دورية أكاديمية
أعرض في EDS

Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation.

التفاصيل البيبلوغرافية
العنوان: Serum N-glycan profiling can predict biopsy-proven graft rejection after living kidney transplantation.
المؤلفون: Soma O; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Hatakeyama S; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan. shingoh@hirosaki-u.ac.jp., Yoneyama T; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Saito M; Department of Urology, Akita University Graduate School of Medicine, Akita, Japan., Sasaki H; Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan., Tobisawa Y; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Noro D; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Suzuki Y; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan., Tanaka M; Frontier Research Centre for Advanced Material and Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Nishimura SI; Frontier Research Centre for Advanced Material and Life Science, Graduate School of Life Science, Hokkaido University, Sapporo, Japan., Harada H; Department of Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan., Ishida H; Department of Urology, Tokyo Woman's Medical University, Tokyo, Japan., Tanabe K; Department of Urology, Tokyo Woman's Medical University, Tokyo, Japan., Satoh S; Department of Urology, Akita University Graduate School of Medicine, Akita, Japan., Ohyama C; Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.; Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
المصدر: Clinical and experimental nephrology [Clin Exp Nephrol] 2020 Feb; Vol. 24 (2), pp. 174-184. Date of Electronic Publication: 2019 Nov 25.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Japan NLM ID: 9709923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7799 (Electronic) Linking ISSN: 13421751 NLM ISO Abbreviation: Clin Exp Nephrol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2008- : Tokyo : Springer
Original Publication: Tokyo : Published for the Japanese Society of Nephrology by Churchill Livingstone, c1997-
مواضيع طبية MeSH: Living Donors*, Graft Rejection/*blood , Kidney Transplantation/*adverse effects , Polysaccharides/*blood, Adult ; Biomarkers/blood ; Female ; Graft Rejection/etiology ; Graft Rejection/pathology ; Humans ; Japan ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
مستخلص: Background: To evaluate whether serum N-glycan profile can be used as a diagnostic marker of graft rejection after living-donor kidney transplants (KT).
Methods: We retrospectively examined 174 KT recipients at five medical centers. N-Glycan levels were analyzed in postoperative serum samples using glycoblotting combined with mass spectrometry. We developed an integrated score to predict graft rejection based on a combination of age, gender, immunological risk factors, and serum N-glycan levels at post-KT day D1 and D7. Rejection-free survival rates stratified by the sum of integrated scores (D1 + D7) were evaluated using Kaplan-Meier curves.
Results: Of 174, 52 showed graft rejection (Rejection-pos. group) and 122 recipients did not show graft rejection (Rejection-neg. group). The integrated scores were significantly higher in the Rejection-pos. group than those of the Rejection-neg. group. Area-under-curve (AUC) value of integrated scores at post-KT D1, and D7 were 0.84 and 0.84, respectively. The sum of integrated scores (D1 + D7) ≥ 0.50 identified graft rejection with 81% sensitivity and 80% specificity; with an AUC value of 0.87. Recipients with higher sum of integrated scores (D1 + D7 ≥ 0.5) had significantly shorter rejection-free survival than those with lower scores.
Conclusion: Evaluation of serum N-glycosylation profiles can identify recipients who are prone to rejection.
References: Int J Urol. 2019 Feb;26(2):247-252. (PMID: 30460731)
J Clin Invest. 2015 Nov 2;125(11):4160-70. (PMID: 26436649)
Int J Urol. 2019 Dec;26(12):1128-1137. (PMID: 31587389)
Int J Mol Sci. 2017 Dec 06;18(12):null. (PMID: 29210993)
EMBO J. 1999 Mar 15;18(6):1516-25. (PMID: 10075923)
Int J Urol. 2018 Feb;25(2):141-145. (PMID: 29068092)
ScientificWorldJournal. 2013 Dec 23;2013:268407. (PMID: 24453820)
Biochem Biophys Res Commun. 2014 Jun 13;448(4):390-6. (PMID: 24814705)
J Urol. 2014 Mar;191(3):805-13. (PMID: 24140550)
Int J Mol Sci. 2017 Feb 22;18(2):. (PMID: 28241428)
Clin Exp Nephrol. 2019 Jun;23(6):807-813. (PMID: 30809748)
Int J Urol. 2018 May;25(5):450-455. (PMID: 29444550)
Int J Mol Sci. 2017 Aug 08;18(8):null. (PMID: 28786963)
Int J Urol. 2018 Feb;25(2):112-120. (PMID: 29105189)
Cancer Med. 2017 Apr;6(4):739-748. (PMID: 28317343)
J Clin Invest. 2013 Sep;123(9):3788-96. (PMID: 23979161)
Hum Immunol. 2016 Nov;77(11):1076-1083. (PMID: 26546874)
Int J Urol. 2019 Apr;26(4):499-505. (PMID: 30818421)
Int J Urol. 2019 Dec;26(12):1114-1120. (PMID: 31522467)
Int J Urol. 2019 Feb;26(2):309-311. (PMID: 30430663)
Clin Kidney J. 2017 Feb;10(1):106-115. (PMID: 28643819)
Mol Cell Proteomics. 2010 Mar;9(3):523-37. (PMID: 20008832)
Am J Transplant. 2016 May;16(5):1352-7. (PMID: 26696524)
Prostate. 2014 Nov;74(15):1521-9. (PMID: 25154914)
Trends Mol Med. 2012 Apr;18(4):224-32. (PMID: 22425488)
Int J Urol. 2017 Dec;24(12):833-840. (PMID: 28913939)
Int J Urol. 2020 Jan;27(1):30-38. (PMID: 31522462)
Transplant Proc. 2014;46(2):445-8. (PMID: 24655984)
Am J Nephrol. 2017;46(3):187-194. (PMID: 28848141)
Glycoconj J. 1995 Jun;12(3):227-33. (PMID: 7496136)
Eur Urol Focus. 2018 Apr;4(3):405-411. (PMID: 28753809)
EMBO J. 2011 Jun 28;30(15):3173-85. (PMID: 21712812)
معلومات مُعتمدة: 15H02563 and 19H05556 Japan Society for the Promotion of Science; 17K11119 Japan Society for the Promotion of Science
فهرسة مساهمة: Keywords: Acute rejection; Biomarkers; Glycobiology; Kidney transplantation; N-Glycan
المشرفين على المادة: 0 (Biomarkers)
0 (Polysaccharides)
تواريخ الأحداث: Date Created: 20191127 Date Completed: 20201124 Latest Revision: 20201124
رمز التحديث: 20240628
DOI: 10.1007/s10157-019-01820-8
PMID: 31768865
قاعدة البيانات: MEDLINE
الوصف
تدمد:1437-7799
DOI:10.1007/s10157-019-01820-8