دورية أكاديمية
Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice.
| العنوان: | Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice. |
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| المؤلفون: | Soares RDF; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Campos MGN; Institute of Science and Technology, Federal University of Alfenas, Poços de Caldas, Brazil., Ribeiro GP; Department of Food and Drugs, College of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Brazil., Salles BCC; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil.; José do Rosário Vellano University, MG, 37130-000, Brazil., Cardoso NS; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Ribeiro JR; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Souza RM; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Leme KC; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Soares CB; Institute of Science and Technology, Federal University of Alfenas, Poços de Caldas, Brazil., de Oliveira CM; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Elston LB; Pontifícia Universidade Católica de Minas Gerais, Poços de Caldas, Brazil., da Fonseca CCP; Pontifícia Universidade Católica de Minas Gerais, Poços de Caldas, Brazil., Ferreira EB; Department of Statistics, Institute of Exact Sciences, Federal University of Alfenas, Alfenas, Brazil., Rodrigues MR; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Duarte SMS; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil., Paula FBA; Department of Clinical and Toxicological Analysis, College of Pharmaceutical Sciences, Federal University of Alfenas, MG, 37130-001, Brazil. |
| المصدر: | Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2020 Mar; Vol. 108 (3), pp. 654-662. Date of Electronic Publication: 2019 Dec 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101234237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4965 (Electronic) Linking ISSN: 15493296 NLM ISO Abbreviation: J Biomed Mater Res A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, NJ : John Wiley & Sons, c2002- |
| مواضيع طبية MeSH: | Passiflora*/chemistry, Antioxidants/*administration & dosage , Chitosan/*chemistry , Flavonoids/*administration & dosage , Hydrogels/*chemistry , Wound Healing/*drug effects, Animals ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Diabetes Mellitus, Experimental/complications ; Drug Delivery Systems ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Rats, Wistar |
| مستخلص: | This study aimed to develop a chitosan-based hydrogel containing a mixture of flavonoids isolated from the leaves of Passiflora edulis Sims and to evaluate its stability, antioxidant properties, and wound healing effects on cutaneous lesions in diabetic rats. in vitro studies were carried out to evaluate the biocompatibility and flavonoid release from the chitosan hydrogel. in vivo wound healing studies were conducted on male Wistar rats, where the injured tissue was removed for histological analysis and determination of lipid peroxidation, superoxide dismutase activity, and glutathione peroxidase activity. From the histological analysis and macroscopic evaluation of the contraction of the wounds, it was observed that the formulation presented wound healing properties. In addition, treatment of the wound with the formulation stimulated the antioxidant defense system, suggesting a beneficial effect during the treatment of skin lesions in diabetic rats, especially in the first few days after wounding. According to these results, we can conclude that the chitosan hydrogel containing the flavonoid analyzed in this study has potential use as dressings in the treatment of wounds. (© 2019 Wiley Periodicals, Inc.) |
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| فهرسة مساهمة: | Keywords: Passiflora edulis; antioxidant; chitosan; flavonoid; hydrogel; wound healing |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Flavonoids) 0 (Hydrogels) 9012-76-4 (Chitosan) |
| تواريخ الأحداث: | Date Created: 20191121 Date Completed: 20210831 Latest Revision: 20210831 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/jbm.a.36845 |
| PMID: | 31747098 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1552-4965 |
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| DOI: | 10.1002/jbm.a.36845 |