دورية أكاديمية
أعرض في EDS

Human Immunodeficiency Virus Infection Is Associated With Preterm Delivery Independent of Vaginal Microbiota in Pregnant African Women.

التفاصيل البيبلوغرافية
العنوان: Human Immunodeficiency Virus Infection Is Associated With Preterm Delivery Independent of Vaginal Microbiota in Pregnant African Women.
المؤلفون: Gudza-Mugabe M; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.; National Microbiology Reference Laboratory, Harare, Zimbabwe.; Department of Medical Microbiology, University of Zimbabwe, Harare, Zimbabwe., Havyarimana E; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa., Jaumdally S; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa., Garson KL; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Lennard K; Department of Integrative Biomedical Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Tarupiwa A; National Microbiology Reference Laboratory, Harare, Zimbabwe., Mugabe F; Harare Central Hospital, Zimbabwe, Harare, Zimbabwe., Marere T; College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Mavenyengwa RT; Department of Medical Microbiology, University of Zimbabwe, Harare, Zimbabwe., Masson L; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa., Jaspan HB; Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa.; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.; Departments of Pediatrics and Global Health, University of Washington, Seattle, Washington, USA.
المصدر: The Journal of infectious diseases [J Infect Dis] 2020 Mar 16; Vol. 221 (7), pp. 1194-1203.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press
مواضيع طبية MeSH: HIV Infections/*epidemiology , Pregnancy Complications, Infectious/*epidemiology , Premature Birth/*epidemiology , Vagina/*microbiology, Adult ; Africa ; Cross-Sectional Studies ; Cytokines/analysis ; Female ; HIV Infections/complications ; Humans ; Inflammation ; Pregnancy ; Premature Birth/virology ; Risk Factors ; Vagina/metabolism
مستخلص: Background: During pregnancy, the vaginal microbiota is relatively stable. However, African women have more diverse vaginal microbiota than their European counterparts, in addition to high human immunodeficiency virus (HIV) prevalence and risk of adverse birth outcomes. Although HIV is associated with alterations in vaginal microbiota and inflammation in nonpregnant women, these relationships are underexplored in pregnant women.
Methods: In this study, we characterize the vaginal microbiota and immune factors in pregnant African women who were HIV-uninfected (n = 314) versus HIV-infected (n = 42). Mucosal samples were collected once at the enrollment visit (between 15 and 35 weeks of gestation) and women were followed until delivery.
Results: Vaginal microbial communities of pregnant women with HIV were significantly more diverse than women without HIV (P = .004), with community structure also differing by HIV status (P = .002, R2 = 0.02). Human immunodeficiency virus infection was also associated with increased risk of preterm birth (PTB) (31% versus 15.3%; P = .066). In a multivariate analysis, HIV infection was independently associated with diverse vaginal community state type (CST)-IVA (P = .005) and CST-IVB (P = .018) as well as PTB (P = .049). No association between HIV status and cytokine concentrations was found.
Conclusions: Longitudinal studies with accurate gestational age assessment would be important to confirm these relationships.
(© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.)
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معلومات مُعتمدة: R01 AI128792 United States AI NIAID NIH HHS; R01 HD083040 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: cytokines; HIV infection; premature delivery; vaginal microbiota
المشرفين على المادة: 0 (Cytokines)
تواريخ الأحداث: Date Created: 20191114 Date Completed: 20210104 Latest Revision: 20210316
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7075414
DOI: 10.1093/infdis/jiz584
PMID: 31722395
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-6613
DOI:10.1093/infdis/jiz584