دورية أكاديمية
Prostaglandin D 2 signaling is not involved in the recovery of rat hind limb tendons from injury.
العنوان: | Prostaglandin D |
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المؤلفون: | Sarver DC; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA., Sugg KB; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA., Talarek JR; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Hospital for Special Surgery, New York, NY, USA., Swanson JB; Hospital for Special Surgery, New York, NY, USA., Oliver DJ; Hospital for Special Surgery, New York, NY, USA., Hinken AC; Muscle Metabolism DPU, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA., Kramer HF; Muscle Metabolism DPU, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA., Mendias CL; Department of Orthopaedic Surgery, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Department of Molecular & Integrative Physiology, Section of Plastic & Reconstructive Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.; Hospital for Special Surgery, New York, NY, USA.; Department of Physiology & Biophysics, Weill Cornell Medical College, New York, NY, USA. |
المصدر: | Physiological reports [Physiol Rep] 2019 Nov; Vol. 7 (22), pp. e14289. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013- |
مواضيع طبية MeSH: | Achilles Tendon/*injuries , Achilles Tendon/*metabolism , Prostaglandin D2/*metabolism , Recovery of Function/*physiology , Signal Transduction/*physiology, Achilles Tendon/drug effects ; Animals ; Biomechanical Phenomena/drug effects ; Biomechanical Phenomena/physiology ; Enzyme Inhibitors/pharmacology ; Hindlimb/drug effects ; Hindlimb/injuries ; Hindlimb/metabolism ; Male ; Prostaglandin D2/antagonists & inhibitors ; Rats ; Rats, Sprague-Dawley ; Recovery of Function/drug effects ; Signal Transduction/drug effects ; Tendon Injuries/metabolism |
مستخلص: | Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and improve functional recovery of tendons. Prostaglandin D (© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.) |
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معلومات مُعتمدة: | F32 AR067086 United States AR NIAMS NIH HHS; F32-AR067086 United States AR NIAMS NIH HHS |
فهرسة مساهمة: | Keywords: GSK2894631A; HPGDS; RNA sequencing; tendon mechanics; tenotomy |
المشرفين على المادة: | 0 (Enzyme Inhibitors) RXY07S6CZ2 (Prostaglandin D2) |
تواريخ الأحداث: | Date Created: 20191130 Date Completed: 20200817 Latest Revision: 20231020 |
رمز التحديث: | 20231020 |
مُعرف محوري في PubMed: | PMC6882956 |
DOI: | 10.14814/phy2.14289 |
PMID: | 31782241 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2051-817X |
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DOI: | 10.14814/phy2.14289 |