دورية أكاديمية
The urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in Sprague-Dawley rats and the role of the metabolite methoxyacetic acid in their toxicity.
| العنوان: | The urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in Sprague-Dawley rats and the role of the metabolite methoxyacetic acid in their toxicity. |
|---|---|
| المؤلفون: | Kelsey JR; Chemsage Ltd, PO Box 431, Fleet, Hampshire, GU51 9BP, UK. Electronic address: kelseyjr@chemsage.co.uk., Cnubben NHP; Triskelion BV, Postal Address: P.O. Box 844, 3700 AV, Zeist, the Netherlands. Electronic address: nicole.cnubben@gmail.com., Bogaards JJP; Triskelion BV, Postal Address: P.O. Box 844, 3700 AV, Zeist, the Netherlands. Electronic address: jan.bogaards@triskelion.nl., Braakman RBH; Triskelion BV, Postal Address: P.O. Box 844, 3700 AV, Zeist, the Netherlands. Electronic address: rene.braakman@tno.nl., van Stee LLP; Triskelion BV, Postal Address: P.O. Box 844, 3700 AV, Zeist, the Netherlands. Electronic address: leo.vanstee@triskelion.nl., Smet K; Ineos Oxide, Safety, Health and Environment, Nieuwe Weg 1, 2070, Zwijndrecht, Belgium. Electronic address: karen.smet@ineos.com. |
| المصدر: | Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Feb; Vol. 110, pp. 104512. Date of Electronic Publication: 2019 Nov 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003>- : Amsterdam : Elsevier Original Publication: New York : Academic Press, [c1981- |
| مواضيع طبية MeSH: | Acetates/*urine , Ethylene Glycols/*pharmacokinetics , Methyl Ethers/*pharmacokinetics , Solvents/*pharmacokinetics, Acetates/toxicity ; Administration, Oral ; Animals ; Ethylene Glycols/toxicity ; Ethylene Glycols/urine ; Male ; Methyl Ethers/toxicity ; Methyl Ethers/urine ; Rats, Sprague-Dawley ; Solvents/toxicity |
| مستخلص: | Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol as the alcohol results in a series of mono, di and triethylene glycol methyl ethers. The first in the series, monoethylene glycol methyl ether (EGME or 2-methoxyethanol) is well characterised and metabolises in vivo to methoxyacetic acid (MAA), a known reproductive toxicant. Metabolism data is not available for the di and triethylene glycol ethers (DEGME and TEGME respectively). This study evaluated the metabolism of these two substances in male rats following single oral gavage doses of 500, 1000 and 2000 mg/kg for DEGME and 1000 mg/kg for TEGME. As for EGME, the dominant metabolite of each was the acid metabolite derived by oxidation of the terminal hydroxyl group. Elimination of these metabolites was rapid, with half-lives <4 h for each one. Both substances were also found to produce small amounts of MAA (~0.5% for TEGME and ~1.1% for DEGME at doses of 1000 mg/kg) through cleavage of the ether groups in the molecules. These small amounts of MAA produced can explain the effects seen at high doses in reproductive studies using DEGME and TEGME. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 2-(2-(2-methoxyethoxy)ethoxy)ethanol; 2-(2-methoxyethoxy)ethanol; 2-Methoxyacetic acid; DEGME; Glycol ethers; Metabolism; TEGME |
| المشرفين على المادة: | 0 (Acetates) 0 (Ethylene Glycols) 0 (Methyl Ethers) 0 (Solvents) F11T1H7Q7W (methoxyacetic acid) |
| تواريخ الأحداث: | Date Created: 20191110 Date Completed: 20200619 Latest Revision: 20200619 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.yrtph.2019.104512 |
| PMID: | 31704259 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0295 |
|---|---|
| DOI: | 10.1016/j.yrtph.2019.104512 |