دورية أكاديمية
Ibuprofen and diclofenac impair the cardiovascular development of zebrafish (Danio rerio) at low concentrations.
| العنوان: | Ibuprofen and diclofenac impair the cardiovascular development of zebrafish (Danio rerio) at low concentrations. |
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| المؤلفون: | Zhang K; School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China., Yuan G; Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China., Werdich AA; Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA, 02115, USA., Zhao Y; School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai, 200092, China. Electronic address: zhaoyanbin@sjtu.edu.cn. |
| المصدر: | Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2020 Mar; Vol. 258, pp. 113613. Date of Electronic Publication: 2019 Nov 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents, Non-Steroidal/*administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/*toxicity , Diclofenac/*administration & dosage , Diclofenac/*toxicity , Ibuprofen/*administration & dosage , Ibuprofen/*toxicity , Organogenesis/*drug effects , Water Pollutants, Chemical/*adverse effects , Zebrafish/*embryology , Zebrafish/*growth & development, Animals ; Embryo, Nonmammalian/drug effects |
| مستخلص: | The non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen and diclofenac are highly prescribed worldwide and their presence in aquatic system may pose a potential risk to aquatic organisms. Here, we systematically assessed their cardiovascular disruptive effects in zebrafish (Danio rerio) at environmentally relevant concentrations between 0.04 and 25.0 μg/L. Ibuprofen significantly increased the cardiac outputs of zebrafish embryos at actual concentrations of 0.91, 4.3 and 21.9 μg/L. It up-regulated the blood cell velocity, total blood flow and down-regulated the blood cell density at concentrations of 4.3 μg/L and higher. In comparison, diclofenac led to inhibition of spontaneous muscle contractions and decreased hatching rate of zebrafish embryos at the highest concentration (24.1 μg/L), while it had negligible effects on the cardiac physiology and hemodynamics. Transcriptional analysis of biomarker genes involved in cardiovascular physiology, such as the significantly up-regulated nppa and nkx2.5 expressions response to ibuprofen but not to diclofenac, is consistent with these observations. In addition, both ibuprofen and diclofenac altered the morphology of intersegmental vessels at high concentrations. Our results revealed unexpected cardiovascular functional alterations of NSAIDs to fish at environmental or slightly higher than surface water concentrations and thus provided novel insights into the understanding of their potential environmental risks. Competing Interests: Declaration of competing interest The authors declare no competing financial interest. (Copyright © 2019. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Cardiac physiology; Diclofenac; Hemodynamics; Ibuprofen; Zebrafish |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents, Non-Steroidal) 0 (Water Pollutants, Chemical) 144O8QL0L1 (Diclofenac) WK2XYI10QM (Ibuprofen) |
| تواريخ الأحداث: | Date Created: 20191216 Date Completed: 20200330 Latest Revision: 20200330 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.envpol.2019.113613 |
| PMID: | 31838392 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-6424 |
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| DOI: | 10.1016/j.envpol.2019.113613 |