دورية أكاديمية
Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review.
| العنوان: | Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review. |
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| المؤلفون: | Hegazy MF; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany.; Department of Phytochemistry, National Research Centre, Giza, Egypt., Elshamy AI; Department of Natural Compounds Chemistry, National Research Centre, Giza, Egypt.; Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima, Japan., Mohamed TA; Department of Phytochemistry, National Research Centre, Giza, Egypt., Hussien TA; Pharmacognosy Department, Faculty of Pharmacy, Deraya University, Minia, Egypt., Helaly SE; Department of Microbial Drugs, Helmholtz Centre for Infection Research, Braunschweig, Germany.; Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt., Abdel-Azim NS; Department of Phytochemistry, National Research Centre, Giza, Egypt., Shams KA; Department of Phytochemistry, National Research Centre, Giza, Egypt., Shahat AA; Department of Phytochemistry, National Research Centre, Giza, Egypt., Tawfik WA; Department of Phytochemistry, National Research Centre, Giza, Egypt., Shahen AM; Department of Phytochemistry, National Research Centre, Giza, Egypt., Debbab A; Debbab Med, Munich, Germany., El Saedi HR; Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.; Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, Egypt., Mohamed AEH; Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt., Hammouda FM; Department of Phytochemistry, National Research Centre, Giza, Egypt., Sakr M; Genetic Engineering and Biotech. Division, National Research Centre, Giza, Egypt.; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, USA., Paré PW; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, USA., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany. |
| المصدر: | Critical reviews in biotechnology [Crit Rev Biotechnol] 2020 Feb; Vol. 40 (1), pp. 64-82. Date of Electronic Publication: 2019 Oct 30. |
| نوع المنشور: | Journal Article; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8505177 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-7801 (Electronic) Linking ISSN: 07388551 NLM ISO Abbreviation: Crit Rev Biotechnol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton, Fla. : CRC Press, c1983- |
| مواضيع طبية MeSH: | Plants/*metabolism , Terpenes/*metabolism, Biotransformation ; Cell Culture Techniques ; Plant Structures/metabolism |
| مستخلص: | Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988-2019). |
| فهرسة مساهمة: | Keywords: Pharmaceutical products; Terpenoid; active natural product derivatives; enzymatic biotransformations; natural metabolites; plant cell cultures |
| المشرفين على المادة: | 0 (Terpenes) |
| تواريخ الأحداث: | Date Created: 20191031 Date Completed: 20200409 Latest Revision: 20200409 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/07388551.2019.1681932 |
| PMID: | 31663377 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1549-7801 |
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| DOI: | 10.1080/07388551.2019.1681932 |