دورية أكاديمية
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease.
| العنوان: | Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease. |
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| المؤلفون: | Hertel J; School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Harms AC; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, Leiden, the Netherlands., Heinken A; School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg., Baldini F; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg., Thinnes CC; School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg., Glaab E; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg., Vasco DA; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg., Pietzner M; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Stewart ID; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Wareham NJ; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Trenkwalder C; Paracelsus-Elena-Klinik, 34128 Kassel, Germany; Department of Neurosurgery, University Medical Center Goettingen, 37075 Goettingen, Germany., Krüger R; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg; Centre Hospitalier de Luxembourg (CHL), Luxembourg, Luxembourg., Hankemeier T; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, Leiden, the Netherlands., Fleming RMT; School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Faculty of Science, Leiden University, Leiden, the Netherlands., Mollenhauer B; Paracelsus-Elena-Klinik, 34128 Kassel, Germany; Department of Neurology, University Medical Center Goettingen, 37075 Goettingen, Germany., Thiele I; School of Medicine, National University of Galway, Galway, Ireland; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Campus Belval, Esch-sur-Alzette, Luxembourg; Division of Microbiology, National University of Galway, Galway, Ireland; APC Microbiome Ireland, Ireland. Electronic address: ines.thiele@nuigalway.ie. |
| المصدر: | Cell reports [Cell Rep] 2019 Nov 12; Vol. 29 (7), pp. 1767-1777.e8. |
| نوع المنشور: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*, Parkinson Disease/*microbiology , Sulfur/*metabolism, Aged ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged |
| مستخلص: | Parkinson's disease (PD) exhibits systemic effects on the human metabolism, with emerging roles for the gut microbiome. Here, we integrate longitudinal metabolome data from 30 drug-naive, de novo PD patients and 30 matched controls with constraint-based modeling of gut microbial communities derived from an independent, drug-naive PD cohort, and prospective data from the general population. Our key results are (1) longitudinal trajectory of metabolites associated with the interconversion of methionine and cysteine via cystathionine differed between PD patients and controls; (2) dopaminergic medication showed strong lipidomic signatures; (3) taurine-conjugated bile acids correlated with the severity of motor symptoms, while low levels of sulfated taurolithocholate were associated with PD incidence in the general population; and (4) computational modeling predicted changes in sulfur metabolism, driven by A. muciniphila and B. wadsworthia, which is consistent with the changed metabolome. The multi-omics integration reveals PD-specific patterns in microbial-host sulfur co-metabolism that may contribute to PD severity. (Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.) |
| معلومات مُعتمدة: | MR/N003284/1 United Kingdom MRC_ Medical Research Council; G1000143 United Kingdom MRC_ Medical Research Council; MC_UU_12015/1 United Kingdom MRC_ Medical Research Council; 14136 United Kingdom CRUK_ Cancer Research UK; G0401527 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Parkinson's disease; bile acid metabolism; metabolic modeling; metabolism; metabolomics; metagenomics; microbiome; neurodegenerative disease; taurine metabolism; transsulfuration pathway |
| المشرفين على المادة: | 70FD1KFU70 (Sulfur) |
| تواريخ الأحداث: | Date Created: 20191114 Date Completed: 20200916 Latest Revision: 20210317 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6856723 |
| DOI: | 10.1016/j.celrep.2019.10.035 |
| PMID: | 31722195 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2019.10.035 |