دورية أكاديمية
أعرض في EDS

Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens.

التفاصيل البيبلوغرافية
العنوان: Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens.
المؤلفون: Boyce GR; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Gluck-Thaler E; Department of Plant Pathology, The Ohio State University, Columbus, OH, 43210, USA., Slot JC; Department of Plant Pathology, The Ohio State University, Columbus, OH, 43210, USA., Stajich JE; Department of Microbiology and Plant Pathology and Institute for Integrative Genome Biology, University of California, Riverside, CA, 92521, USA., Davis WJ; Department of Ecology and Evolution, University of Michigan, Ann Arbor, MI, 48109, USA., James TY; Department of Ecology and Evolution, University of Michigan, Ann Arbor, MI, 48109, USA., Cooley JR; Department of Ecology and Evolutionary Biology, University of Connecticut, Hartford, CT, 06103, USA., Panaccione DG; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Eilenberg J; Department of Plant and Environmental Science, University of Copenhagen, Denmark., De Fine Licht HH; Department of Plant and Environmental Science, University of Copenhagen, Denmark., Macias AM; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Berger MC; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Wickert KL; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Stauder CM; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Spahr EJ; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Maust MD; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Metheny AM; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Simon C; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, Connecticut, 06269, USA., Kritsky G; Department of Biology, Mount St. Joseph University, Cincinnati, OH, 45233, USA., Hodge KT; Plant Pathology & Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA., Humber RA; Plant Pathology & Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA.; USDA-ARS-NAA-BioIPM, Ithaca, NY, 14853, USA., Gullion T; Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA., Short DPG; Amycel Spawnmate, Royal Oaks, California, 95067, USA., Kijimoto T; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA., Mozgai D; Cicadamania.com, Sea Bright, New Jersey, 07760, USA., Arguedas N; Cleveland Metroparks, Cleveland, OH, USA., Kasson MT; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
المصدر: Fungal ecology [Fungal Ecol] 2019 Oct; Vol. 41, pp. 147-164. Date of Electronic Publication: 2019 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101496718 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1754-5048 (Print) Linking ISSN: 18780083 NLM ISO Abbreviation: Fungal Ecol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Elsevier
مستخلص: Entomopathogenic fungi routinely kill their hosts before releasing infectious spores, but a few species keep insects alive while sporulating, which enhances dispersal. Transcriptomics- and metabolomics-based studies of entomopathogens with post-mortem dissemination from their parasitized hosts have unraveled infection processes and host responses. However, the mechanisms underlying active spore transmission by Entomophthoralean fungi in living insects remain elusive. Here we report the discovery, through metabolomics, of the plant-associated amphetamine, cathinone, in four Massospora cicadina -infected periodical cicada populations, and the mushroom-associated tryptamine, psilocybin, in annual cicadas infected with Massospora platypediae or Massospora levispora , which likely represent a single fungal species. The absence of some fungal enzymes necessary for cathinone and psilocybin biosynthesis along with the inability to detect intermediate metabolites or gene orthologs are consistent with possibly novel biosynthesis pathways in Massospora . The neurogenic activities of these compounds suggest the extended phenotype of Massospora that modifies cicada behavior to maximize dissemination is chemically-induced.
Competing Interests: Conflicts of interest Authors declare no competing interests.
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معلومات مُعتمدة: R15 GM114774 United States GM NIGMS NIH HHS; R21 AI105167 United States AI NIAID NIH HHS; S10 OD016290 United States OD NIH HHS
فهرسة مساهمة: Keywords: Amphetamine; Cathinone; Entomopathogen; Entomophthorales; Invertebrate pathology; Magicicada; Massospora; Okanagana; Platypedia; Psilocin; Psilocybin; Tryptamine; Zoopagomycota
تواريخ الأحداث: Date Created: 20191127 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6876628
DOI: 10.1016/j.funeco.2019.06.002
PMID: 31768192
قاعدة البيانات: MEDLINE
الوصف
تدمد:1754-5048
DOI:10.1016/j.funeco.2019.06.002