دورية أكاديمية
أعرض في EDS

Local Biological Reactions and Pseudotumor-Like Tissue Formation in relation to Metal Wear in a Murine In Vivo Model.

التفاصيل البيبلوغرافية
العنوان: Local Biological Reactions and Pseudotumor-Like Tissue Formation in relation to Metal Wear in a Murine In Vivo Model.
المؤلفون: Paulus AC; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany., Ebinger K; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany., Cheng X; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany., Haßelt S; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany., Weber P; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany., Kretzer JP; Laboratory of Biomechanics and Implant Research, Clinic for Orthopedics and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany., Bader R; Biomechanics and Implant Technology Research Laboratory (FORBIOMIT), Department of Orthopaedics, University Medicine Rostock, Doberaner Straße 142, 18057 Rostock, Germany., Utzschneider S; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Ludwig-Maximilians-University, Campus Großhadern, Marchioninistraße 15, 81377 Munich, Germany.
المصدر: BioMed research international [Biomed Res Int] 2019 Oct 29; Vol. 2019, pp. 3649838. Date of Electronic Publication: 2019 Oct 29 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Arthroplasty, Replacement, Hip/*adverse effects , Chromium Alloys/*adverse effects , Hip Prosthesis/*adverse effects , Metals/*adverse effects, Animals ; Chromium Alloys/pharmacology ; Corrosion ; Disease Models, Animal ; Humans ; Inflammation/blood ; Inflammation/chemically induced ; Knee Joint/surgery ; Metals/therapeutic use ; Mice ; Polyethylene/pharmacology ; Prosthesis Failure/adverse effects ; Reoperation ; Synovial Fluid/drug effects
مستخلص: Metal wear debris and released ions (CoCrMo), which are widely generated in metal-on-metal bearings of hip implants, are also found in patients with metal-on-polyethylene bearings due to the mechanically assisted crevice corrosion of modular taper junctions, including head-neck and neck-stem taper interfaces. The resulting adverse reactions to metal debris and metal ions frequently lead to early arthroplasty revision surgery. National guidelines have since been published where the blood metal ion concentration of patients must consistently be monitored after joint replacement to prevent serious complications from developing after surgery. However, to date, the effect of metal particles and metal ions on local biological reactions is complex and still not understood in detail; the present study sought to elucidate the complex mechanism of metal wear-associated inflammation reactions. The knee joints in 4 groups each consisting of 10 female BALB/c mice received injections with cobalt chrome ions, cobalt chrome particles, and ultra-high-molecular-weight polyethylene (UHMWPE) particles or PBS (control). Seven days after injection, the synovial microcirculation and knee joint diameter were assessed via intravital fluorescence microscopy followed by histological evaluation of the synovial layer. Enlarged knee diameter, enhanced leukocyte to endothelial cell interactions, and an increase in functional capillary density within cobalt chrome particle-treated animals were significantly greater than those in the other treatment groups. Subsequently, pseudotumor-like tissue formations were observed only in the synovial tissue layer of the cobalt chrome particle-treated animals. Therefore, these findings strongly suggest that the cobalt chrome particles and not metal ions are the cause for in vivo postsurgery implantation inflammation.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2019 Alexander C. Paulus et al.)
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المشرفين على المادة: 0 (Chromium Alloys)
0 (Metals)
9002-88-4 (Polyethylene)
تواريخ الأحداث: Date Created: 20191130 Date Completed: 20200407 Latest Revision: 20200408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6855077
DOI: 10.1155/2019/3649838
PMID: 31781613
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2019/3649838