دورية أكاديمية
Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.
| العنوان: | Homeostatic Function of Dermokine in the Skin Barrier and Inflammation. |
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| المؤلفون: | Utsunomiya A; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Chino T; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Utsunomiya N; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Luong VH; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Tokuriki A; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Naganuma T; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Arita M; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Higashi K; Sumitomo Chemical Co., Ltd. Cell Science Group Environmental Health Science Laboratory, Osaka, Japan., Saito K; Sumitomo Chemical Co., Ltd. Cell Science Group Environmental Health Science Laboratory, Osaka, Japan., Suzuki N; Sumitomo Chemical Co., Ltd. Cell Science Group Environmental Health Science Laboratory, Osaka, Japan., Ohara A; Sumitomo Chemical Co., Ltd. Cell Science Group Environmental Health Science Laboratory, Osaka, Japan., Sugai M; Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Sugawara K; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan., Tsuruta D; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan., Oyama N; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan., Hasegawa M; Department of Dermatology, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan. Electronic address: minoruha@u-fukui.ac.jp. |
| المصدر: | The Journal of investigative dermatology [J Invest Dermatol] 2020 Apr; Vol. 140 (4), pp. 838-849.e9. Date of Electronic Publication: 2019 Oct 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Epidermis/*metabolism , Ichthyosis, Lamellar/*metabolism , Intercellular Signaling Peptides and Proteins/*metabolism , Keratinocytes/*metabolism, Animals ; Cell Differentiation ; Disease Models, Animal ; Epidermis/pathology ; Homeostasis ; Ichthyosis, Lamellar/immunology ; Ichthyosis, Lamellar/pathology ; Keratinocytes/pathology ; Mice |
| مستخلص: | Dermokine is a chiefly skin-specific secreted glycoprotein localized in the upper epidermis, and its family consists of three splice variants in mice and five in humans. To investigate the pathophysiological impact of dermokine, we generated mice deficient for two (βγ) or all dermokine isoforms (αβγ). Both variants, especially dermokine αβγ-deficient mice exhibited scale and wrinkle formation resembling ichthyosis accompanied by transepidermal water imbalance at the neonatal stage. Several dermokine αβγ-deficient mice died by postnatal day 21 when reared under low humidity. Moreover, the cornified envelope was vulnerable, and skin barrier lipid ceramides were reduced in the epidermis of dermokine αβγ-deficient mice. cDNA microarray and quantitative reverse transcriptase-PCR assays of the epidermis revealed the upregulation of small proline-rich protein and late cornified envelope family members, as well as antimicrobial peptides in the dermokine αβγ-deficient mice. These barrier gene signatures were similar to that seen in psoriasis, whereas recent studies demonstrated that congenital ichthyosis has gene profiles resembling psoriasis. In line with these findings, adult dermokine αβγ-deficient mice exhibited aggravated phenotypes in psoriasis-like dermatitis models but not in allergic dermatitis models. Dermokine may play a regulatory role in inflammatory dyskeratotic diseases, such as congenital ichthyosis and psoriasis, in the crosstalk between barrier dysfunction and inflammation. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Intercellular Signaling Peptides and Proteins) 0 (dermokine protein, mouse) |
| تواريخ الأحداث: | Date Created: 20191101 Date Completed: 20201103 Latest Revision: 20201103 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jid.2019.09.011 |
| PMID: | 31669414 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1523-1747 |
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| DOI: | 10.1016/j.jid.2019.09.011 |