دورية أكاديمية
أعرض في EDS

Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans.

التفاصيل البيبلوغرافية
العنوان: Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans.
المؤلفون: Bergandi L; Department of Oncology, University of Torino, Torino, Italy., Skorokhod OA; Department of Oncology, University of Torino, Torino, Italy.; Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy., La Grotta R; Department of Oncology, University of Torino, Torino, Italy., Schwarzer E; Department of Oncology, University of Torino, Torino, Italy., Nuzzi R; Eye Clinic Section, Department of Surgical Sciences, University of Torino, Torino, Italy.
المصدر: Journal of ophthalmology [J Ophthalmol] 2019 Oct 30; Vol. 2019, pp. 7231015. Date of Electronic Publication: 2019 Oct 30 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 101524199 Publication Model: eCollection Cited Medium: Print ISSN: 2090-004X (Print) Linking ISSN: 2090004X NLM ISO Abbreviation: J Ophthalmol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Publishing Corporation
مستخلص: The aim of this study was to assess the oxidative stress status in eyes affected by synchysis scintillans and to compare it to vitreoretinal disorders without synchysis scintillans. Human aqueous and vitreous humors were obtained during vitrectomy from thirty-seven otherwise healthy patients that were randomly chosen among patients that had to undergo a 25-gauge pars plana vitrectomy from the central vitreous cavity, for either synchysis scintillans ( n  = 16) or vitreoretinal disorders without synchysis scintillans ( n  = 21), such as idiopathic epimacular membrane ( n  = 12), macular hole ( n  = 5), or rhegmatogenous retinal detachment ( n  = 4). The redox parameters thiobarbituric acid reactive substances (TBARS), a measurement of lipid peroxidation, nitrite concentration, an estimate of nitric oxide (NO) production, 4-hydroxynonenal (4-HNE)-protein conjugates, a structural protein modification by lipid peroxidation product 4-HNE, and the antioxidative activities of Cu,Zn-superoxide dismutase (SOD), and catalase were measured in aqueous and vitreous humors and compared between synchysis scintillans affected and not-affected patients. TBARS and nitrite levels of the vitreous humor were significantly higher in patients with synchysis scintillans as compared to patients affected by vitreoretinal disorders without synchysis scintillans. Synchysis scintillans patients had significantly lower activities of SOD and catalase both in aqueous and vitreous humors than patients with vitreoretinal disorders without synchysis. The consequently higher lipoperoxide-dependent 4-HNE production in synchysis scintillans was detectable in aqueous and vitreous humors as a significant increased accumulation of 4-HNE-protein conjugates vs nonsynchysis vitreoretinal disorders. Additionally, hyaluronic acid (HA) was significantly decreased in the vitreous body of synchysis scintillans patients. The data consistently show that synchisis scintillans is accompanied by a redox imbalance with increased oxidative modifications of 4-HNE proteins and loss of HA, both of likely importance for remote damages of the retina. It remains to be proven whether a therapeutic strategy which targets oxidative stress may be effective in the treatment of synchysis patients.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2019 Loredana Bergandi et al.)
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تواريخ الأحداث: Date Created: 20191130 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6875268
DOI: 10.1155/2019/7231015
PMID: 31781380
قاعدة البيانات: MEDLINE
الوصف
تدمد:2090-004X
DOI:10.1155/2019/7231015