دورية أكاديمية
أعرض في EDS

Prediction of kidney transplant outcome based on different DGF definitions in Chinese deceased donation.

التفاصيل البيبلوغرافية
العنوان: Prediction of kidney transplant outcome based on different DGF definitions in Chinese deceased donation.
المؤلفون: Hu XJ; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Zheng J; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Li Y; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Tian XH; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Tian PX; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Xiang HL; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Pan XM; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Ding CG; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Ding XM; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China., Xue WJ; Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. xwujun126@mail.xjtu.edu.cn.; Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China. xwujun126@mail.xjtu.edu.cn.
المصدر: BMC nephrology [BMC Nephrol] 2019 Nov 13; Vol. 20 (1), pp. 409. Date of Electronic Publication: 2019 Nov 13.
نوع المنشور: Comparative Study; Journal Article; Observational Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967793 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2369 (Electronic) Linking ISSN: 14712369 NLM ISO Abbreviation: BMC Nephrol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2000-
مواضيع طبية MeSH: Tissue Donors*, Delayed Graft Function/*diagnosis , Kidney Transplantation/*adverse effects , Postoperative Complications/*diagnosis, Adult ; Area Under Curve ; China ; Creatinine/blood ; Delayed Graft Function/epidemiology ; Female ; Glomerular Filtration Rate ; Graft Survival ; Heart Arrest ; Humans ; Immunosuppression Therapy/methods ; Immunosuppressive Agents/therapeutic use ; Incidence ; Kaplan-Meier Estimate ; Kidney/physiology ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors ; Sensitivity and Specificity ; Time Factors ; Treatment Outcome
مستخلص: Background: Delayed graft function (DGF) is an important complication of kidney transplantation and can be diagnosed according to different definitions. DGF has been suggested to be associated with the long-term outcome of kidney transplantation surgery. However, the best DGF definition for predicting renal transplant outcomes in Chinese donations after cardiac death (DCDs) remains to be determined.
Method: A total of 372 DCD kidney transplant recipients from June 2013 to July 2017 in the First Affiliated Hospital of Xi'an Jiaotong University were included in this retrospective study to compare 6 different DGF definitions. The relationships of the DGF definitions with transplant outcome were analyzed, including graft loss (GL) and death-censored graft loss (death-censored GL). Renal function indicators, including one-year estimated glomerular filtration rate (eGFR) and three-year eGFR, and were compared between different DGF groups.
Results: The incidence of DGF varied from 4.19 to 35.22% according to the different DGF diagnoses. All DGF definitions were significantly associated with three-year GL as well as death-censored GL. DGF based on requirement of hemodialysis within the first week had the best predictive value for GL (AUC 0.77), and DGF based on sCr variation during the first 3 days post-transplant had the best predictive value for three-year death-censored GL (AUC 0.79). Combination of the 48-h sCr reduction ratio and classical DGF can improve the AUC for GL (AUC 0.85) as well as the predictive accuracy for death-censored GL (83.3%).
Conclusion: DGF was an independent risk factor for poor transplant outcome. The combination of need for hemodialysis within the first week and the 48-h serum creatinine reduction rate has a better predictive value for patient and poor graft outcome.
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فهرسة مساهمة: Keywords: Definitions; Delayed graft function; Donation after cardiac death; Kidney transplant outcome
المشرفين على المادة: 0 (Immunosuppressive Agents)
AYI8EX34EU (Creatinine)
تواريخ الأحداث: Date Created: 20191115 Date Completed: 20201021 Latest Revision: 20211204
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6854725
DOI: 10.1186/s12882-019-1557-x
PMID: 31722677
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2369
DOI:10.1186/s12882-019-1557-x