دورية أكاديمية
أعرض في EDS

Early cortical maturation predicts neurodevelopment in very preterm infants.

التفاصيل البيبلوغرافية
العنوان: Early cortical maturation predicts neurodevelopment in very preterm infants.
المؤلفون: Kline JE; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Illapani VSP; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., He L; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Altaye M; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.; Division of Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Logan JW; Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA., Parikh NA; Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA nehal.parikh@cchmc.org.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
المصدر: Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2020 Sep; Vol. 105 (5), pp. 460-465. Date of Electronic Publication: 2019 Nov 08.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: British Medical Association Country of Publication: England NLM ID: 9501297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2052 (Electronic) Linking ISSN: 13592998 NLM ISO Abbreviation: Arch Dis Child Fetal Neonatal Ed Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : British Medical Association,
مواضيع طبية MeSH: Infant, Very Low Birth Weight*, Brain/*growth & development , Infant, Premature/*growth & development , Infant, Premature, Diseases/*physiopathology , Neurodevelopmental Disorders/*physiopathology, Biomarkers ; Brain/diagnostic imaging ; Child, Preschool ; Female ; Gestational Age ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Magnetic Resonance Imaging ; Male ; Prospective Studies ; Sex Factors ; Socioeconomic Factors
مستخلص: Objective: To evaluate the ability of four objectively defined, cortical maturation features-surface area, gyrification index, sulcal depth and curvature-from structural MRI at term-equivalent age (TEA) to independently predict cognitive and language development at 2 years corrected age in very preterm (VPT) infants.
Design: Population-based, prospective cohort study. Structural brain MRI was performed at term, between 40 and 44 weeks postmenstrual age and processed using the developing Human Connectome Project pipeline.
Setting: Multicentre study comprising four regional level III neonatal intensive care units in the Columbus, Ohio region.
Patients: 110 VPT infants (gestational age (GA) ≤ 31 weeks).
Main Outcome Measures: Cognitive and language scores at 2 years corrected age on the Bayley Scales of Infant and Toddler Development, Third Edition.
Results: Of the 94 VPT infants with high-quality T2-weighted MRI scans, 75 infants (80%) returned for Bayley-III testing. Cortical surface area was positively correlated with cognitive and language scores in nearly every brain region. Curvature of the inner cortex was negatively correlated with Bayley scores in the frontal, parietal and temporal lobes. In multivariable regression models, adjusting for GA, sex, socioeconomic status, and injury score on MRI, regional measures of surface area and curvature independently explained more than one-third of the variance in cognitive and language scores at 2 years corrected age in our cohort.
Conclusions: We identified increased cortical curvature at TEA as a new prognostic biomarker of adverse neurodevelopment in very premature infants. When combined with cortical surface area, it enhanced prediction of cognitive and language development. Larger studies are needed to externally validate our findings.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
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معلومات مُعتمدة: R01 NS094200 United States NS NINDS NIH HHS; R01 NS096037 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: neonatology; neurodevelopment; neurodisability; neurology; outcomes research
المشرفين على المادة: 0 (Biomarkers)
تواريخ الأحداث: Date Created: 20191110 Date Completed: 20200902 Latest Revision: 20210903
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7205568
DOI: 10.1136/archdischild-2019-317466
PMID: 31704737
قاعدة البيانات: MEDLINE
الوصف
تدمد:1468-2052
DOI:10.1136/archdischild-2019-317466