دورية أكاديمية
أعرض في EDS

Self-cured resin modified by quaternary ammonium methacrylates and chlorhexidine: Cytotoxicity, antimicrobial, physical, and mechanical properties.

التفاصيل البيبلوغرافية
العنوان: Self-cured resin modified by quaternary ammonium methacrylates and chlorhexidine: Cytotoxicity, antimicrobial, physical, and mechanical properties.
المؤلفون: Campos KPL; Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University - UERJ, Rio de Janeiro, RJ, Brazil; School of Dentistry, Estácio de Sá University - UNESA, Rio de Janeiro, RJ, Brazil., Viana GM; School of Pharmacy, LabTIF, Federal University of Rio de Janeiro - UFRJ, Ilha do Fundão, Rio de Janeiro, RJ, Brazil., Cabral LM; School of Pharmacy, LabTIF, Federal University of Rio de Janeiro - UFRJ, Ilha do Fundão, Rio de Janeiro, RJ, Brazil., Portela MB; School of Dentistry, Federal Fluminense University - UFF, Niterói, RJ, Brazil., Hirata Junior R; School of Medical Sciences, Rio de Janeiro State University - UERJ, Rio de Janeiro, RJ, Brazil., Cavalcante LM; School of Dentistry, Federal Fluminense University - UFF, Niterói, RJ, Brazil; Nucleus for Dental Biomaterials Research, UVA-Veiga de Almeida University, Rio de Janeiro, RJ, Brazil., Lourenço EJV; Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University - UERJ, Rio de Janeiro, RJ, Brazil; Nucleus for Dental Biomaterials Research, UVA-Veiga de Almeida University, Rio de Janeiro, RJ, Brazil., Telles DM; Department of Prosthodontics, School of Dentistry, Rio de Janeiro State University - UERJ, Rio de Janeiro, RJ, Brazil. Electronic address: dmtelles@uerj.br.
المصدر: Dental materials : official publication of the Academy of Dental Materials [Dent Mater] 2020 Jan; Vol. 36 (1), pp. 68-75. Date of Electronic Publication: 2019 Nov 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 8508040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0097 (Electronic) Linking ISSN: 01095641 NLM ISO Abbreviation: Dent Mater
أسماء مطبوعة: Publication: 1998- : Kidlington, Oxford, UK : Elsevier Science
Original Publication: Copenhagen : Munksgaard, c1985-
مواضيع طبية MeSH: Ammonium Compounds* , Anti-Infective Agents*, Anti-Bacterial Agents ; Chlorhexidine ; Materials Testing ; Methacrylates ; Surface Properties
مستخلص: Objective: To evaluate the addition of dimethylaminohexadecyl methacrylate (DMAHDM) and chlorhexidine diacetate on cytotoxicity, antimicrobial activity, physical, and mechanical properties of a self-cured resin.
Methods: 132 disk-shaped and 48 rectangular specimens were divided into four experimental groups as described: Control Group (CG - no addition), dCHX (1%), DMAHDM (5%), and DMAHDM+dCHX (5%+1%). The biofilm viability, flexural strength (FS - ISO 20795-1:2013), surface roughness (SR), and color stability (ΔE) were analyzed after being stored for 4 weeks in distilled water and immersed for 72h in coffee. Cytotoxicity was measured after 24h, 3, and 7 days of elution using an MTT test on L929 cells (ISO 10993-5:2009). SR and ΔE were measured by a contact profilometer and a spectrophotometer using the CIELab parameter. Data were submitted to ANOVA and Bonferroni's/Tukey's tests (p≤0.05).
Results: Significant antimicrobial activity against Streptococcus mutans and Candida albicans was detected in all groups when compared to the CG (p<0.05). Only the dCHX group, in 24h of elution, demonstrated no cytotoxicity effects. There was a statistical difference for FS on the tested groups (p<0.05). No differences were detected in the initial roughness' measurements among the groups (p>0.05). However, after storage and immersion in coffee, the groups containing DMAHDM presented with rougher surfaces and significantly lower color stability compared to the control (p<0.05).
Significance: The addition of dCHX and DMAHDM in self-cured resin presented antimicrobial properties; however, cytotoxicity, physical, and mechanical properties were compromised.
(Copyright © 2019 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Biofilm inhibition; Chlorhexidine; Cytotoxicity; Mechanical properties; PMMA; Physical properties; Quaternary of ammonium methacrylate
المشرفين على المادة: 0 (Ammonium Compounds)
0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
0 (Methacrylates)
R4KO0DY52L (Chlorhexidine)
تواريخ الأحداث: Date Created: 20191119 Date Completed: 20200205 Latest Revision: 20200205
رمز التحديث: 20221213
DOI: 10.1016/j.dental.2019.10.007
PMID: 31735423
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0097
DOI:10.1016/j.dental.2019.10.007