دورية أكاديمية
أعرض في EDS

TLR2 and NODs1 and 2 cooperate in inflammatory responses associated with renal ischemia reperfusion injury.

التفاصيل البيبلوغرافية
العنوان: TLR2 and NODs1 and 2 cooperate in inflammatory responses associated with renal ischemia reperfusion injury.
المؤلفون: Kasimsetty SG; Department of Immunology and Microbial Sciences, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America., Hawkes A; Department of Immunology and Microbial Sciences, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America; Scripps Clinic and Green Hospital, Division of Transplantation, 10660 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America., Barekatain K; University of California San Diego, Department of Medicine, Division of Nephrology and Hypertension, 9500 Gilman Drive, La Jolla, CA 92093, United States of America., Soo E; Department of Immunology and Microbial Sciences, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America; Scripps Clinic and Green Hospital, Division of Transplantation, 10660 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America., Welch AK; Department of Immunology and Microbial Sciences, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America; University of California San Diego, Department of Medicine, Division of Nephrology and Hypertension, 9500 Gilman Drive, La Jolla, CA 92093, United States of America., McKay DB; Department of Immunology and Microbial Sciences, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America; Scripps Clinic and Green Hospital, Division of Transplantation, 10660 N. Torrey Pines Rd, La Jolla, CA 92037, United States of America. Electronic address: dmckay@scripps.edu.
المصدر: Transplant immunology [Transpl Immunol] 2020 Feb; Vol. 58, pp. 101260. Date of Electronic Publication: 2019 Nov 22.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9309923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5492 (Electronic) Linking ISSN: 09663274 NLM ISO Abbreviation: Transpl Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam : Elsevier
Original Publication: Dunton Green, Sevenoaks, Kent, UK : Edward Arnold, c1993-
مواضيع طبية MeSH: Inflammation/*metabolism , Kidney/*immunology , Myeloid Cells/*immunology , Nod1 Signaling Adaptor Protein/*metabolism , Nod2 Signaling Adaptor Protein/*metabolism , Reperfusion Injury/*metabolism , Toll-Like Receptor 2/*metabolism, Animals ; Humans ; Immunity, Innate ; Kidney/surgery ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Nod1 Signaling Adaptor Protein/genetics ; Nod2 Signaling Adaptor Protein/genetics ; Signal Transduction ; Toll-Like Receptor 2/genetics
مستخلص: Pattern recognition receptors (PRRs) are potent triggers of tissue injury following renal ischemia/reperfusion injury (IRI). Specific PRRs, such as the toll-like receptor 2 (TLR2) and the nucleotide-binding oligomerization domain-like receptors (NLRs) NOD1 and NOD2 are promising targets to abrogate inflammatory injury associated with renal IRI. Several recent reports have shown there is crosstalk between TLRs and NODs, which might boost inflammatory responses to tissue injury. This study examined the relative roles of TLR2 and NODs 1 and 2 in activation of myeloid cells that contribute to inflammation after renal IRI. We found that TLR2 and NOD1 and 2 signaling induces neutrophil, macrophage and dendritic cell migration in vitro, however their blockade only decreases neutrophil infiltration into ischemic kidneys. The results of this study suggest that future therapies targeted to innate immune blockade should consider that either TLR2 or NOD1/2 blockade could decrease neutrophil inflammation following an ischemic insult to the kidney, however blockade of these PRRs would not likely impact infiltration of dendritic cells or macrophages. Developing rational approaches that target innate immunity in IRI-induced acute kidney injury requires an understanding of the relative role of PRRs in directing inflammation in the kidney.
(Copyright © 2019. Published by Elsevier B.V.)
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معلومات مُعتمدة: R01 DK091136 United States DK NIDDK NIH HHS; R01 DK113162 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Acute kidney injury; Ischemia/reperfusion injury; NOD1; NOD2; TLR2
المشرفين على المادة: 0 (Nod1 Signaling Adaptor Protein)
0 (Nod1 protein, mouse)
0 (Nod2 Signaling Adaptor Protein)
0 (Nod2 protein, mouse)
0 (TLR2 protein, human)
0 (Toll-Like Receptor 2)
تواريخ الأحداث: Date Created: 20191125 Date Completed: 20210331 Latest Revision: 20231113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7041897
DOI: 10.1016/j.trim.2019.101260
PMID: 31760144
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5492
DOI:10.1016/j.trim.2019.101260