دورية أكاديمية
Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study.
| العنوان: | Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study. |
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| المؤلفون: | O'Brien JT; Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK., Firbank MJ; Institute of Neuroscience and Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK michael.firbank@ncl.ac.uk., Ritchie K; Centre for Dementia Prevention, University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UK.; INSERM, University of Montpellier, Montpellier, France., Wells K; The Centre for Psychiatry, Imperial College London, London, UK., Williams GB; Wolfson Brain Imaging Center, University of Cambridge, Cambridge, Cambridgeshire, UK., Ritchie CW; Centre for Dementia Prevention, University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UK., Su L; Department of Psychiatry, University of Cambridge, Cambridge, Cambridgeshire, UK. |
| المصدر: | Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2020 Feb; Vol. 91 (2), pp. 158-161. Date of Electronic Publication: 2019 Dec 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-330X (Electronic) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BMJ Publishing Group Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Atrophy/*pathology , Brain/*pathology , Cerebral Ventricles/*pathology , Dementia/*pathology, Adult ; Age Factors ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Neuropsychological Tests ; Predictive Value of Tests ; Risk Factors |
| مستخلص: | Background: Increased rates of brain atrophy on serial MRI are frequently used as a surrogate marker of disease progression in Alzheimer's disease and other dementias. However, the extent to which they are associated with future risk of dementia in asymptomatic subjects is not clear. In this study, we investigated the relationship between the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) risk score and longitudinal atrophy in middle-aged subjects. Materials and Methods: A sample of 167 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 735 days; SD 44 days). We measured longitudinal rates of brain atrophy using the FSL Siena toolbox. Results: Annual percentage rates of brain volume and ventricular volume change were greater in those with a high (>6) vs low CAIDE score-absolute brain volume percentage loss 0.17% (CI 0.07 to 0.27) and absolute ventricular enlargement 1.78% (CI 1.14 to 2.92) higher in the at risk group. Atrophy rates did not differ between subjects with and without a parental history of dementia, but were significantly correlated with age. Using linear regression, with covariates of age, sex and education, CAIDE score >6 was the only significant predictor of whole brain atrophy rates (p=0.025) while age (p=0.009), sex (p=0.002) and CAIDE>6 (p=0.017) all predicted ventricular expansion rate. Conclusion: Our results show that progressive brain atrophy is associated with increased risk of future dementia in asymptomatic middle-aged subjects, two decades before dementia onset. Competing Interests: Competing interests: JTO’B has no conflicts related to this study. Unrelated to this work, he has received honoraria for work as DSMB chair or member for TauRx, Axon, Eisai, has acted as a consultant for Lilly and has received honorarium for talks from GE Healthcare and research support from Alliance Medical. (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.) |
| التعليقات: | Comment in: Nat Rev Neurol. 2020 Mar;16(3):135-136. doi: 10.1038/s41582-020-0316-8. (PMID: 31988487) |
| معلومات مُعتمدة: | R380R/1114 United Kingdom DMT_ The Dunhill Medical Trust |
| تواريخ الأحداث: | Date Created: 20191207 Date Completed: 20200706 Latest Revision: 20240626 |
| رمز التحديث: | 20240626 |
| DOI: | 10.1136/jnnp-2019-321652 |
| PMID: | 31806724 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-330X |
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| DOI: | 10.1136/jnnp-2019-321652 |