دورية أكاديمية
Delta- and mu-opioid pathways are involved in the analgesic effect of Ocimum basilicum L in mice.
| العنوان: | Delta- and mu-opioid pathways are involved in the analgesic effect of Ocimum basilicum L in mice. |
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| المؤلفون: | Bae AH; Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon, Republic of Korea., Kim G; Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon, Republic of Korea., Seol GH; Department of Basic Nursing Science, Korea University School of Nursing, Seoul, 136-713, South Korea., Lee SB; KT&G Research Institute, Daejeon, 34337, South Korea., Lee JM; KT&G Research Institute, Daejeon, 34337, South Korea., Chang W; Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon, Republic of Korea., Min SS; Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon, Republic of Korea. Electronic address: ssmin@eulji.ac.kr. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2020 Mar 25; Vol. 250, pp. 112471. Date of Electronic Publication: 2019 Dec 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Analgesics/*pharmacology , Ocimum basilicum/*chemistry , Oils, Volatile/*pharmacology , Pain/*drug therapy, Analgesics/administration & dosage ; Analgesics/isolation & purification ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Inflammation/drug therapy ; Inflammation/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Oils, Volatile/administration & dosage ; Oils, Volatile/isolation & purification ; Pain/physiopathology ; Receptors, Opioid, delta/drug effects ; Receptors, Opioid, delta/metabolism ; Receptors, Opioid, mu/drug effects ; Receptors, Opioid, mu/metabolism |
| مستخلص: | Ethnopharmacological Relevance: Ocimum basilicum L. is a perennial herb that has been used in traditional Asian Indian medicine for thousands of years as a natural anti-inflammatory, antibiotic, diuretic, and analgesic. Aim of the Study: The present study was conducted to investigate the analgesic effects of basil essential oil (BEO) in inflammatory pain models and identify underlying mechanisms. We further investigated whether BEO affects physiological pain and motor coordination. Materials and Methods: The analgesic effects of BEO were assessed in various mouse experimental pain models using formalin, acetic acid, heat, and carrageenan as stimuli. BEO was administered by intraperitoneal injection or inhalation. The involvement of various pathways in the analgesic effect of BEO was assessed by pretreating mice with selective pharmacological inhibitors, administered intraperitoneally. Opioid pathways were tested using the κ-opioid antagonist 5'-guanidinonaltrindole (GNTI; 0.3 mg/kg), δ-opioid antagonist naltrindole (NTD; 5 mg/kg) and μ-opioid antagonist naloxone (NAL; 8 mg/kg); nitric oxide (NO) pathways were tested using the NO synthase inhibitor N-nitro l-arginine methyl ester (L-NAME; 37.5 mg/kg) and NO precursor L-arginine (L-Arg; 600 mg/kg); and K Results: BEO exerted analgesic effects in all pain models. Notably, pretreatment with naltrindole, naloxone, or L-arginine significantly reduced the analgesic effects of BEO in the formalin test. BEO increased mean withdrawal latencies in a thermal plantar test at a high dose, but not at lower doses. BEO had no effect on motor coordination. Conclusions: Our findings indicate that the analgesic effects of BEO are primarily mediated by delta- and mu-opioid pathways and further suggest that BEO has potential for development as an analgesic agent for the relief of inflammatory pain. (Copyright © 2019. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Acetic-acid test; Formalin test; Ocimum basilicum L.; Opioid pathway; Pain |
| المشرفين على المادة: | 0 (Analgesics) 0 (Oils, Volatile) 0 (Receptors, Opioid, delta) 0 (Receptors, Opioid, mu) |
| تواريخ الأحداث: | Date Created: 20191215 Date Completed: 20201104 Latest Revision: 20201104 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jep.2019.112471 |
| PMID: | 31837414 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2019.112471 |