دورية أكاديمية
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Influence of Obesity on Serum Concentrations of Acute-Phase Proteins in Horses.

التفاصيل البيبلوغرافية
العنوان: Influence of Obesity on Serum Concentrations of Acute-Phase Proteins in Horses.
المؤلفون: Girardi FM; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil., da Fonseca LA; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address: leandroabreu@ufv.br., Ribeiro Filho JD; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil., Souto PC; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil., Ferreira DAC; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil., Dornelas LRSM; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil., Bento LD; Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., de Carvalho Filho WP; Veterinary Departament, Universidade Federal de Viçosa, Viçosa, Minas Gerais, Brazil.
المصدر: Journal of equine veterinary science [J Equine Vet Sci] 2019 Dec; Vol. 83, pp. 102810. Date of Electronic Publication: 2019 Oct 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8216840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0737-0806 (Print) Linking ISSN: 07370806 NLM ISO Abbreviation: J Equine Vet Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : New York : Elsevier
Original Publication: [Wildomar, CA : William E. Jones, c1981-
مواضيع طبية MeSH: Acute-Phase Proteins/*metabolism , Horse Diseases/*blood , Obesity/*veterinary, Animals ; Brazil ; Electrophoresis, Polyacrylamide Gel/veterinary ; Horses ; Obesity/blood
مستخلص: Obesity in human and veterinary medicine is one of the most complex challenges within emerging diseases in the context of health. The problem of obesity in horses results in severe comorbidities; therefore, acute-phase proteins should be investigated for fluctuations increasing or decreasing by at least 25% in response to inflammation; these are candidates for future biomarkers and might provide new perspectives on early diagnosis and prognosis. Serum samples were analyzed in nine healthy animals (C) and nine obese animals (O). The proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and the concentrations determined by computerized densitometry; matrix assisted laser desorption ionization time of flight mass spectrometry/TOF mass spectrometry was performed to identify the proteins, and the results obtained were compared to the Equidae and Metazoa taxon protein database deposited in UNIPROT using the MASCOT application. Three proteins presented a difference between the groups; ceruloplasmin (Cp), α 1 -antitrypsin (α 1 -antitryp), and haptoglobin (Hp). The behavior of the Cp and Hp proteins was compatible with the available literature for obesity in other species. The α 1 -antitryp protein was positively correlated with leptin, demonstrating the need for further investigations. The initial study of these proteins was important due to the lack of information available on the influence of obesity on inflammatory biomarkers in horses in Brazil; therefore, we sought to verify a possible association between overweight and changes in the studied variables.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Acute-phase response; Biomarkers; Inflammation; obesity
المشرفين على المادة: 0 (Acute-Phase Proteins)
تواريخ الأحداث: Date Created: 20191204 Date Completed: 20200701 Latest Revision: 20220531
رمز التحديث: 20240628
DOI: 10.1016/j.jevs.2019.102810
PMID: 31791530
قاعدة البيانات: MEDLINE
الوصف
تدمد:0737-0806
DOI:10.1016/j.jevs.2019.102810