دورية أكاديمية
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study.
| العنوان: | Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study. |
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| المؤلفون: | Husebye ESN; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Gilhus NE; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Spigset O; Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Daltveit AK; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.; Department of Health Registries, Norwegian Institute of Public Health, Bergen, Norway., Bjørk MH; Department of Clinical Medicine, University of Bergen, Bergen, Norway.; Department of Neurology, Haukeland University Hospital, Bergen, Norway. |
| المصدر: | European journal of neurology [Eur J Neurol] 2020 Apr; Vol. 27 (4), pp. 667-675. Date of Electronic Publication: 2019 Dec 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 9506311 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-1331 (Electronic) Linking ISSN: 13515101 NLM ISO Abbreviation: Eur J Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2014- > : Oxford : Wiley Original Publication: Oxford ; New York : Rapid Communications, [1994- |
| مواضيع طبية MeSH: | Prenatal Exposure Delayed Effects*, Anticonvulsants/*adverse effects , Epilepsy/*drug therapy , Language Development Disorders/*chemically induced, Anticonvulsants/therapeutic use ; Carbamazepine/adverse effects ; Carbamazepine/therapeutic use ; Child ; Child, Preschool ; Cohort Studies ; Female ; Humans ; Male ; Mothers ; Norway ; Pregnancy ; Valproic Acid/adverse effects ; Valproic Acid/therapeutic use |
| مستخلص: | Background and Purpose: The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8 years of mothers with epilepsy. Methods: The study population included children of mothers with and without epilepsy enrolled in the Norwegian Mother and Child Cohort Study 1999-2008. Mothers prospectively provided information on epilepsy diagnosis, AED use during pregnancy and the child's language abilities at age 5 and 8 years, in questionnaires with validated language screening tools. AED concentrations in gestation week 17-19 and in the umbilical cord were measured. Results: The study population included 346 AED-exposed and 388 AED-unexposed children of mothers with epilepsy, and 113 674 children of mothers without epilepsy. Mothers of 117 and 121 AED-exposed children responded to the questionnaires at age 5 and 8 years, respectively. For AED-exposed children, the adjusted odds ratio for language impairment was 1.6 [confidence interval (CI) 1.1-2.5, P = 0.03] at age 5 years and 2.0 (CI 1.4-3.0, P < 0.001) at age 8 years, compared to children of mothers without epilepsy. Children exposed to carbamazepine monotherapy had a significantly increased risk of language impairment compared to control children at age 8 years (adjusted odds ratio 3.8, CI 1.6-9.0, P = 0.002). Higher maternal valproate concentrations correlated with language impairment at age 5 years. Periconceptional folic acid supplement use protected against AED-associated language impairment. Conclusion: Foetal AED exposure in utero is associated with an increased risk of language impairment in children aged 5 and 8 years of mothers with epilepsy. Periconceptional folic acid use had a protective effect on AED-associated language impairment. (© 2019 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.) |
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| معلومات مُعتمدة: | International Norwegian Chapter International League Against Epilepsy; International The fund of Dr. Nils Henrichsen and Anna Henrichsen; International Norwegian Epilepsy Foundation; International The General Medical Research Fund; International The fund of Lawyer Rolf Sandberg Reberg and Ellen Marie Reberg |
| فهرسة مساهمة: | Keywords: MoBa; anticonvulsants; antiepileptic drugs; epilepsy; language impairment; seizures |
| المشرفين على المادة: | 0 (Anticonvulsants) 33CM23913M (Carbamazepine) 614OI1Z5WI (Valproic Acid) |
| تواريخ الأحداث: | Date Created: 20191210 Date Completed: 20210302 Latest Revision: 20210302 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/ene.14140 |
| PMID: | 31814202 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-1331 |
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| DOI: | 10.1111/ene.14140 |