دورية أكاديمية
Immunosuppressants in Organ Transplantation.
| العنوان: | Immunosuppressants in Organ Transplantation. |
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| المؤلفون: | Tönshoff B; Department of Pediatrics I, University Children's Hospital, Heidelberg, Germany. Burkhard.Toenshoff@med.uni-heidelberg.de. |
| المصدر: | Handbook of experimental pharmacology [Handb Exp Pharmacol] 2020; Vol. 261, pp. 441-469. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902231 Publication Model: Print Cited Medium: Print ISSN: 0171-2004 (Print) Linking ISSN: 01712004 NLM ISO Abbreviation: Handb Exp Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Graft Rejection* , Immunosuppressive Agents*, Adult ; Child ; Cyclosporine/chemistry ; Drug Therapy, Combination ; Humans ; Mycophenolic Acid/chemistry ; Mycophenolic Acid/pharmacology ; Mycophenolic Acid/therapeutic use ; Tacrolimus/therapeutic use |
| مستخلص: | The goal of immunosuppressive therapy post-transplantation in pediatric renal transplant recipients is to prevent acute and chronic rejection while minimizing drug side effects. Most therapies alter immune response mechanisms but are not immunologically specific, and a careful balance is required to find the dose that prevents rejection of the graft while minimizing the risks of overimmunosuppression leading to infection and cancer. While this chapter because of space constraints focuses on immunosuppressive therapy in pediatric renal transplant recipients, many aspects can be applied on pediatric recipients of other solid organ transplants such as the liver and heart. The major maintenance immunosuppressive agents currently used in various combination regimens are tacrolimus, cyclosporine, mycophenolate mofetil, azathioprine, everolimus, sirolimus, and glucocorticoids (steroids). Although data from adult renal transplantation trials are used to help guide management decisions in pediatric patients, immunosuppressive therapy in pediatric renal transplant recipients often must be modified because of the unique dosage requirements and clinical effects of these agents in children, including their impact on growth and development. The optimal immunosuppressive therapy post-transplant is not established. The goal remains to find the best combination of immunosuppressive agents that optimizes allograft survival by preventing acute rejection while limiting drug toxicities. |
| فهرسة مساهمة: | Keywords: Calcineurin inhibitors; Cyclosporine; Everolimus; Glucocorticoids (steroids); Immunosuppressive induction therapy; Immunosuppressive maintenance therapy; Mycophenolate mofetil; Pediatric renal transplantation; Tacrolimus |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) 83HN0GTJ6D (Cyclosporine) HU9DX48N0T (Mycophenolic Acid) WM0HAQ4WNM (Tacrolimus) |
| تواريخ الأحداث: | Date Created: 20191211 Date Completed: 20201029 Latest Revision: 20201029 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/164_2019_331 |
| PMID: | 31820175 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0171-2004 |
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| DOI: | 10.1007/164_2019_331 |