دورية أكاديمية
Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice.
| العنوان: | Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice. |
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| المؤلفون: | Steadman PE; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada., Xia F; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada., Ahmed M; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada., Mocle AJ; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada., Penning ARA; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada., Geraghty AC; Department of Neurology, Stanford University, Stanford, CA 94305, USA., Steenland HW; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Max Planck Institute of Microstructure Physics, Halle 06120, Germany., Monje M; Department of Neurology, Stanford University, Stanford, CA 94305, USA., Josselyn SA; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Brain, Mind and Consciousness Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada., Frankland PW; Program in Neurosciences and Mental Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Institute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5G 1X8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3G3, Canada; Child and Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada. Electronic address: paul.frankland@sickkids.ca. |
| المصدر: | Neuron [Neuron] 2020 Jan 08; Vol. 105 (1), pp. 150-164.e6. Date of Electronic Publication: 2019 Nov 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Cell Differentiation/*physiology , Cerebral Cortex/*physiology , Hippocampus/*physiology , Memory Consolidation/*physiology , Oligodendroglia/*physiology, Animals ; Conditioning, Psychological/physiology ; Electric Stimulation ; Fear/physiology ; Female ; Male ; Maze Learning/physiology ; Mice ; Mice, Transgenic ; Myelin Sheath/physiology ; Neural Pathways/physiology ; Transcription Factors/genetics ; Transcription Factors/physiology |
| مستخلص: | The generation of myelin-forming oligodendrocytes persists throughout life and is regulated by neural activity. Here we tested whether experience-driven changes in oligodendrogenesis are important for memory consolidation. We found that water maze learning promotes oligodendrogenesis and de novo myelination in the cortex and associated white matter tracts. Preventing these learning-induced increases in oligodendrogenesis without affecting existing oligodendrocytes impaired memory consolidation of water maze, as well as contextual fear, memories. These results suggest that de novo myelination tunes activated circuits, promoting coordinated activity that is important for memory consolidation. Consistent with this, contextual fear learning increased the coupling of hippocampal sharp wave ripples and cortical spindles, and these learning-induced increases in ripple-spindle coupling were blocked when oligodendrogenesis was suppressed. Our results identify a non-neuronal form of plasticity that remodels hippocampal-cortical networks following learning and is required for memory consolidation. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Nat Rev Neurosci. 2020 Feb;21(2):57. (PMID: 31875028) Comment in: Neuron. 2020 Jan 8;105(1):9-11. (PMID: 31951529) Comment in: Nat Neurosci. 2020 Apr;23(4):469-470. (PMID: 32094969) |
| References: | Neuron. 2017 Aug 16;95(4):743-756. (PMID: 28817797) Neuron. 2017 Apr 19;94(2):363-374.e4. (PMID: 28426969) Nature. 1993 Jan 21;361(6409):258-60. (PMID: 8093806) Science. 2014 May 2;344(6183):1252304. (PMID: 24727982) Dev Neurobiol. 2018 Feb;78(2):123-135. (PMID: 28986960) J Neurosci Methods. 2010 Aug 30;191(2):191-200. (PMID: 20600317) Dev Cell. 2013 Jun 24;25(6):599-609. (PMID: 23806617) Science. 2013 Mar 15;339(6125):1290-5. (PMID: 23493706) Nature. 2003 Feb 20;421(6925):844-8. (PMID: 12594513) Science. 2017 Apr 7;356(6333):73-78. (PMID: 28386011) Science. 2014 Apr 18;344(6181):319-24. (PMID: 24744380) J Neurosci. 2006 Jul 19;26(29):7555-64. (PMID: 16855083) Nat Neurosci. 2015 May;18(5):683-9. (PMID: 25849987) Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130288. (PMID: 24298167) Science. 2014 Oct 17;346(6207):318-22. (PMID: 25324381) J Neurosci. 2018 Apr 11;38(15):3631-3642. (PMID: 29507147) Nat Neurosci. 2008 Dec;11(12):1392-401. (PMID: 18849983) Nat Neurosci. 2009 Jul;12(7):919-26. (PMID: 19483687) Neuroscience. 2014 Sep 12;276:135-47. (PMID: 24291730) Nat Rev Neurosci. 2010 Feb;11(2):114-26. (PMID: 20046194) Nat Neurosci. 2016 Sep;19(9):1210-1217. (PMID: 27455109) Elife. 2016 Jul 06;5:. (PMID: 27383052) Nat Commun. 2017 Apr 06;8:15039. (PMID: 28382952) Trends Neurosci. 2008 Jul;31(7):361-70. (PMID: 18538868) Nat Neurosci. 2016 Jul;19(7):959-64. (PMID: 27182818) Cell. 2014 Nov 6;159(4):766-74. (PMID: 25417154) Nat Neurosci. 2015 May;18(5):628-30. (PMID: 25849985) Neuron. 1998 Nov;21(5):1123-8. (PMID: 9856467) J Neurosci. 2006 Dec 13;26(50):12914-20. (PMID: 17167082) Science. 2011 Sep 16;333(6049):1647-51. (PMID: 21817014) Science. 2011 Feb 18;331(6019):924-8. (PMID: 21330548) Nat Rev Neurosci. 2015 Dec;16(12):756-67. (PMID: 26585800) Nat Rev Neurosci. 2018 Aug;19(8):485-498. (PMID: 29970909) Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9887-92. (PMID: 8790426) Cereb Cortex. 2018 Oct 1;28(10):3711-3723. (PMID: 30060138) Neuron. 2017 Dec 20;96(6):1239-1251. (PMID: 29268094) Cereb Cortex. 1996 Mar-Apr;6(2):81-92. (PMID: 8670641) Nat Neurosci. 2011 Feb;14(2):147-53. (PMID: 21270783) Neuron. 2010 Nov 18;68(4):668-81. (PMID: 21092857) Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17207-12. (PMID: 21949372) Nat Neurosci. 2012 Mar 18;15(4):528-36. (PMID: 22426254) Nat Neurosci. 2013 Jun;16(6):668-76. (PMID: 23624515) Elife. 2017 Sep 29;6:. (PMID: 28960176) Neuron. 2019 Jul 17;103(2):250-265.e8. (PMID: 31122677) Nat Neurosci. 2018 May;21(5):696-706. (PMID: 29556025) Nat Commun. 2018 Jan 22;9(1):306. (PMID: 29358753) Science. 2016 May 13;352(6287):812-6. (PMID: 27174984) Nat Neurosci. 2009 Nov;12(11):1370-1. (PMID: 19820707) Proc Natl Acad Sci U S A. 2011 May 17;108(20):8456-60. (PMID: 21531906) PLoS One. 2011;6(6):e20678. (PMID: 21701690) Neurosci Res. 2014 Jul;84:27-33. (PMID: 24642278) Cell. 2009 Jul 10;138(1):172-85. (PMID: 19596243) Nat Rev Neurosci. 2015 Sep;16(9):521-34. (PMID: 26289572) Nat Neurosci. 2018 May;21(5):683-695. (PMID: 29556031) Brain Res. 2004 May 22;1008(2):261-72. (PMID: 15145764) |
| معلومات مُعتمدة: | R01 MH119421 United States MH NIMH NIH HHS; MOP74650 Canada CIHR; PJT156164 Canada CIHR; FDN143227 Canada CIHR |
| فهرسة مساهمة: | Keywords: Mrf; Oligodendrogenesis; cortex; hippocampus; memory consolidation; myelin |
| المشرفين على المادة: | 0 (Transcription Factors) 0 (myelin gene regulatory factor, mouse) |
| تواريخ الأحداث: | Date Created: 20191123 Date Completed: 20200330 Latest Revision: 20201023 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7579726 |
| DOI: | 10.1016/j.neuron.2019.10.013 |
| PMID: | 31753579 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1097-4199 |
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| DOI: | 10.1016/j.neuron.2019.10.013 |