دورية أكاديمية
أعرض في EDS

Typical epidemiology of respiratory virus infections in a Brazilian slum.

التفاصيل البيبلوغرافية
العنوان: Typical epidemiology of respiratory virus infections in a Brazilian slum.
المؤلفون: Góes LGB; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; Laboratório de Virologia Clínica e Molecular, Departamento de Microbiologia - ICB-II, Universidade de São Paulo, São Paulo, Brazil., Zerbinati RM; Institute of Virology, University of Bonn Medical Center, Bonn, Germany., Tateno AF; Institute of Virology, University of Bonn Medical Center, Bonn, Germany., de Souza AV; Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, São Paulo, Brazil., Ebach F; Institute of Virology, University of Bonn Medical Center, Bonn, Germany., Corman VM; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Infection Research (DZIF), associated partner site Charité, Berlin, Germany., Moreira-Filho CA; Departmento de Pediatria, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Durigon EL; Laboratório de Virologia Clínica e Molecular, Departamento de Microbiologia - ICB-II, Universidade de São Paulo, São Paulo, Brazil., da Silva Filho LVRF; Instituto de Ensino e Pesquisa, Hospital Israelita Albert Einstein, São Paulo, Brazil.; Instituto da Criança, Hospital das Clínicas da FMUSP, São Paulo, Brazil., Drexler JF; Institute of Virology, Charité-Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Infection Research (DZIF), associated partner site Charité, Berlin, Germany.; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov University, Moscow, Russia.
المصدر: Journal of medical virology [J Med Virol] 2020 Aug; Vol. 92 (8), pp. 1316-1321. Date of Electronic Publication: 2019 Dec 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: Coinfection/*epidemiology , Respiratory Tract Infections/*epidemiology , Respiratory Tract Infections/*transmission , Virus Diseases/*epidemiology , Virus Diseases/*transmission, Brazil/epidemiology ; Child ; Child, Preschool ; Coronavirus/genetics ; Coronavirus/isolation & purification ; Humans ; Infant ; Orthomyxoviridae/genetics ; Orthomyxoviridae/isolation & purification ; Population Density ; Poverty Areas ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus, Human/isolation & purification ; Respiratory Tract Infections/virology ; Reverse Transcriptase Polymerase Chain Reaction ; Rhinovirus/genetics ; Rhinovirus/isolation & purification ; Virus Diseases/virology
مستخلص: Host population size, density, immune status, age structure, and contact rates are critical elements of virus epidemiology. Slum populations stand out from other settings and may present differences in the epidemiology of acute viral infections. We collected nasopharyngeal specimens from 282 children aged ≤5 years with acute respiratory tract infection (ARI) during 2005 to 2006 in one of the largest Brazilian slums. We conducted real-time reverse transcription-polymerase chain reaction (RT-PCR) for 16 respiratory viruses, nested RT-PCR-based typing of rhinoviruses (HRVs), and collected clinical symptoms. Viruses were common causes of respiratory disease; with ≥1 virus being detected in 65.2% of patients. We detected 15 different viruses during 1 year with a predominance of HRV (33.0%) and human respiratory syncytial virus (hRSV, 12.1%) infections, and a high rate of viral coinfections (28.3%). We observed seasonality of hRSV, HRV and human coronavirus infections, more severe symptoms in hRSV and influenza virus (FLU) infections and prolonged circulation of seven HRV clusters likely representing distinct serotypes according to genomic sequence distances. Potentially unusual findings included the absence of human metapneumovirus detections and lack of typical FLU seasonal patterns, which may be linked to the population size and density of the slum. Nonetheless, most epidemiological patterns were similar to other studies globally, suggesting surprising similarities of virus-associated ARI across highly diverse settings and a complex impact of population characteristics on respiratory virus epidemiology.
(© 2019 The Authors. Journal of Medical Virology published by Wiley Periodicals, Inc.)
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معلومات مُعتمدة: 02/08460-6 International Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); 734548 International European Union's Horizon 2020 program through the ZIKAlliance project
فهرسة مساهمة: Keywords: Brazil; acute respiratory infection; epidemiology; real-time polymerase chain reaction; respiratory tract infections; slum; viruses
تواريخ الأحداث: Date Created: 20191127 Date Completed: 20200915 Latest Revision: 20200915
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7228228
DOI: 10.1002/jmv.25636
PMID: 31769524
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-9071
DOI:10.1002/jmv.25636