دورية أكاديمية
أعرض في EDS

K092A and K092B, Two Peptides Isolated from the Dogfish ( Scyliorhinus canicula L.), with Potential Antineoplastic Activity Against Human Prostate and Breast Cancer Cells.

التفاصيل البيبلوغرافية
العنوان: K092A and K092B, Two Peptides Isolated from the Dogfish ( Scyliorhinus canicula L.), with Potential Antineoplastic Activity Against Human Prostate and Breast Cancer Cells.
المؤلفون: Bosseboeuf A; Normandy University, University of Caen Normandy (UNICAEN), Sorbonne University, French National Museum of Natural History (MNHN), University of Antilles (UA), French National Centre for Scientific Research (CNRS), French National Institute for Sustainable Development (IRD), Biology of Aquatic Organisms and Ecosystems (BOREA) Research Unit, Sciences Department, CS14032, 14032 CAEN CEDEX 5, France., Baron A; Group CELLIS PHARMA, Parc Technopolitain Atalante Saint Malo, 35400 Saint Malo, France., Duval E; Group CELLIS PHARMA, Parc Technopolitain Atalante Saint Malo, 35400 Saint Malo, France., Gautier A; Normandy University, University of Caen Normandy (UNICAEN), Sorbonne University, French National Museum of Natural History (MNHN), University of Antilles (UA), French National Centre for Scientific Research (CNRS), French National Institute for Sustainable Development (IRD), Biology of Aquatic Organisms and Ecosystems (BOREA) Research Unit, Sciences Department, CS14032, 14032 CAEN CEDEX 5, France., Sourdaine P; Normandy University, University of Caen Normandy (UNICAEN), Sorbonne University, French National Museum of Natural History (MNHN), University of Antilles (UA), French National Centre for Scientific Research (CNRS), French National Institute for Sustainable Development (IRD), Biology of Aquatic Organisms and Ecosystems (BOREA) Research Unit, Sciences Department, CS14032, 14032 CAEN CEDEX 5, France., Auvray P; Group CELLIS PHARMA, Parc Technopolitain Atalante Saint Malo, 35400 Saint Malo, France.
المصدر: Marine drugs [Mar Drugs] 2019 Nov 28; Vol. 17 (12). Date of Electronic Publication: 2019 Nov 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Dogfish*, Antineoplastic Agents/*pharmacology , Breast Neoplasms/*drug therapy , Peptides/*pharmacology , Prostatic Neoplasms/*drug therapy, Action Potentials/drug effects ; Animals ; Autophagy/drug effects ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Male ; Mitochondria/drug effects ; Mitochondria/metabolism ; Prostatic Neoplasms/metabolism
مستخلص: Cancer therapy is currently a major challenge within the research community, especially in reducing the side effects of treatments and to develop new specific strategies against cancers that still have a poor prognosis. In this context, alternative strategies using biotechnologies, such as marine peptides, have been developed based on their promise of effectivity associated with a low toxicity for healthy cells. The purpose of the present paper is to investigate the active mechanism of two peptides that were isolated from the epigonal tissue of the lesser spotted dogfish Scyliorhinus canicula L., identified NFDTDEQALEDVFSKYG (K092A) and EAPPEAAEEDEW (K092B) on the in vitro growth inhibition of ZR-75-1 mammary carcinoma cells and MDA-Pca-2b prostate cancer cells. The effects of the peptides on cell proliferation and cell death mechanisms were studied by the flow cytometry and immunofluorescence microscopy approaches. The results have shown the onset of both K092A- and K092B-induced early cytoskeleton changes, and then cell cycle perturbations followed by non-apoptotic cell death. Moreover, impedance perturbation and plasma membrane perforation in ZR-75-1 K092A-treated cell cultures and autophagy inhibition in MDA-Pca-2b K092B-treated cells have been observed. In conclusion, these two bioactive peptides from dogfish exhibit antineoplastic activity on the human prostate and breast cancer cells in vitro.
References: Carcinogenesis. 2004 Feb;25(2):219-27. (PMID: 14578157)
Genes Dev. 2011 Oct 1;25(19):1999-2010. (PMID: 21979913)
Nat Rev Mol Cell Biol. 2009 Dec;10(12):854-65. (PMID: 19935668)
Mar Drugs. 2017 Mar 09;15(3):null. (PMID: 28282929)
Clin Cancer Res. 2001 Dec;7(12):3912-9. (PMID: 11751482)
Food Chem. 2015 May 1;174:37-43. (PMID: 25529649)
Placenta. 2010 Apr;31(4):347-50. (PMID: 20207415)
Cancer Biol Ther. 2007 May;6(5):775-80. (PMID: 17426448)
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15978-83. (PMID: 21930925)
Mol Cell Biol. 2005 Feb;25(3):1025-40. (PMID: 15657430)
FEBS Lett. 1988 Dec 19;242(1):161-6. (PMID: 2462511)
Peptides. 2009 Dec;30(12):2365-73. (PMID: 19720101)
Br J Pharmacol. 2017 Jun;174(11):1378-1394. (PMID: 27572703)
Cancer Cell Int. 2018 Nov 13;18:181. (PMID: 30473630)
Mol Biol Cell. 1999 May;10(5):1477-94. (PMID: 10233157)
Mar Drugs. 2013 Aug 26;11(9):3224-57. (PMID: 24065163)
Mol Cancer Ther. 2009 Dec;8(12):3360-8. (PMID: 19996280)
Prog Mol Subcell Biol. 2017;55:1-34. (PMID: 28238034)
Cancer Lett. 2014 Aug 28;351(1):13-22. (PMID: 24836189)
BMC Complement Altern Med. 2012 Oct 12;12:185. (PMID: 23062075)
Drug Discov Today. 2010 Jan;15(1-2):40-56. (PMID: 19879957)
J Nanobiotechnology. 2013 Jan 23;11:1. (PMID: 23343139)
Mar Drugs. 2009 Jun 22;7(2):258-67. (PMID: 19597584)
Integr Comp Biol. 2006 Dec 1;46(6):1072-1081. (PMID: 19343108)
Ophthalmol Clin North Am. 2006 Sep;19(3):381-91, vi. (PMID: 16935213)
Biochim Biophys Acta Gen Subj. 2018 Jan;1862(1):81-196. (PMID: 28844981)
Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. (PMID: 19773780)
Food Chem Toxicol. 2012 Oct;50(10):3577-94. (PMID: 22847136)
J Bioenerg Biomembr. 2011 Jun;43(3):275-85. (PMID: 21643697)
Mar Drugs. 2011;9(10):1840-59. (PMID: 22072999)
Mar Drugs. 2019 Aug 23;17(9):null. (PMID: 31443597)
Mar Drugs. 2018 Mar 22;16(4):null. (PMID: 29565311)
Biochim Biophys Acta. 2014 Feb;1838(2):532-45. (PMID: 23899502)
Mar Drugs. 2012 Jan;10(1):35-50. (PMID: 22363219)
J Amino Acids. 2012;2012:967347. (PMID: 23316341)
PLoS One. 2013 Sep 09;8(9):e72882. (PMID: 24039814)
Sci Rep. 2018 Jul 11;8(1):10474. (PMID: 29992983)
PLoS One. 2012;7(10):e45381. (PMID: 23071517)
World J Biol Chem. 2011 Oct 26;2(10):232-8. (PMID: 22031846)
Mar Drugs. 2016 Aug 16;14(8):. (PMID: 27537897)
PLoS One. 2012;7(1):e30745. (PMID: 22292029)
Mar Drugs. 2015 Jun 29;13(7):4006-43. (PMID: 26132844)
Cell Death Dis. 2013 Mar 28;4:e561. (PMID: 23538442)
Cancer Lett. 2019 May 1;449:66-75. (PMID: 30771431)
Am J Cancer Res. 2011;1(3):362-372. (PMID: 21969237)
Sci Rep. 2015 Sep 22;5:14310. (PMID: 26391685)
Sci Rep. 2019 Feb 25;9(1):2723. (PMID: 30804365)
Protein Sci. 2016 Jun;25(6):1084-95. (PMID: 27010507)
J Clin Invest. 2007 Feb;117(2):326-36. (PMID: 17235397)
Curr Protein Pept Sci. 2018;19(8):759-770. (PMID: 29332577)
معلومات مُعتمدة: 925RD153 and 2890/33528 Conseil Régional de Basse-Normandie and Fonds Européen de Développement Régional
فهرسة مساهمة: Keywords: MDA-Pca-2b; ZR-75-1; antineoplastic; cancer; lesser spotted dogfish (Scyliorhinus canicula); marine peptide
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Peptides)
تواريخ الأحداث: Date Created: 20191205 Date Completed: 20200527 Latest Revision: 20200527
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6950282
DOI: 10.3390/md17120672
PMID: 31795172
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md17120672