تقرير
أعرض في EDS

Isolated sporadic uterine lymphangioleiomyoma with unusual clinical and pathological features.

التفاصيل البيبلوغرافية
العنوان: Isolated sporadic uterine lymphangioleiomyoma with unusual clinical and pathological features.
المؤلفون: Leathersich S; Department of Obstetrics and Gynaecology, King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia sebastian.leathersich@health.wa.gov.au.; Department of Obstetrics and Gynaecology, Armadale Health Service, Armadale, Western Australia, Australia., Koay MHE; Department of Anatomical Pathology, PathWest Laboratory Medicine Western Australia, Subiaco, Western Australia, Australia., Khani A; Department of Anatomical Pathology, PathWest Laboratory Medicine Western Australia, Subiaco, Western Australia, Australia., Malla Bhat S; Department of Obstetrics and Gynaecology, Armadale Health Service, Armadale, Western Australia, Australia.
المصدر: BMJ case reports [BMJ Case Rep] 2019 Nov 07; Vol. 12 (11). Date of Electronic Publication: 2019 Nov 07.
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BMJ Pub. Group
مواضيع طبية MeSH: Lymphangioleiomyomatosis/*diagnosis , Lymphangiomyoma/*pathology , Uterine Neoplasms/*pathology , Uterus/*pathology, Aged ; Diagnosis, Differential ; Female ; Humans ; Hysterectomy ; Lung Neoplasms/pathology ; Lymphangiomyoma/surgery ; Postmenopause ; Salpingo-oophorectomy ; Uterine Neoplasms/surgery ; Uterus/surgery
مستخلص: We report a unique uterine neoplasm, favoured to represent an isolated extrapulmonary lymphangioleiomyoma with unusual pathological features, in a postmenopausal woman without tuberous sclerosis complex. The large neoplasm consisted of smooth muscle fascicles and cystic spaces lined by lymphatic cells, which were negative for the melanocytic staining that is characteristically positive in lymphangioleiomyomatosis (LAM). There are fewer than 30 cases of uterine LAM reported, none of which have demonstrated this morphology or these immunohistochemical findings. The origin of LAM cells in the more typical pulmonary LAM remains unclear; the unusual features in this case may represent a distinct pathological entity or a rare variant of typical extrapulmonary LAM, and may contribute to determining the cellular origin of these rare tumours. Conversely, this may represent a case of 'prepulmonary' LAM, providing supporting evidence for a possible gynaecological origin of these tumours in the broader affected (almost exclusively female) population.
Competing Interests: Competing interests: None declared.
(© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
References: Am J Surg Pathol. 2011 Dec;35(12):1776-85. (PMID: 22020043)
Arch Pathol Lab Med. 2003 Jul;127(7):879-82. (PMID: 12823048)
Mol Endocrinol. 2013 Sep;27(9):1403-14. (PMID: 23820898)
Am J Surg Pathol. 2018 Oct;42(10):1370-1383. (PMID: 30001237)
Anticancer Res. 2015 Jun;35(6):3353-60. (PMID: 26026095)
Semin Respir Crit Care Med. 2002 Apr;23(2):85-92. (PMID: 16088601)
Am J Surg Pathol. 2015 Aug;39(8):1015-25. (PMID: 25786086)
Arch Pathol Lab Med. 2010 Dec;134(12):1823-8. (PMID: 21128782)
Am J Respir Crit Care Med. 2001 Aug 15;164(4):669-71. (PMID: 11520735)
J Clin Pathol. 2015 Jun;68(6):418-26. (PMID: 25750268)
Hum Pathol. 2010 Jan;41(1):1-15. (PMID: 19604538)
فهرسة مساهمة: Keywords: obstetrics and gynaecology; pathology; respiratory medicine
تواريخ الأحداث: Date Created: 20191110 Date Completed: 20200326 Latest Revision: 20211108
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6855895
DOI: 10.1136/bcr-2019-231683
PMID: 31704800
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-790X
DOI:10.1136/bcr-2019-231683