group was able to preserve it (57.5%; P = .0001). A significant dilatation in the left ventricular chamber was observed in the dilated cardiomyopathy group (15.9 μm 2 ) compared with the sham group (10.2 μm 2 ; P = .0053). Sympathectomy and enalapril prevented ventricular remodeling (9.5 and 9.6 μm 2 , respectively; P = .0034). There was a significant increase in interstitial myocardial fibrosis in the dilated cardiomyopathy group (14.8%) when compared with the sham group (2.4%; P = .0001). This process was significantly reduced with sympathectomy and enalapril (8.7 and 3.9%, respectively; P = .0001). Conclusions: Bilateral sympathectomy was effective in preventing remodeling and left ventricular dysfunction in a rat model of dilated cardiomyopathy induced by doxorubicin. (Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: J Thorac Cardiovasc Surg. 2020 Sep;160(3):e147. (PMID: 31630843) Comment in: J Thorac Cardiovasc Surg. 2020 Sep;160(3):e145-e146. (PMID: 31761349) |
| فهرسة مساهمة: | Keywords: apoptosis; dilated cardiomyopathy; doxorubicin; left ventricular function; left ventricular remodeling; sympathectomy |
| المشرفين على المادة: | 0 (Angiotensin-Converting Enzyme Inhibitors) 69PN84IO1A (Enalapril) 80168379AG (Doxorubicin) |
| تواريخ الأحداث: | Date Created: 20191027 Date Completed: 20200831 Latest Revision: 20200831 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.jtcvs.2019.09.031 |
| PMID: | 31653422 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1097-685X |
|---|---|
| DOI: | 10.1016/j.jtcvs.2019.09.031 |