دورية أكاديمية
أعرض في EDS

Prostaglandin D 2 signaling is not involved in the recovery of rat hind limb tendons from injury.

التفاصيل البيبلوغرافية
العنوان: Prostaglandin D 2 signaling is not involved in the recovery of rat hind limb tendons from injury.
المؤلفون: Sarver DC; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA., Sugg KB; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA., Talarek JR; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Hospital for Special Surgery, New York, NY, USA., Swanson JB; Hospital for Special Surgery, New York, NY, USA., Oliver DJ; Hospital for Special Surgery, New York, NY, USA., Hinken AC; Muscle Metabolism DPU, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA., Kramer HF; Muscle Metabolism DPU, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA., Mendias CL; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Hospital for Special Surgery, New York, NY, USA.; Department of Physiology & Biophysics, Weill Cornell Medical College, New York, NY, USA.
المصدر: Physiological reports [Physiol Rep] 2019 Nov; Vol. 7 (22), pp. e14289.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-
مواضيع طبية MeSH: Achilles Tendon/*injuries , Achilles Tendon/*metabolism , Prostaglandin D2/*metabolism , Recovery of Function/*physiology , Signal Transduction/*physiology, Achilles Tendon/drug effects ; Animals ; Biomechanical Phenomena/drug effects ; Biomechanical Phenomena/physiology ; Enzyme Inhibitors/pharmacology ; Hindlimb/drug effects ; Hindlimb/injuries ; Hindlimb/metabolism ; Male ; Prostaglandin D2/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/drug effects ; Signal Transduction/drug effects ; Tendon Injuries/metabolism
مستخلص: Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and improve functional recovery of tendons. Prostaglandin D 2 (PGD 2 ) plays an important role in promoting inflammation in some injury responses and chronic disease processes, and the inhibition of PGD 2 has improved healing and reduced disease burden in animal models and early clinical trials. Based on these findings, we sought to determine the role of PGD 2 signaling in the healing of injured tendon tissue. We tested the hypothesis that a potent and specific inhibitor of hematopoietic PGD synthase (HPGDS), GSK2894631A, would improve the recovery of tendons of adult male rats following an acute tenotomy and repair. To test this hypothesis, we performed a full-thickness plantaris tendon tenotomy followed by immediate repair and treated rats twice daily with either 0, 2, or 6 mg/kg of GSK2894631A. Tendons were collected either 7 or 21 days after surgical repair, and mechanical properties of tendons were assessed along with RNA sequencing and histology. While there were some differences in gene expression across groups, the targeted inhibition of HPGDS did not impact the functional repair of tendons after injury, as HPGDS expression was surprisingly low in injured tendons. These results indicate that PGD 2 signaling does not appear to be important in modulating the repair of injured tendon tissue.
(© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.)
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معلومات مُعتمدة: F32 AR067086 United States AR NIAMS NIH HHS; F32-AR067086 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: GSK2894631A; HPGDS; RNA sequencing; tendon mechanics; tenotomy
المشرفين على المادة: 0 (Enzyme Inhibitors)
RXY07S6CZ2 (Prostaglandin D2)
تواريخ الأحداث: Date Created: 20191130 Date Completed: 20200817 Latest Revision: 20231020
رمز التحديث: 20231020
مُعرف محوري في PubMed: PMC6882956
DOI: 10.14814/phy2.14289
PMID: 31782241
قاعدة البيانات: MEDLINE
الوصف
تدمد:2051-817X
DOI:10.14814/phy2.14289