[Preoperative Lymphocyte-to-monocyte Ratio Predicts Prognosis in Patients with Stage T1 Non-muscle Invasive Bladder Cancer].

التفاصيل البيبلوغرافية
العنوان:	[Preoperative Lymphocyte-to-monocyte Ratio Predicts Prognosis in Patients with Stage T1 Non-muscle Invasive Bladder Cancer].
المؤلفون:	Wang QH; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Ji JL; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Li H; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., He PL; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Song LX; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Zhao Y; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Wang HY; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Huang T; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Sun XX; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Cao YW; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Dong Z; Department of Kidney Transplantation,Affiliated Hospital of Qingdao University,Qingdao,Shandong 266000,China., Shi BB; Department of Urology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
المصدر:	Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae [Zhongguo Yi Xue Ke Xue Yuan Xue Bao] 2019 Oct 30; Vol. 41 (5), pp. 622-629.
نوع المنشور:	Journal Article
اللغة:	Chinese
بيانات الدورية:	Publisher: Zhongguo yi xue ke xue yuan Country of Publication: China NLM ID: 8006230 Publication Model: Print Cited Medium: Print ISSN: 1000-503X (Print) Linking ISSN: 1000503X NLM ISO Abbreviation: Zhongguo Yi Xue Ke Xue Yuan Xue Bao Subsets: MEDLINE
أسماء مطبوعة:	Publication: Beijing : Zhongguo yi xue ke xue yuan Original Publication: [Beijing] Zhongguo yi xue ke xue yuan.
مواضيع طبية MeSH:	Lymphocytes/cytology , Monocytes/cytology , Urinary Bladder Neoplasms/*diagnosis, Disease-Free Survival ; Humans ; Prognosis ; Retrospective Studies ; Survival Rate ; Urinary Bladder Neoplasms/pathology
مستخلص:	Objective To investigate the clinical value of preoperative lymphocyte-to-monocyte ratio(LMR)in evaluating the prognosis of patients with stage T1 non-muscle invasive bladder cancer(NMIBC).Methods A total of 215 patients with stage T1 NMIBC who underwent transurethral resection of bladder tumor were enrolled.Clinical data were collected.Patients were followed up and their disease-free survival(DFS)and overall survival(OS)were recorded.The receiver operating characteristic(ROC)curve of preoperative LMR in detecting patient prognosis was used to determine the optimal cut-off value for LMR.Patients were divided into low LMR group(LMR <3.86, n =77)and high LMR group(LMR ≥ 3.86, n =138).Kaplan-Meier survival curves were explored to compare cumulative DFS and OS rates in patients with different LMR levels,and COX proportional hazards regression model was used to analyze factors associated with DFS and OS.Results All these 215 patients with T1 stage NMIBC were followed up for 2-92 months,and the DFS rate was 59.07% and OS rate was 65.12%.Kaplan-Meier curves showed that the cumulative DFS rate( χ ² =4.784, P =0.029)and cumulative OS rate( χ ² =7.146, P =0.008)in the low LMR group were significantly lower than those in the high LMR group.Tumor size ≥ 3 cm( HR =1.398,95% CI :1.042-1.875, P =0.025),pathological grade G3( HR =1.266,95% CI :1.026-1.563, P =0.028),and LMR ≥ 3.86( HR =2.347,95% CI :1.080-5.101, P =0.031)were independent factors associated with DFS in patients with stage T 1 NMIBC.In addition,tumor size ≥ 3 cm( HR =1.228,95% CI :1.015-1.484, P =0.034),pathological grade G3( HR =1.366,95% CI :1.017-1.834, P =0.038),and LMR<3.86( HR =2.008,95% CI :1.052-3.832, P =0.035)were independent factors associated with OS in patients with T1 stage NMIBC. Conclusion Preoperative LMR is an independent factor associated with patients' prognosis in T1 stage NIMBC.Patients with low LMR tend to have higher risk of NMIBC progression and death.
فهرسة مساهمة:	Keywords: T1 stage; lymphocyte; monocyte; non-muscle invasive bladder cancer; prognosis
تواريخ الأحداث:	Date Created: 20191109 Date Completed: 20191118 Latest Revision: 20200108
رمز التحديث:	20231215
DOI:	10.3881/j.issn.1000-503X.11227
PMID:	31699192
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1000-503X
DOI:	10.3881/j.issn.1000-503X.11227