دورية أكاديمية
Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation.
العنوان: | Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation. |
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المؤلفون: | Soma O; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Hatakeyama S; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan. shingoh@hirosaki-u.ac.jp., Yoneyama T; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Saito M; Department of Urology, Akita University Graduate School of Medicine, Akita, Japan., Sasaki H; Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan., Tobisawa Y; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Noro D; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Suzuki Y; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Tanaka M; Frontier Research Centre for Advanced Material and Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Nishimura SI; Frontier Research Centre for Advanced Material and Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Harada H; Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan., Ishida H; Department of Urology, Tokyo Woman's Medical University, Tokyo, Japan., Tanabe K; Department of Urology, Tokyo Woman's Medical University, Tokyo, Japan., Satoh S; Department of Urology, Akita University Graduate School of Medicine, Akita, Japan., Ohyama C; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. |
المصدر: | Clinical and experimental nephrology [Clin Exp Nephrol] 2020 Feb; Vol. 24 (2), pp. 174-184. Date of Electronic Publication: 2019 Nov 25. |
نوع المنشور: | Journal Article; Multicenter Study |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Japan NLM ID: 9709923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7799 (Electronic) Linking ISSN: 13421751 NLM ISO Abbreviation: Clin Exp Nephrol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2008- : Tokyo : Springer Original Publication: Tokyo : Published for the Japanese Society of Nephrology by Churchill Livingstone, c1997- |
مواضيع طبية MeSH: | Living Donors*, Graft Rejection/*blood , Kidney Transplantation/*adverse effects , Polysaccharides/*blood, Adult ; Biomarkers/blood ; Female ; Graft Rejection/etiology ; Graft Rejection/pathology ; Humans ; Japan ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome |
مستخلص: | Background: To evaluate whether serum N-glycan profile can be used as a diagnostic marker of graft rejection after living-donor kidney transplants (KT). Methods: We retrospectively examined 174 KT recipients at five medical centers. N-Glycan levels were analyzed in postoperative serum samples using glycoblotting combined with mass spectrometry. We developed an integrated score to predict graft rejection based on a combination of age, gender, immunological risk factors, and serum N-glycan levels at post-KT day D1 and D7. Rejection-free survival rates stratified by the sum of integrated scores (D1 + D7) were evaluated using Kaplan-Meier curves. Results: Of 174, 52 showed graft rejection (Rejection-pos. group) and 122 recipients did not show graft rejection (Rejection-neg. group). The integrated scores were significantly higher in the Rejection-pos. group than those of the Rejection-neg. group. Area-under-curve (AUC) value of integrated scores at post-KT D1, and D7 were 0.84 and 0.84, respectively. The sum of integrated scores (D1 + D7) ≥ 0.50 identified graft rejection with 81% sensitivity and 80% specificity; with an AUC value of 0.87. Recipients with higher sum of integrated scores (D1 + D7 ≥ 0.5) had significantly shorter rejection-free survival than those with lower scores. Conclusion: Evaluation of serum N-glycosylation profiles can identify recipients who are prone to rejection. |
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معلومات مُعتمدة: | 15H02563 and 19H05556 Japan Society for the Promotion of Science; 17K11119 Japan Society for the Promotion of Science |
فهرسة مساهمة: | Keywords: Acute rejection; Biomarkers; Glycobiology; Kidney transplantation; N-Glycan |
المشرفين على المادة: | 0 (Biomarkers) 0 (Polysaccharides) |
تواريخ الأحداث: | Date Created: 20191127 Date Completed: 20201124 Latest Revision: 20201124 |
رمز التحديث: | 20240628 |
DOI: | 10.1007/s10157-019-01820-8 |
PMID: | 31768865 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1437-7799 |
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DOI: | 10.1007/s10157-019-01820-8 |