دورية أكاديمية
أعرض في EDS

Methods for diagnosing bile acid malabsorption: a systematic review.

التفاصيل البيبلوغرافية
العنوان: Methods for diagnosing bile acid malabsorption: a systematic review.
المؤلفون: Lyutakov I; Clinic of Gastroenterology, University Hospital 'Tsaritsa Yoanna - ISUL', Sofia, Bulgaria., Ursini F; Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Penchev P; Clinic of Gastroenterology, University Hospital 'Tsaritsa Yoanna - ISUL', Sofia, Bulgaria., Caio G; Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Carroccio A; DiBiMIS University of Palermo, Palermo, Italy.; Internal Medicine, Giovanni Paolo II Hospital, Sciacca (ASP Agrigento), Sciacca, Italy., Volta U; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., De Giorgio R; Department of Medical Sciences, University of Ferrara, Ferrara, Italy. roberto.degiorgio@unife.it.
المصدر: BMC gastroenterology [BMC Gastroenterol] 2019 Nov 14; Vol. 19 (1), pp. 185. Date of Electronic Publication: 2019 Nov 14.
نوع المنشور: Journal Article; Systematic Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Bile Acids and Salts/*metabolism , Malabsorption Syndromes/*diagnosis , Taurocholic Acid/*analogs & derivatives, Biomarkers/analysis ; Humans ; Intestinal Reabsorption/physiology ; Malabsorption Syndromes/metabolism ; Malabsorption Syndromes/physiopathology ; Sensitivity and Specificity ; Taurocholic Acid/analysis
مستخلص: Background: Bile acid malabsorption (BAM) and bile acid-related diarrhea represent an under-recognized cause of chronic diarrhea mainly because of limited guidance on appropriate diagnostic and laboratory tests. We aimed to perform a systematic review of the literature in order to identify and compare the diagnostic accuracy of different diagnostic methods for patients with BAM, despite a proven gold standard test is still lacking.
Methods: A PubMed literature review and a manual search were carried out. Relevant full papers, evaluating the diagnostic accuracy of different methods for BAM, were assessed. Available data were analyzed to estimate the sensitivity and specificity of each published test.
Results: Overall, more than one test was considered in published papers on BAM. The search strategy retrieved 574 articles; of these, only 16 were full papers (with a total of 2.332 patients) included in the final review. Specifically, n = 8 studies used 75 Selenium-homotaurocholic-acid-test ( 75 SeHCAT) with a < 10% retention threshold; n = 8 studies evaluated fasting serum 7-α-hydroxy-4-cholesten-3-one (C4); n = 3 studies involved total fecal bile acid (BA) excretion over 48 h; n = 4 studies assessed fibroblast growth factor 19 (FGF19). 75 SeHCAT showed an average sensitivity and specificity of 87.32 and 93.2%, respectively, followed by serum C4 (85.2 and 71.1%) and total fecal BA (66.6 and 79.3%). Fasting serum FGF19 had the lowest sensitivity and specificity (63.8 and 72.3%). All the extracted data were associated with substantial heterogeneity.
Conclusions: Our systematic review indicates that 75 SeHCAT has the highest diagnostic accuracy for BAM, followed by serum C4 assay. The diagnostic yield of fecal BA and FGF19 assays is still under investigation. Our review reinforces the need for novel biomarkers aimed to an objective detection of BAM and therefore improving the management of this condition.
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فهرسة مساهمة: Keywords: Bile acid malabsorption; Biomarkers; Chronic diarrhea; Diagnostic accuracy
المشرفين على المادة: 0 (Bile Acids and Salts)
0 (Biomarkers)
5E090O0G3Z (Taurocholic Acid)
75018-70-1 (23-seleno-25-homotaurocholic acid)
تواريخ الأحداث: Date Created: 20191116 Date Completed: 20200409 Latest Revision: 20200409
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6854889
DOI: 10.1186/s12876-019-1102-1
PMID: 31726982
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-230X
DOI:10.1186/s12876-019-1102-1