دورية أكاديمية
أعرض في EDS

Prevalence and outcome of central airway obstruction in patients with lung cancer.

التفاصيل البيبلوغرافية
العنوان: Prevalence and outcome of central airway obstruction in patients with lung cancer.
المؤلفون: Daneshvar C; Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK., Falconer WE; Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK., Ahmed M; Interventional Respiratory Unit, Galway University Hospitals, Galway, Ireland., Sibly A; Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK., Hindle M; Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK., Nicholson TW; Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK., Aldik G; Respiratory Medicine, Plymouth Hospitals NHS Trust, Plymouth, UK., Telisinghe LA; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Riordan RD; Imaging, Plymouth Hospitals NHS Trust, Plymouth, UK., Marchbank A; Cardiothoracic Surgery, Plymouth Hospitals NHS Trust, Plymouth, UK., Breen D; Respiratory, Galway University Hospital, Galway, Ireland.
المصدر: BMJ open respiratory research [BMJ Open Respir Res] 2019 Sep 24; Vol. 6 (1), pp. e000429. Date of Electronic Publication: 2019 Sep 24 (Print Publication: 2019).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BMJ Publishing Group Ltd & British Thoracic Society Country of Publication: England NLM ID: 101638061 Publication Model: eCollection Cited Medium: Print ISSN: 2052-4439 (Print) Linking ISSN: 20524439 NLM ISO Abbreviation: BMJ Open Respir Res
أسماء مطبوعة: Original Publication: London : BMJ Publishing Group Ltd & British Thoracic Society, [2013]-
مواضيع طبية MeSH: Cost of Illness*, Airway Obstruction/*epidemiology , Lung Neoplasms/*complications, Aged ; Aged, 80 and over ; Airway Obstruction/diagnosis ; Airway Obstruction/etiology ; Airway Obstruction/therapy ; Bronchoscopy/statistics & numerical data ; Female ; Follow-Up Studies ; Humans ; Incidence ; Kaplan-Meier Estimate ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Prevalence ; United Kingdom/epidemiology
مستخلص: Introduction: Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence of CAO in lung cancer patients is unknown. We audited CAO burden to inform our local cancer service.
Methods: This is a cohort review of all new lung cancer diagnoses between 1 November 2014 and 30 November 2015. CAO was defined by CT appearance. CT scans and routine patient records were followed up to 30 November 2018 to determine the prevalence of CAO at diagnosis; the characteristics of patients with prevalent CAO; mortality (using survival analysis); and incident CAO over follow-up.
Results: Of 342 new lung cancer diagnoses, CAO prevalence was 13% (95% CI 10% to 17%; n=45/342). Dedicated CT scan review identified missed CAO in 14/45 (31%) cases. In patients with prevalent CAO, 27/44 (61%) had a performance status of ≤2, 23/45 (51%) were diagnosed during an acute admission and 36/44 (82%) reported symptoms. Treatments were offered to 32/45 (71%); therapeutic bronchoscopy was performed in only 8/31 (26%) eligible patients. Median survival of patients with prevalent CAO was 94 (IQR 33-274) days. Multivariate analysis, adjusting for age, gender and disease stage, found CAO on index CT scan was independently associated with an increased hazard of death (adjusted HR 1.78 (95% CI 1.27 to 2.48); p=0.001). In total, 15/297 (5%) developed CAO during follow-up (median onset 340 (IQR 114-551) days). Over the audit period, 60/342 (18%; 95% CI 14% to 22%) had or developed CAO.
Discussions: This is the first description of CAO prevalence in 40 years. Patients with prevalent CAO had a higher mortality. Our data provide a benchmark for service planning.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
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معلومات مُعتمدة: MR/N020618/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: bronchoscopy; clinical epidemiology; imaging/CT MRI etc; lung cancer; non-small cell lung cancer; palliative care; small cell lung cancer; thoracic surgery
تواريخ الأحداث: Date Created: 20191102 Date Completed: 20200703 Latest Revision: 20210110
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6797367
DOI: 10.1136/bmjresp-2019-000429
PMID: 31673363
قاعدة البيانات: MEDLINE
الوصف
تدمد:2052-4439
DOI:10.1136/bmjresp-2019-000429