دورية أكاديمية
أعرض في EDS

Entomotoxic Activity of Prasiola crispa (Antarctic Algae) in Nauphoeta cinerea Cockroaches: Identification of Main Steroidal Compounds.

التفاصيل البيبلوغرافية
العنوان: Entomotoxic Activity of Prasiola crispa (Antarctic Algae) in Nauphoeta cinerea Cockroaches: Identification of Main Steroidal Compounds.
المؤلفون: Holken Lorensi G; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. grazielahl@gmail.com., Soares Oliveira R; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. raquelsoaresoliveira@yahoo.com.br., Leal AP; Programa de Pós-Graduação em Bioquímica Toxicológica, PPGBtox, Universidade Federal de Santa Maria, UFSM, Bairro Camobi, Santa Maria, RS 9705-900, Brazil. allan-leal@hotmail.com., Zanatta AP; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. anapaulabiotech@gmail.com., Moreira de Almeida CG; Instituto do Cérebro (INSCER), Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. carlos.gabriel@acad.pucrs.br., Barreto YC; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. barreto78@outlook.com., Eduarda Rosa M; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. rosaedumaria@gmail.com., de Brum Vieira P; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. patriciasbrum@yahoo.com.br.; Grupo de Pesquisa em Estresse Oxidativo e Sinalização Celular, Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. patriciasbrum@yahoo.com.br., Brito Ramos CJ; Programa de Pós-Graduação em Biodiversidade Neotropical, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ 22290-255, Brazil. cjbramos@gmail.com., de Carvalho Victoria F; Núcleo de Estudos da Vegetação Antártica (NEVA), Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul 97307-020, Brazil. filipevictoria@unipampa.edu.br., Batista Pereira A; Núcleo de Estudos da Vegetação Antártica (NEVA), Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, Rio Grande do Sul 97307-020, Brazil. antoniopereira@unipampa.edu.br., LaneuvilleTeixeira V; Programa de Pós-Graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense, Centro, Niterói, RJ 24020-141, Brazil. valerialaneuville@gmail.com.; Programa de Pós-Graduação em Biodiversidade Neotropical, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ 22290-255, Brazil. valerialaneuville@gmail.com., Dal Belo CA; Laboratório de Neurobiologia e Toxinologia (LANETOX),Universidade Federal do Pampa, Campus São Gabriel, São Gabriel, RS 97307-020, Brazil. charistonbelo@unipampa.edu.br.; Programa de Pós-Graduação em Bioquímica Toxicológica, PPGBtox, Universidade Federal de Santa Maria, UFSM, Bairro Camobi, Santa Maria, RS 9705-900, Brazil. charistonbelo@unipampa.edu.br.
المصدر: Marine drugs [Mar Drugs] 2019 Oct 10; Vol. 17 (10). Date of Electronic Publication: 2019 Oct 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Cockroaches*, Chlorophyta/*chemistry , Insecticides/*chemistry , Phytosterols/*analysis , Plant Extracts/*chemistry, Animals ; Antarctic Regions ; Hexanes/chemistry ; Insecticides/isolation & purification ; Lethal Dose 50 ; Plant Extracts/isolation & purification
مستخلص: Prasiola crispa is a macroscopic green algae found in abundance in Antarctica ice free areas. Prasiola crispan -hexaneextract (HPC) induced insecticidal activity in Nauphoeta cinerea cockroaches after 24 h of exposure. The chemical analysis of HPC revealed the presence of the followingphytosterols: β-sitosterol, campesterol and stigmasterol. The incubation of cockroach semi-isolated heart preparations with HPC caused a significant negative chronotropic activity in the heartbeats. HPC affected the insect neuromuscular function by inducing a complete inhibition of the cockroach leg-muscle twitch tension. When the isolated phytosterols were injected at in vivo cockroach neuromuscular preparations, there was a progressive inhibition of muscle twitches on the following order of potency: β-sitosterol > campesterol > stigmasterol. HPC also provoked significant behavioral alterations, characterized by the increase or decrease of cockroach grooming activity, depending on the dose assayed. Altogether, the results presented here corroborate the insecticide potential of Prasiola crispa Antarctic algae. They also revealed the presence of phytosterols and the involvement of these steroidal compounds in the entomotoxic activity of the algae, potentially by modulating octopaminergic-cholinergic pathways. Further phytochemical-combined bioguided analysis of the HPC will unveil novel bioactive compounds that might be an accessory to the insecticide activity of the algae.
References: PLoS One. 2010 Apr 07;5(4):e10019. (PMID: 20383324)
In Vitro Cell Dev Biol Anim. 2001 Jul-Aug;37(7):445-9. (PMID: 11573820)
Comp Gen Pharmacol. 1971 Sep;2(7):347-71. (PMID: 4353991)
Pestic Biochem Physiol. 2018 Jun;148:175-181. (PMID: 29891370)
J Physiol. 1981 Sep;318:99-122. (PMID: 6275071)
Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051)
Int Sch Res Notices. 2014 Oct 19;2014:967361. (PMID: 27382622)
Toxicology. 2016 Aug 10;368-369:162-171. (PMID: 27640743)
Ecotoxicol Environ Saf. 2014 Nov;109:56-62. (PMID: 25164203)
Comp Gen Pharmacol. 1970 Dec;1(4):426-30. (PMID: 5527577)
J Insect Physiol. 1968 Dec;14(12):1713-7. (PMID: 5733973)
J Neurobiol. 1985 May;16(3):171-81. (PMID: 3925079)
J Lipid Res. 2002 Jul;43(7):1114-24. (PMID: 12091496)
Pest Manag Sci. 2007 Jan;63(1):75-83. (PMID: 17173345)
Ecotoxicol Environ Saf. 2019 Apr 30;171:138-145. (PMID: 30599431)
Invert Neurosci. 2005 Nov;5(3-4):111-8. (PMID: 16211376)
J Phycol. 2017 Aug;53(4):908-915. (PMID: 28394430)
Front Pharmacol. 2017 Oct 06;8:697. (PMID: 29056913)
Biologics. 2017 Aug 02;11:107-114. (PMID: 28814827)
J Insect Physiol. 2011 Feb;57(2):316-25. (PMID: 21147117)
Nat Commun. 2017 Feb 21;8:14505. (PMID: 28220900)
Neurochem Res. 1993 Aug;18(8):869-74. (PMID: 8371829)
J Toxicol Environ Health A. 2014;77(1-3):115-24. (PMID: 24555652)
J Exp Biol. 1998 Apr;201 (Pt 7):997-1012. (PMID: 9487104)
Pharmacol Ther. 1996;69(2):117-42. (PMID: 8984507)
J Eukaryot Microbiol. 1993 May-Jun;40(3):244-6. (PMID: 8508162)
J Exp Biol. 1999 Apr;202 (Pt 8):957-64. (PMID: 10085268)
Nat Prod Rep. 2013 Oct 11;30(11):1380-90. (PMID: 23982267)
Biochim Biophys Acta Gen Subj. 2017 Mar;1861(3):541-550. (PMID: 27916676)
معلومات مُعتمدة: Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 063/2010 Toxinologia Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 003/2011 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 187/2018 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; 301964/2018 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 05/2019 Universidade Federal do Pampa
فهرسة مساهمة: Keywords: Antarctic algae; biological activity; insecticide; marine natural products; marine steroids
المشرفين على المادة: 0 (Hexanes)
0 (Insecticides)
0 (Phytosterols)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20191030 Date Completed: 20200320 Latest Revision: 20200320
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6835979
DOI: 10.3390/md17100573
PMID: 31658661
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md17100573