دورية أكاديمية
The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway.
| العنوان: | The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway. |
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| المؤلفون: | Wu T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., He K; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China.; Blood Transfusion Department, Zhongda Hospital, Southeast University, Nanjing, People's Republic of China., Liang X; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., Wei T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., Wang Y; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., Zou L; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., Zhang T; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., Xue Y; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China., Tang M; Key Laboratory of Environmental Medicine and Engineering, Ministry of Education; School of Public Health, Southeast University, Nanjing, People's Republic of China. |
| المصدر: | Journal of applied toxicology : JAT [J Appl Toxicol] 2020 Mar; Vol. 40 (3), pp. 388-402. Date of Electronic Publication: 2019 Dec 04. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley And Sons Country of Publication: England NLM ID: 8109495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1263 (Electronic) Linking ISSN: 0260437X NLM ISO Abbreviation: J Appl Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: [Philadelphia, Pa. : Heyden & Son, c1981- |
| مواضيع طبية MeSH: | Cadmium Compounds/*toxicity , Glycolysis/*drug effects , Hippocampus/*drug effects , Microglia/*drug effects , Quantum Dots/*toxicity , Sulfides/*toxicity , TOR Serine-Threonine Kinases/*metabolism , Tellurium/*toxicity , Zinc Compounds/*toxicity, Animals ; Cell Line ; Hippocampus/enzymology ; Hippocampus/ultrastructure ; Male ; Mice, Inbred ICR ; Microglia/enzymology ; Microglia/ultrastructure ; Oxidative Stress/drug effects ; Phenotype ; Signal Transduction |
| مستخلص: | The excellent optical property and relatively low toxicity of CdTe/ZnS core/shell quantum dots (QDs) make them an advanced fluorescent probe in the application of biomedicines, particularly in neuroscience. Thus, it is important to evaluate the biosafety of CdTe/ZnS QDs on the central nervous system (CNS). Our previous studies have suggested that the high possibility of CdTe/ZnS QDs being transported into the brain across the blood-brain barrier resulted in microglial activation and a shift of glycometabolism, but their underlying mechanism remains unclear. In this study, when mice were injected intravenously with CdTe/ZnS QDs through tail veins, the microglial activation, polarized into both M1 phenotype and M2 phenotype, and the neuronal impairment were observed in the hippocampus. Meanwhile, the increased pro- and anti-inflammatory cytokines released from BV2 microglial cells treated with CdTe/ZnS QDs also indicated that QD exposure was capable of inducing microglial activation in vitro. We further demonstrated that the glycolytic shift from oxidative phosphorylation switching into aerobic glycolysis was required in the microglial activation into M1 phenotype induced by CdTe/ZnS QD treatment, which was mediated through the mTOR signaling pathway. The findings, taken together, provide a mechanistic insight regarding the CdTe/ZnS QDs inducing microglial activation and the role of the glycolytic shift in it. (© 2019 John Wiley & Sons, Ltd.) |
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| فهرسة مساهمة: | Keywords: BV2 cells; aerobic glycolysis; inflammatory cytokine; mTOR; microglial activation; quantum dot |
| المشرفين على المادة: | 0 (Cadmium Compounds) 0 (Sulfides) 0 (Zinc Compounds) EC 2.7.1.1 (mTOR protein, mouse) EC 2.7.11.1 (TOR Serine-Threonine Kinases) KPS085631O (zinc sulfide) NQA0O090ZJ (Tellurium) STG188WO13 (cadmium telluride) |
| تواريخ الأحداث: | Date Created: 20191206 Date Completed: 20210712 Latest Revision: 20211204 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/jat.3912 |
| PMID: | 31802521 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-1263 |
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| DOI: | 10.1002/jat.3912 |