دورية أكاديمية
أعرض في EDS

Detection and Cellular Tropism of Porcine Astrovirus Type 3 on Breeding Farms.

التفاصيل البيبلوغرافية
العنوان: Detection and Cellular Tropism of Porcine Astrovirus Type 3 on Breeding Farms.
المؤلفون: Rawal G; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA., Matias Ferreyra F; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA., R Macedo N; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA., K Bradner L; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA., M Harmon K; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA., Mueller A; Swine Services Unlimited, Inc., Rice, MN 56367, USA., Allison G; Walcott Veterinary Clinic, Durant St. Walcott, IA 52773, USA., C L Linhares D; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA., L Arruda B; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011-1250, USA.
المصدر: Viruses [Viruses] 2019 Nov 12; Vol. 11 (11). Date of Electronic Publication: 2019 Nov 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Viral Tropism*, Astroviridae/*physiology , Astroviridae Infections/*veterinary , Swine Diseases/*diagnosis , Swine Diseases/*virology, Animals ; Breeding ; Cross-Sectional Studies ; Farms ; In Situ Hybridization ; Molecular Diagnostic Techniques ; Swine
مستخلص: Astroviruses cause disease in a variety of species. Yet, little is known about the epidemiology of a majority of astroviruses including porcine astrovirus type 3 (PoAstV3), which is a putative cause of polioencephalomyelitis in swine. Accordingly, a cross-sectional study was conducted on sow farms with or without reported PoAstV3-associated neurologic disease in growing pigs weaned from those farms. Additionally, a conveniently selected subset of piglets from one farm was selected for gross and histologic evaluation. The distribution of PoAstV3 in the enteric system was evaluated through in situ hybridization. PoAstV3, as detected by RT-qPCR on fecal samples, was frequently detected across sows and piglets (66-90%) on all farms (65-85%). PoAstV3 was detected subsequently at a similar detection frequency (77% vs 85%) on one farm after three months. Viral shedding, as determined by the cycle quantification value, suggests that piglets shed higher quantities of virus than adult swine. No link between gastrointestinal disease and PoAstV3 was found. However, PoAstV3 was detected by in situ in myenteric plexus neurons of piglets elucidating a possible route of spread of the virus from the gastrointestinal tract to the central nervous system. These data suggest PoAstV3 has endemic potential, is shed in the feces at greater quantities by suckling piglets when compared to sows, and infection is widespread on farms in which it is detected.
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فهرسة مساهمة: Keywords: Porcine astrovirus type 3; astrovirus; detection; swine
تواريخ الأحداث: Date Created: 20191114 Date Completed: 20200916 Latest Revision: 20200916
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6893673
DOI: 10.3390/v11111051
PMID: 31718108
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v11111051