دورية أكاديمية
أعرض في EDS

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status.

التفاصيل البيبلوغرافية
العنوان: Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status.
المؤلفون: Peleli M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Ferreira DMS; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Tarnawski L; Department of Medicine, Centre for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., McCann Haworth S; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Xuechen L; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Zhuge Z; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Newton PT; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Massart J; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, 17177, Stockholm, Sweden., Chagin AS; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Institute for Regenerative Medicine, Sechenov University, Moscow, Russia., Olofsson PS; Department of Medicine, Centre for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Ruas JL; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Weitzberg E; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Lundberg JO; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Carlström M; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address: mattias.carlstrom@ki.se.
المصدر: Redox biology [Redox Biol] 2020 Jan; Vol. 28, pp. 101387. Date of Electronic Publication: 2019 Nov 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam]: Elsevier, B.V., [2013]-
مواضيع طبية MeSH: Diet, High-Fat/*adverse effects , Mitochondria/*metabolism , Nitrates/*administration & dosage , Obesity/*diet therapy, Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/metabolism ; Animals ; Blood Glucose/drug effects ; Cell Respiration/drug effects ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Male ; Membrane Transport Proteins/metabolism ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Nitrates/pharmacology ; Obesity/chemically induced ; Obesity/metabolism ; Palmitic Acid/adverse effects ; Random Allocation ; Uncoupling Protein 1/metabolism ; Up-Regulation
مستخلص: Emerging evidence indicates that dietary nitrate can reverse several features of the metabolic syndrome, but the underlying molecular mechanisms still remain elusive. The aim of the present study was to explore mechanisms involved in the effects of dietary nitrate on the metabolic dysfunctions induced by high-fat diet (HFD) in mice. Four weeks old C57BL/6 male mice, exposed to HFD for ten weeks, were characterised by increased body weight, fat content, increased fasting glucose and impaired glucose clearance. All these metabolic abnormalities were significantly attenuated by dietary nitrate. Mechanistically, subcutaneous primary mouse adipocytes exposed to palmitate (PA) and treated with nitrite exhibited higher mitochondrial respiration, increased protein expression of total mitochondrial complexes and elevated gene expression of the thermogenesis gene UCP-1, as well as of the creatine transporter SLC6A8. Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages. In conclusion, dietary nitrate may have therapeutic utility against obesity and associated metabolic complications possibly by increasing adipocyte mitochondrial respiration and by dampening inflammation and oxidative stress.
(Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: Inflammation; Inorganic nitrate; Metabolic syndrome; Mitochondria; Thermogenesis; Visceral fat
المشرفين على المادة: 0 (Blood Glucose)
0 (Membrane Transport Proteins)
0 (Nitrates)
0 (Ucp1 protein, mouse)
0 (Uncoupling Protein 1)
0 (creatine transporter)
2V16EO95H1 (Palmitic Acid)
تواريخ الأحداث: Date Created: 20191126 Date Completed: 20200930 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6883295
DOI: 10.1016/j.redox.2019.101387
PMID: 31765889
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-2317
DOI:10.1016/j.redox.2019.101387