دورية أكاديمية
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Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid-CB1-R Signaling.

التفاصيل البيبلوغرافية
العنوان: Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid-CB1-R Signaling.
المؤلفون: Paloczi J; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland., Matyas C; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland., Cinar R; Laboratory of Physiological Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland., Varga ZV; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland., Hasko G; Department of Anesthesiology, Columbia University, New York, New York., Schindler TH; Division of Nuclear Medicine, Washington University in St. Louis, St. Louis, Missouri., Kunos G; Laboratory of Physiological Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland., Pacher P; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2019 Sep 23; Vol. 4 (5), pp. 625-637. Date of Electronic Publication: 2019 Sep 23 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: Excessive binge alcohol drinking may adversely affect cardiovascular function. In this study we characterize the detailed hemodynamic effects of an acute alcohol binge in mice using multiple approaches and investigate the role of the endocannabinoid-cannabinoid 1 receptor (CB1-R) signaling in these effects. Acute alcohol binge was associated with elevated levels of cardiac endocannabinoid anandamide and profound cardiovascular dysfunction lasting for several hours and redistribution of circulation. These changes were attenuated by CB1-R antagonist or in CB1-R knockout mice. Our results suggest that a single alcohol binge has profound effects on the cardiovascular system, which involve endocannabinoid-CB1-R signaling.
التعليقات: Comment in: JACC Basic Transl Sci. 2019 Sep 23;4(5):638-639. (PMID: 31769444)
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فهرسة مساهمة: Keywords: 2-AG, 2-arachidonyl glycerol; AEA, anandamide; CB1-R (CB1), cannabinoid 1 receptor; CB2-R (CB2), cannabinoid 2 receptor; EF, ejection fraction; LV, left ventricle; MAP, mean arterial pressure; P-V, pressure-volume; PRSW, preload recruitable stroke work; TPR, total peripheral resistance; binge alcohol drinking; cannabinoids; contractility; dP/dtmax, maximal slope of pressure increment; endocannabinoids
تواريخ الأحداث: Date Created: 20191127 Latest Revision: 20201001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6872859
DOI: 10.1016/j.jacbts.2019.05.007
PMID: 31768478
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2019.05.007