دورية أكاديمية
[Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia].
| العنوان: | [Effects of сramizol on expression of the ApoA1 gene in rats with experimental hyperlipidemia]. |
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| عنوان ترانسليتريتد: | Vliianie kramizola na ékspressiiu gena apolipoproteina A1 (ApoA1) v pecheni krys pri éksperimental'no indutsirovannoĭ giperlipidemii. |
| المؤلفون: | Lizunov AV; Institute of Experimental Medicine, St. Petersburg, Russia; St Petersburg University, St. Petersburg, Russia., Okunevich IV; Institute of Experimental Medicine, St. Petersburg, Russia., Orlov SV; Institute of Experimental Medicine, St. Petersburg, Russia; St Petersburg University, St. Petersburg, Russia., Lebedev AA; Institute of Experimental Medicine, St. Petersburg, Russia., Bychkov ER; Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia., Piotrovskiy LB; Institute of Experimental Medicine, St. Petersburg, Russia., Shabanov PD; Institute of Experimental Medicine, St. Petersburg, Russia; Kirov Military Medical Academy, St. Petersburg, Russia. |
| المصدر: | Biomeditsinskaia khimiia [Biomed Khim] 2019 Aug; Vol. 65 (5), pp. 403-406. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk Country of Publication: Russia (Federation) NLM ID: 101196966 Publication Model: Print Cited Medium: Print ISSN: 2310-6972 (Print) Linking ISSN: 23106905 NLM ISO Abbreviation: Biomed Khim Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Rossiĭskai︠a︡ akademii︠a︡ medit︠s︡inskikh nauk, 2003- |
| مواضيع طبية MeSH: | Apolipoprotein A-I/*genetics , Hyperlipidemias/*drug therapy , Hypolipidemic Agents/*pharmacology , Imidazoles/*pharmacology, Animals ; Cholesterol/blood ; Fenofibrate ; Hyperlipidemias/genetics ; Rats ; Triglycerides/blood |
| مستخلص: | An imidazole derivative cramizol, has lipid-lowering and anti-atherogenic effects. Cramizol reduces blood levels of cholesterol and triglycerides, and also reduces the atherogenic index in animals with acute hyperlipidemia induced by Triton WR-1339. Cramizol and the lipid-lowering drug fenofibrate exhibited similar effectiveness as hypolipidemic agents. Cramizol also restores the expression of the Apoa1 gene in rats with experimentally induced hyperlipidemia to normal values. This may be a basis of its hypolipidemic and anti-atherogenic action. |
| فهرسة مساهمة: | Keywords: Triton WR-1339; apolipoprotein A1; cholesterol; cramizol; experimental hyperlipidemia; triglycerides Local Abstract: [Publisher, Russian] Proizvodnoe imidazola kramizol obladaet tsitoprotektornym, gipolipidemicheskim i antiaterogennym deĭstviem. Na modeli ostroĭ giperlipidemii, indutsirovannoĭ detergentom tritonom WR-1339, étot preparat snizhaet soderzhanie kholesterina i triglitseridov v krovi, a takzhe znachitel'no umen'shaet kholesterinovyĭ indeks aterogennosti. Po vyrazhennosti gipolipidemicheskogo deĭstviia kramizol sootvetstvuet étalonnomu gipolipidemicheskomu preparatu fenofibratu. Kramizol takzhe vosstanavlivaet do normal'nykh znacheniĭ ékspressiiu gena Apoa1 v pecheni u krys s éksperimental'no indutsirovannoĭ ostroĭ giperlipidemieĭ, chto, vozmozhno, iavliaetsia osnovoĭ ego gipolipidemicheskogo i antiaterogennogo deĭstviia. |
| المشرفين على المادة: | 0 (Apolipoprotein A-I) 0 (Hypolipidemic Agents) 0 (Imidazoles) 0 (Triglycerides) 97C5T2UQ7J (Cholesterol) U202363UOS (Fenofibrate) |
| تواريخ الأحداث: | Date Created: 20191101 Date Completed: 20191111 Latest Revision: 20221222 |
| رمز التحديث: | 20221222 |
| DOI: | 10.18097/PBMC20196505403 |
| PMID: | 31666413 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2310-6972 |
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| DOI: | 10.18097/PBMC20196505403 |