دورية أكاديمية
أعرض في EDS

Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3-(phenylselanyl)-1H-indole.

التفاصيل البيبلوغرافية
العنوان: Depression-like behavior, hyperglycemia, oxidative stress, and neuroinflammation presented in diabetic mice are reversed by the administration of 1-methyl-3-(phenylselanyl)-1H-indole.
المؤلفون: Bampi SR; Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Casaril AM; Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Domingues M; Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., de Andrade Lourenço D; Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Pesarico AP; Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Vieira B; Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, RS, Brazil., Begnini KR; Cellular and Molecular Oncology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Seixas FK; Cellular and Molecular Oncology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Collares TV; Cellular and Molecular Oncology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil., Lenardão EJ; Laboratory of Clean Organic Synthesis, Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, RS, Brazil., Savegnago L; Neurobiotechnology Research Group, Center of Biotechnology, Federal University of Pelotas, RS, Brazil. Electronic address: luciellisavegnago@yahoo.com.br.
المصدر: Journal of psychiatric research [J Psychiatr Res] 2020 Jan; Vol. 120, pp. 91-102. Date of Electronic Publication: 2019 Oct 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Pergamon Press
مواضيع طبية MeSH: Behavior, Animal/*drug effects , Cerebral Cortex/*drug effects , Depression/*drug therapy , Diabetes Mellitus, Experimental/*drug therapy , Hyperglycemia/*drug therapy , Indoles/*pharmacology , Inflammation/*drug therapy , Organoselenium Compounds/*pharmacology, Animals ; Depression/blood ; Depression/immunology ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/immunology ; Hippocampus/drug effects ; Hyperglycemia/blood ; Hyperglycemia/immunology ; Indoles/administration & dosage ; Inflammation/blood ; Inflammation/immunology ; Kidney/drug effects ; Liver/drug effects ; Mice ; Organoselenium Compounds/administration & dosage ; Selenium
مستخلص: Oxidative stress and neuroinflammation are found both in diabetes mellitus and major depressive disorder (MDD). In addition to damage in peripheral organs, such as liver and kidney, diabetic patients have a higher risk of developing depression. In this sense, the objective of the present study was to characterize the antidepressant-like effect of a selenium-containing compound, the 1-methyl-3-(phenylselanyl)-1H-indole (MFSeI), in streptozotocin (STZ)-induced diabetic mice. STZ (200 mg/kg, i.p.) was used to induce diabetes mellitus type I, and after seven days, the administration of MFSeI (10 mg/kg, i.g.) was initiated and followed for the next 14 days. Twenty-four hours after the last administration of MFSeI, the behavioral tests were performed, followed by euthanasia. The treatment with MFSeI was able to reverse the hyperglycemia induced by STZ. MFSeI also decreased the plasma levels of biomarkers of liver and kidney damage. Importantly, MFSeI reversed the depression-like behavior induced by STZ in the tail suspension test and forced swimming test without promoting locomotor alterations. Furthermore, MFSeI reversed the increased levels of reactive species and lipid peroxidation in the prefrontal cortex (PFC), hippocampus (HC), liver, and kidney of STZ-treated mice. Treatment with MFSeI also decreased the expression of tumor necrosis factor-alpha, inducible nitric oxide synthase and indoleamine 2,3-dioxygenase, while increasing the expression of interleukin-10, insulin receptor substrate-1 and glucose transport-4 in the PFC and HC of mice. Taken together, the results indicate the effectiveness of MFSeI against depression-like behavior and central and peripheral complications caused by diabetes in mice.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Depression; Diabetes; Organoselenium; Selenium; Streptozotocin
المشرفين على المادة: 0 (Indoles)
0 (Organoselenium Compounds)
H6241UJ22B (Selenium)
تواريخ الأحداث: Date Created: 20191027 Date Completed: 20210324 Latest Revision: 20210324
رمز التحديث: 20231215
DOI: 10.1016/j.jpsychires.2019.10.003
PMID: 31654972
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1379
DOI:10.1016/j.jpsychires.2019.10.003