دورية أكاديمية
Implementation of test-and-treat with doxycycline and temephos ground larviciding as alternative strategies for accelerating onchocerciasis elimination in an area of loiasis co-endemicity: the COUNTDOWN consortium multi-disciplinary study protocol.
| العنوان: | Implementation of test-and-treat with doxycycline and temephos ground larviciding as alternative strategies for accelerating onchocerciasis elimination in an area of loiasis co-endemicity: the COUNTDOWN consortium multi-disciplinary study protocol. |
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| المؤلفون: | Wanji S; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon. samwandji@gmail.com.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon. samwandji@gmail.com., Nji TM; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon.; COUNTDOWN, Department of Sociology and Anthropology, Faculty of Social and Management Sciences, University of Buea, P.O. Box 63, Buea, Cameroon., Hamill L; Sightsavers, 35 Perrymount Road, Haywards Heath, UK., Dean L; COUNTDOWN, Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Ozano K; COUNTDOWN, Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Njouendou AJ; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon.; COUNTDOWN, Department of Biomedical Sciences, Faculty of Health Sciences, University of Buea, P.O. Box 12, Buea, Cameroon., Abong RA; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Obie ED; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Amuam A; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Ekanya R; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Ndongmo WPC; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Ndzeshang BL; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Fung EG; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon.; COUNTDOWN, Department of Sociology and Anthropology, Faculty of Social and Management Sciences, University of Buea, P.O. Box 63, Buea, Cameroon., Nnamdi DB; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon.; COUNTDOWN, Department of Sociology and Anthropology, Faculty of Social and Management Sciences, University of Buea, P.O. Box 63, Buea, Cameroon., Nkimbeng DA; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Teghen S; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Kah E; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Piotrowski H; COUNTDOWN, Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Forrer A; COUNTDOWN, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Khan JAM; COUNTDOWN, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Woode ME; Centre for Health Economics, Monash University, Victoria, Australia., Niessen L; COUNTDOWN, Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; Department of International Health, Johns Hopkins School of Public Health, Baltimore, USA., Watson V; COUNTDOWN, Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Njoumemi Z; Health Economics Unit, Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, P.O. Box 1364, Yaounde, Cameroon., Murdoch ME; COUNTDOWN, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.; West Herts Hospitals NHS Trust, Watford General Hospital, Vicarage Road, Watford, UK., Thomson R; COUNTDOWN, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Theobald S; COUNTDOWN, Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK., Enyong P; COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon.; COUNTDOWN, Research Foundation for Tropical Diseases and Environment, P.O. Box 474, Buea, Cameroon., Turner JD; COUNTDOWN, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK. Joseph.Turner@lstmed.ac.uk., Taylor MJ; COUNTDOWN, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK. |
| المصدر: | Parasites & vectors [Parasit Vectors] 2019 Dec 04; Vol. 12 (1), pp. 574. Date of Electronic Publication: 2019 Dec 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central |
| مواضيع طبية MeSH: | Insecticides* , Temefos*, Anthelmintics/*therapeutic use , Disease Eradication/*methods , Doxycycline/*therapeutic use , Onchocerciasis/*drug therapy , Simuliidae/*parasitology, Animals ; Cameroon ; Disease Eradication/organization & administration ; Feasibility Studies ; Health Plan Implementation ; Humans ; Ivermectin/therapeutic use ; Loiasis/epidemiology ; Onchocerca/drug effects ; Onchocerciasis/diagnosis ; Onchocerciasis/prevention & control ; Patient Acceptance of Health Care ; Prevalence ; Public Health/methods ; World Health Organization |
| مستخلص: | Background: Onchocerciasis is a priority neglected tropical disease targeted for elimination by 2025. The standard strategy to combat onchocerciasis is annual Community-Directed Treatment with ivermectin (CDTi). Yet, high prevalence rates and transmission persist following > 12 rounds in South-West Cameroon. Challenges include programme coverage, adherence to, and acceptability of ivermectin in an area of Loa loa co-endemicity. Loiasis patients harbouring heavy infections are at risk of potentially fatal serious adverse events following CDTi. Alternative strategies are therefore needed to achieve onchocerciasis elimination where CDTi effectiveness is suboptimal. Methods/design: We designed an implementation study to evaluate integrating World Health Organisation-endorsed alternative strategies for the elimination of onchocerciasis, namely test-and-treat with the macrofilaricide, doxycycline (TTd), and ground larviciding for suppression of blackfly vectors with the organophosphate temephos. A community-based controlled before-after intervention study will be conducted among > 2000 participants in 20 intervention (Meme River Basin) and 10 control (Indian River Basin) communities. The primary outcome measure is O. volvulus prevalence at follow-up 18-months post-treatment. The study involves four inter-disciplinary components: parasitology, entomology, applied social sciences and health economics. Onchocerciasis skin infection will be diagnosed by skin biopsy and Loa loa infection will be diagnosed by parasitological examination of finger-prick blood samples. A simultaneous clinical skin disease assessment will be made. Eligible skin-snip-positive individuals will be offered directly-observed treatment for 5 weeks with 100 mg/day doxycycline. Transmission assessments of onchocerciasis in the communities will be collected post-human landing catch of the local biting blackfly vector prior to ground larviciding with temephos every week (0.3 l/m 3 ) until biting rate falls below 5/person/day. Qualitative research, including in-depth interviews and focus-group discussions will be used to assess acceptability and feasibility of the implemented alternative strategies among intervention recipients and providers. Health economics will assess the cost-effectiveness of the implemented interventions. Conclusions: Using a multidisciplinary approach, we aim to assess the effectiveness of TTd, alone or in combination with ground larviciding, following a single intervention round and scrutinise the acceptability and feasibility of implementing at scale in similar hotspots of onchocerciasis infection, to accelerate onchocerciasis elimination. |
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| فهرسة مساهمة: | Keywords: Abate; Cameroon; Doxycycline; Multi-disciplinary; NTD Elimination; Onchocerciasis; Onchodermatitis; Temephos; Vector Control; Wolbachia |
| المشرفين على المادة: | 0 (Anthelmintics) 0 (Insecticides) 70288-86-7 (Ivermectin) N12000U13O (Doxycycline) ONP3ME32DL (Temefos) |
| تواريخ الأحداث: | Date Created: 20191206 Date Completed: 20200428 Latest Revision: 20200428 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6894124 |
| DOI: | 10.1186/s13071-019-3826-8 |
| PMID: | 31801631 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1756-3305 |
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| DOI: | 10.1186/s13071-019-3826-8 |